HUMAN:INF2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	INF2 (synonyms: C14orf151, C14orf173)
Protein Name(s)	Inverted formin-2 HBEBP2-binding protein C
External Links
UniProt	Q27J81
EMBL	AK025709 AK290083 AL583722 CH471061 BC006173 BC008756 BC064828 BX248757 DQ395338 DQ395339 DQ395340 AL832905
CCDS	CCDS41999.1 CCDS45173.1 CCDS9989.2
RefSeq	NP_001026884.3 NP_071934.3 NP_116103.1
UniGene	Hs.24956
ProteinModelPortal	Q27J81
SMR	Q27J81
BioGrid	122172
IntAct	Q27J81
MINT	MINT-7034523
STRING	9606.ENSP00000376410
iPTMnet	Q27J81
PhosphoSite	Q27J81
SwissPalm	Q27J81
BioMuta	INF2
DMDM	166215588
EPD	Q27J81
MaxQB	Q27J81
PaxDb	Q27J81
PRIDE	Q27J81
DNASU	64423
Ensembl	ENST00000330634 ENST00000392634 ENST00000398337
GeneID	64423
KEGG	hsa:64423
UCSC	uc001yoy.5
CTD	64423
GeneCards	INF2
HGNC	HGNC:23791
HPA	HPA000724
MalaCards	INF2
MIM	610982 613237 614455
neXtProt	NX_Q27J81
Orphanet	93114 93213
PharmGKB	PA162392025
eggNOG	KOG1922 ENOG410XQR0
GeneTree	ENSGT00760000118986
HOVERGEN	HBG081794
InParanoid	Q27J81
OMA	QPVDHAQ
OrthoDB	EOG7T4MN4
PhylomeDB	Q27J81
TreeFam	TF326300
ChiTaRS	INF2
GeneWiki	INF2
GenomeRNAi	64423
PMAP-CutDB	Q27J81
PRO	PR:Q27J81
Proteomes	UP000005640
Bgee	Q27J81
CleanEx	HS_INF2
ExpressionAtlas	Q27J81
Genevisible	Q27J81
GO	GO:0048471 GO:0030036 GO:0090140
InterPro	IPR016024 IPR015425 IPR010472 IPR014768 IPR010473 IPR027649 IPR003124
PANTHER	PTHR23213:SF5
Pfam	PF06367 PF06371 PF02181 PF02205
SMART	SM01139 SM01140 SM00498
SUPFAM	SSF48371
PROSITE	PS51444 PS51232 PS51082

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0090141	positive regulation of mitochondrial fission	PMID:26305500	ECO:0000316		UniProtKB:D3Z495	P		Figure 6C: Cells overexpressing active INF2 and Spire1C show shortened mitochondria as compared to control, while cells overexpressing INF2 and Spire1C that lacks the KIND domain show elongated, tubular mitochondria. Figure 6D: Cells overexpressing Spire1C treated with INF2 siRNA show elongated mitochondria as compared to cells treated with scrambled siRNA.	complete CACAO 12179
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:20023659	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090140	regulation of mitochondrial fission		ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003124 InterPro:IPR010472 InterPro:IPR010473	F		Seeded From UniProt	complete
involved_in	GO:0016043	cellular component organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010472	P		Seeded From UniProt	complete
enables	GO:0017048	Rho GTPase binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010473	F		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010473 InterPro:IPR027649	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
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References

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