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HUMAN:IL11
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | IL11 | |
| Protein Name(s) | Interleukin-11
IL-11 Adipogenesis inhibitory factor (ECO:0000303 with PMID:1828438[1]) AGIF (ECO:0000303 with PMID:1828438[1]) | |
| External Links | ||
| UniProt | P20809 | |
| EMBL | M57765 X58377 AY207429 AK298973 AC020922 BC012506 | |
| CCDS | CCDS12923.1 CCDS59423.1 | |
| PIR | A42830 | |
| RefSeq | NP_000632.1 NP_001254647.1 | |
| UniGene | Hs.467304 | |
| PDB | 4MHL | |
| PDBsum | 4MHL | |
| ProteinModelPortal | P20809 | |
| SMR | P20809 | |
| BioGrid | 109803 | |
| DIP | DIP-3775N | |
| IntAct | P20809 | |
| MINT | MINT-1470864 | |
| STRING | 9606.ENSP00000264563 | |
| PhosphoSite | P20809 | |
| DMDM | 124294 | |
| PaxDb | P20809 | |
| PRIDE | P20809 | |
| DNASU | 3589 | |
| Ensembl | ENST00000264563 ENST00000585513 ENST00000590625 | |
| GeneID | 3589 | |
| KEGG | hsa:3589 | |
| UCSC | uc002qks.2 | |
| CTD | 3589 | |
| GeneCards | GC19M055875 | |
| HGNC | HGNC:5966 | |
| MIM | 147681 | |
| neXtProt | NX_P20809 | |
| PharmGKB | PA29781 | |
| eggNOG | NOG72895 | |
| GeneTree | ENSGT00390000007165 | |
| HOGENOM | HOG000013057 | |
| HOVERGEN | HBG003999 | |
| InParanoid | P20809 | |
| KO | K05417 | |
| OMA | MNSVCCL | |
| OrthoDB | EOG7W1569 | |
| PhylomeDB | P20809 | |
| TreeFam | TF337294 | |
| SignaLink | P20809 | |
| ChiTaRS | IL11 | |
| GeneWiki | Interleukin_11 | |
| GenomeRNAi | 3589 | |
| NextBio | 14023 | |
| PRO | PR:P20809 | |
| Proteomes | UP000005640 | |
| Bgee | P20809 | |
| CleanEx | HS_IL11 | |
| ExpressionAtlas | P20809 | |
| Genevestigator | P20809 | |
| GO | GO:0005737 GO:0005576 GO:0005615 GO:0008083 GO:0005142 GO:0030183 GO:0007267 GO:0045444 GO:0030219 GO:0046888 GO:0008284 GO:0043410 GO:0033138 GO:0050731 GO:0045944 | |
| InterPro | IPR009079 IPR020438 IPR020412 | |
| Pfam | PF07400 | |
| PRINTS | PR01943 PR01927 | |
| SUPFAM | SSF47266 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
NOT|involved_in |
GO:2000352 |
negative regulation of endothelial cell apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
NOT|involved_in |
GO:1903659 |
regulation of complement-dependent cytotoxicity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045444 |
fat cell differentiation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030219 |
megakaryocyte differentiation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030183 |
B cell differentiation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005142 |
interleukin-11 receptor binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043410 |
positive regulation of MAPK cascade |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002704120 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107613 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002704120 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107613 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107613 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046888 |
negative regulation of hormone secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043410 |
positive regulation of MAPK cascade |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47873 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47873 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005142 |
interleukin-11 receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47873 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47873 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:R-HSA-6783589 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-449976 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Kawashima, I et al. (1991) Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. FEBS Lett. 283 199-202 PubMed GONUTS page
- ↑ 2.0 2.1 Grehan, JF et al. (2005) IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway. J. Immunol. 175 1903-10 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Paul, SR et al. (1990) Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc. Natl. Acad. Sci. U.S.A. 87 7512-6 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Yin, T & Yang, YC (1994) Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells. J. Biol. Chem. 269 3731-8 PubMed GONUTS page
- ↑ Yamaguchi, M et al. (1995) Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer. Endocrinology 136 1072-8 PubMed GONUTS page
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- GO:0033138 ! positive regulation of peptidyl-serine phosphorylation
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
- GO:0043410 ! positive regulation of MAPK cascade
- GO:0008284 ! positive regulation of cell population proliferation
- Primates
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