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HUMAN:IL22
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | IL22 (synonyms: ILTIF, ZCYTO18) | |
| Protein Name(s) | Interleukin-22
IL-22 Cytokine Zcyto18 IL-10-related T-cell-derived-inducible factor IL-TIF | |
| External Links | ||
| UniProt | Q9GZX6 | |
| EMBL | AJ277247 AJ277248 AF279437 AY358890 AF387519 BC066263 BC067510 BC069112 BC069308 BC070261 | |
| CCDS | CCDS8982.1 | |
| RefSeq | NP_065386.1 | |
| UniGene | Hs.287369 | |
| PDB | 1M4R 1YKB 3DGC 3DLQ 3G9V 3Q1S | |
| PDBsum | 1M4R 1YKB 3DGC 3DLQ 3G9V 3Q1S | |
| ProteinModelPortal | Q9GZX6 | |
| SMR | Q9GZX6 | |
| BioGrid | 119096 | |
| DIP | DIP-46035N | |
| IntAct | Q9GZX6 | |
| MINT | MINT-6693924 | |
| STRING | 9606.ENSP00000329384 | |
| BioMuta | IL22 | |
| DMDM | 17366814 | |
| PaxDb | Q9GZX6 | |
| PRIDE | Q9GZX6 | |
| DNASU | 50616 | |
| Ensembl | ENST00000328087 ENST00000538666 | |
| GeneID | 50616 | |
| KEGG | hsa:50616 | |
| UCSC | uc001sty.2 | |
| CTD | 50616 | |
| GeneCards | IL22 | |
| HGNC | HGNC:14900 | |
| MIM | 605330 | |
| neXtProt | NX_Q9GZX6 | |
| PharmGKB | PA29822 | |
| eggNOG | ENOG410IV9D ENOG4112217 | |
| GeneTree | ENSGT00510000048550 | |
| HOGENOM | HOG000280686 | |
| HOVERGEN | HBG018572 | |
| InParanoid | Q9GZX6 | |
| KO | K05445 | |
| OMA | HIQKNVQ | |
| OrthoDB | EOG7J9VR1 | |
| PhylomeDB | Q9GZX6 | |
| TreeFam | TF333253 | |
| SignaLink | Q9GZX6 | |
| EvolutionaryTrace | Q9GZX6 | |
| GeneWiki | Interleukin_22 | |
| GenomeRNAi | 50616 | |
| NextBio | 53128 | |
| PRO | PR:Q9GZX6 | |
| Proteomes | UP000005640 | |
| Bgee | Q9GZX6 | |
| CleanEx | HS_IL22 | |
| Genevisible | Q9GZX6 | |
| GO | GO:0005576 GO:0005615 GO:0005125 GO:0045518 GO:0006953 GO:0007267 GO:0006955 GO:0006954 GO:0046427 GO:0051384 | |
| Gene3D | 1.20.1250.10 | |
| InterPro | IPR009079 IPR012351 IPR020443 IPR020423 IPR020453 | |
| PANTHER | PTHR11585 | |
| Pfam | PF14565 | |
| PIRSF | PIRSF037726 | |
| PRINTS | PR01936 | |
| SUPFAM | SSF47266 | |
| PROSITE | PS00520 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0045518 |
interleukin-22 receptor binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006953 |
acute-phase response |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051384 |
response to glucocorticoid |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:G3V6X6 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:G3V6X6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:R-HSA-8854691 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-8987236 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Xie, MH et al. (2000) Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J. Biol. Chem. 275 31335-9 PubMed GONUTS page
- ↑ Dumoutier, L et al. (2000) Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. Proc. Natl. Acad. Sci. U.S.A. 97 10144-9 PubMed GONUTS page
- ↑ Xu, W et al. (2001) A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Proc. Natl. Acad. Sci. U.S.A. 98 9511-6 PubMed GONUTS page
