HUMAN:IL13

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IL13 (synonyms: NC30)
Protein Name(s)	Interleukin-13 IL-13
External Links
UniProt	P35225
EMBL	X69079 X69079 L06801 U10307 U31120 AF377331 AC004039 BC096139 AF043334
CCDS	CCDS4157.1
PIR	I38060
RefSeq	NP_002179.2
UniGene	Hs.845
PDB	1GA3 1IJZ 1IK0 1J9U 3BPO 3G6D 3ITR 3ITS 3L5W 3L5X 3LB6 4I77 4PS4
PDBsum	1GA3 1IJZ 1IK0 1J9U 3BPO 3G6D 3ITR 3ITS 3L5W 3L5X 3LB6 4I77 4PS4
ProteinModelPortal	P35225
SMR	P35225
BioGrid	109810
DIP	DIP-3224N
IntAct	P35225
STRING	9606.ENSP00000304915
DMDM	239938644
PRIDE	P35225
DNASU	3596
Ensembl	ENST00000304506
GeneID	3596
KEGG	hsa:3596
CTD	3596
GeneCards	GC05P131991
H-InvDB	HIX0031957
HGNC	HGNC:5973
HPA	HPA042421
MIM	147683 607154
neXtProt	NX_P35225
PharmGKB	PA199
eggNOG	NOG42350
GeneTree	ENSGT00390000003225
HOGENOM	HOG000113028
HOVERGEN	HBG006140
InParanoid	P35225
KO	K05435
OrthoDB	EOG78SQMB
PhylomeDB	P35225
TreeFam	TF336383
SignaLink	P35225
ChiTaRS	IL13
EvolutionaryTrace	P35225
GeneWiki	Interleukin_13
GenomeRNAi	3596
NextBio	14053
PRO	PR:P35225
Proteomes	UP000005640
Bgee	P35225
CleanEx	HS_IL13
ExpressionAtlas	P35225
Genevestigator	P35225
GO	GO:0005737 GO:0009897 GO:0005576 GO:0005615 GO:0005125 GO:0007267 GO:0006928 GO:0071345 GO:0071260 GO:0006955 GO:0006954 GO:0001774 GO:1901247 GO:0033861 GO:1901215 GO:0071635 GO:0030890 GO:0032723 GO:0002639 GO:1901251 GO:0043032 GO:2000231 GO:0050714 GO:0051281 GO:0048661 GO:0042526 GO:0010155 GO:0045471 GO:0032496 GO:0035094 GO:0007165
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR020470 IPR001325 IPR018096
PANTHER	PTHR11322
Pfam	PF03487
PRINTS	PR01929
SMART	SM00190
SUPFAM	SSF47266
PROSITE	PS00838

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0044319		PMID:11698262^[1]	ECO:0000314					Based on Figure 7 and Figure 8 wound-healing of Calu-3 epithelial lung cells is reduced by Interleukin-13 (IL-13).	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:12574355^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P29965	P	regulates_expression_of:(ENSEMBL:ENSG00000111732) occurs_in:(CL:0000236) regulates_o_occurs_in:(CL:0000236)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42203	P	regulates_o_occurs_in:(CL:0000129) regulates_expression_of:(ENSEMBL:ENSG00000135218)\|regulates_o_occurs_in(CL:0000129) regulates_expression_of:(ENSEMBL:ENSG00000119912)	Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:24906148^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20109	P		Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	PMID:16034134^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903660	negative regulation of complement-dependent cytotoxicity	PMID:16034134^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901251	positive regulation of lung goblet cell differentiation	PMID:20539013^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901247	negative regulation of lung ciliated cell differentiation	PMID:20539013^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:20041150^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16275384^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20109	C		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20109 ensembl:ENSMUSP00000020650	P		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20109 ensembl:ENSMUSP00000020650	P		Seeded From UniProt	complete
involved_in	GO:0043306	positive regulation of mast cell degranulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20109 ensembl:ENSMUSP00000020650	P		Seeded From UniProt	complete
involved_in	GO:0043032	positive regulation of macrophage activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20109 ensembl:ENSMUSP00000020650	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20109 ensembl:ENSMUSP00000020650	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20109 ensembl:ENSMUSP00000020650	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20109 ensembl:ENSMUSP00000020650	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20109 ensembl:ENSMUSP00000020650	C		Seeded From UniProt	complete
involved_in	GO:0002639	positive regulation of immunoglobulin production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20109 ensembl:ENSMUSP00000020650	P		Seeded From UniProt	complete
involved_in	GO:2000231	positive regulation of pancreatic stellate cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0071635	negative regulation of transforming growth factor beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0050714	positive regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0043270	positive regulation of ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0033861	negative regulation of NAD(P)H oxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0032723	positive regulation of connective tissue growth factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0010155	regulation of proton transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	C		Seeded From UniProt	complete
enables	GO:0005144	interleukin-13 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	F		Seeded From UniProt	complete
involved_in	GO:0002639	positive regulation of immunoglobulin production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
involved_in	GO:0001774	microglial cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42203 ensembl:ENSRNOP00000010121	P		Seeded From UniProt	complete
enables	GO:0005126	cytokine receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001325 InterPro:IPR018096	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001325 InterPro:IPR018096	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001325 InterPro:IPR018096	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:8096327^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6788628 Reactome:R-HSA-6788582 Reactome:R-HSA-6788571 Reactome:R-HSA-6786118 Reactome:R-HSA-6786114 Reactome:R-HSA-6786110 Reactome:R-HSA-6786050 Reactome:R-HSA-449818	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ahdieh, M et al. (2001) Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-gamma. Am. J. Physiol., Cell Physiol. 281 C2029-38 PubMed GONUTS page
↑ Zhou, C et al. (2003) Human activation-induced cytidine deaminase is induced by IL-4 and negatively regulated by CD45: implication of CD45 as a Janus kinase phosphatase in antibody diversification. J. Immunol. 170 1887-93 PubMed GONUTS page
↑ Qiu, Y et al. (2014) Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157 1292-308 PubMed GONUTS page
↑ ^4.0 ^4.1 Grehan, JF et al. (2005) IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway. J. Immunol. 175 1903-10 PubMed GONUTS page
↑ ^5.0 ^5.1 Turner, J et al. (2011) Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium. Am. J. Respir. Cell Mol. Biol. 44 276-84 PubMed GONUTS page
↑ Feng, J et al. (2009) Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels. PLoS ONE 4 e8480 PubMed GONUTS page
↑ Lin, W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J. Allergy Clin. Immunol. 116 1106-15 PubMed GONUTS page
↑ Minty, A et al. (1993) Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature 362 248-50 PubMed GONUTS page

[PMID:11698262-1] Ahdieh, M et al. (2001) Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-gamma. Am. J. Physiol., Cell Physiol. 281 C2029-38 PubMed GONUTS page

[PMID:12574355-2] Zhou, C et al. (2003) Human activation-induced cytidine deaminase is induced by IL-4 and negatively regulated by CD45: implication of CD45 as a Janus kinase phosphatase in antibody diversification. J. Immunol. 170 1887-93 PubMed GONUTS page

[PMID:24906148-3] Qiu, Y et al. (2014) Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157 1292-308 PubMed GONUTS page

[PMID:16034134-4] 4.0 ^4.1 Grehan, JF et al. (2005) IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway. J. Immunol. 175 1903-10 PubMed GONUTS page

[PMID:20539013-5] 5.0 ^5.1 Turner, J et al. (2011) Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium. Am. J. Respir. Cell Mol. Biol. 44 276-84 PubMed GONUTS page

[PMID:20041150-6] Feng, J et al. (2009) Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels. PLoS ONE 4 e8480 PubMed GONUTS page

[PMID:16275384-7] Lin, W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J. Allergy Clin. Immunol. 116 1106-15 PubMed GONUTS page

[PMID:8096327-8] Minty, A et al. (1993) Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature 362 248-50 PubMed GONUTS page

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HUMAN:IL13

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