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HUMAN:K1C17

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) KRT17
Protein Name(s) Keratin, type I cytoskeletal 17

39.1 Cytokeratin-17 CK-17 Keratin-17 K17

External Links
UniProt Q04695
EMBL Z19574
X62571
AK095342
AC022596
AL353997
BC000159
BC011901
BC056421
BC072018
BC072019
S78515
EF608068
EF608069
EF608070
EF608071
CCDS CCDS11402.1
PIR S30433
RefSeq NP_000413.1
UniGene Hs.2785
ProteinModelPortal Q04695
SMR Q04695
BioGrid 110070
DIP DIP-33093N
IntAct Q04695
MINT MINT-256746
PhosphoSite Q04695
DMDM 547751
SWISS-2DPAGE Q04695
MaxQB Q04695
PaxDb Q04695
PRIDE Q04695
DNASU 3872
Ensembl ENST00000311208
GeneID 3872
KEGG hsa:3872
UCSC uc002hxh.2
CTD 3872
GeneCards GC17M039775
GeneReviews KRT17
H-InvDB HIX0059686
HGNC HGNC:6427
HPA CAB000029
HPA000452
HPA000453
MIM 148069
167210
184500
neXtProt NX_Q04695
Orphanet 2309
841
PharmGKB PA30214
eggNOG NOG148784
GeneTree ENSGT00760000118808
HOVERGEN HBG013015
InParanoid Q04695
KO K07604
OMA GCYSFGS
OrthoDB EOG7FV3Q8
PhylomeDB Q04695
TreeFam TF332742
GeneWiki Keratin_17
GenomeRNAi 3872
NextBio 15209
PMAP-CutDB Q04695
PRO PR:Q04695
Proteomes UP000005640
Bgee Q04695
ExpressionAtlas Q04695
Genevestigator Q04695
GO GO:0071944
GO:0005737
GO:0070062
GO:0005882
GO:0042289
GO:0032395
GO:0005200
GO:0008544
GO:0045109
GO:0031424
GO:0002009
GO:0030307
GO:0051798
GO:0045727
GO:0007165
InterPro IPR001664
IPR018039
IPR002957
IPR009053
PANTHER PTHR23239
Pfam PF00038
PRINTS PR01248
SUPFAM SSF46579
PROSITE PS00226

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0031069

hair follicle morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QWL7

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19199708[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

enables

GO:0042289

MHC class II protein binding

PMID:15795121[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P13760

F

Seeded From UniProt

complete

enables

GO:0042289

MHC class II protein binding

PMID:15795121[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P13761

F

Seeded From UniProt

complete

enables

GO:0032395

MHC class II receptor activity

PMID:15795121[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:15795121[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0045111

intermediate filament cytoskeleton

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0071944

cell periphery

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QWL7
ensembl:ENSMUSP00000079699

C

Seeded From UniProt

complete

involved_in

GO:0051798

positive regulation of hair follicle development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QWL7
ensembl:ENSMUSP00000079699

P

Seeded From UniProt

complete

involved_in

GO:0045727

positive regulation of translation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QWL7
ensembl:ENSMUSP00000079699

P

Seeded From UniProt

complete

involved_in

GO:0045109

intermediate filament organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QWL7
ensembl:ENSMUSP00000079699

P

Seeded From UniProt

complete

involved_in

GO:0031424

keratinization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QWL7
ensembl:ENSMUSP00000079699

P

Seeded From UniProt

complete

involved_in

GO:0031069

hair follicle morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QWL7
ensembl:ENSMUSP00000079699

P

Seeded From UniProt

complete

involved_in

GO:0030307

positive regulation of cell growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QWL7
ensembl:ENSMUSP00000079699

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QWL7
ensembl:ENSMUSP00000079699

C

Seeded From UniProt

complete

involved_in

GO:0002009

morphogenesis of an epithelium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QWL7
ensembl:ENSMUSP00000079699

P

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001664
InterPro:IPR002957

F

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001664

C

Seeded From UniProt

complete

involved_in

GO:0008544

epidermis development

PMID:7539673[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

PMID:1281771[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005200

structural constituent of cytoskeleton

PMID:1281771[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0070268

cornification

Reactome:R-HSA-6809371

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031424

keratinization

Reactome:R-HSA-6805567

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8942224
Reactome:R-HSA-6814764
Reactome:R-HSA-6814734
Reactome:R-HSA-6814387
Reactome:R-HSA-6814298
Reactome:R-HSA-6811539
Reactome:R-HSA-6810937
Reactome:R-HSA-6810357
Reactome:R-HSA-6809663
Reactome:R-HSA-6809393
Reactome:R-HSA-6806629
Reactome:R-HSA-6806613
Reactome:R-HSA-6806610
Reactome:R-HSA-6805573
Reactome:R-HSA-6805546

ECO:0000304

author statement supported by traceable reference used in manual assertion















C

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0416
UniProtKB-KW:KW-0403

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Shen, Z et al. (2005) HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis. J. Dermatol. Sci. 38 25-39 PubMed GONUTS page
  3. McLean, WH et al. (1995) Keratin 16 and keratin 17 mutations cause pachyonychia congenita. Nat. Genet. 9 273-8 PubMed GONUTS page
  4. 4.0 4.1 Troyanovsky, SM et al. (1992) Characterization of the human gene encoding cytokeratin 17 and its expression pattern. Eur. J. Cell Biol. 59 127-37 PubMed GONUTS page