HUMAN:IL10

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IL10
Protein Name(s)	Interleukin-10 IL-10 Cytokine synthesis inhibitory factor CSIF
External Links
UniProt	P22301
EMBL	M57627 U16720 AY029171 AF418271
CCDS	CCDS1467.1
PIR	A38580
RefSeq	NP_000563.1
UniGene	Hs.193717
PDB	1ILK 1INR 1J7V 1LK3 1Y6K 2H24 2ILK
PDBsum	1ILK 1INR 1J7V 1LK3 1Y6K 2H24 2ILK
ProteinModelPortal	P22301
SMR	P22301
BioGrid	109800
DIP	DIP-3511N
IntAct	P22301
MINT	MINT-206740
STRING	9606.ENSP00000412237
PhosphoSite	P22301
DMDM	124292
PaxDb	P22301
PRIDE	P22301
DNASU	3586
Ensembl	ENST00000423557
GeneID	3586
KEGG	hsa:3586
UCSC	uc001hen.1
CTD	3586
GeneCards	GC01M206940
HGNC	HGNC:5962
HPA	CAB013120
MIM	124092 614395
neXtProt	NX_P22301
Orphanet	238569 117 536
PharmGKB	PA29778
eggNOG	NOG43085
HOGENOM	HOG000072692
HOVERGEN	HBG004110
InParanoid	P22301
KO	K05443
OMA	PHMLREL
OrthoDB	EOG7C2R33
PhylomeDB	P22301
TreeFam	TF333253
SignaLink	P22301
EvolutionaryTrace	P22301
GeneWiki	Interleukin_10
GenomeRNAi	3586
NextBio	14011
PRO	PR:P22301
Proteomes	UP000005640
Bgee	P22301
CleanEx	HS_IL10
ExpressionAtlas	P22301
Genevestigator	P22301
GO	GO:0005615 GO:0005125 GO:0008083 GO:0005141 GO:0007568 GO:0030183 GO:0042100 GO:0060670 GO:0007267 GO:0071392 GO:0071222 GO:0007253 GO:0042742 GO:0030097 GO:0006954 GO:0030595 GO:0043066 GO:0030889 GO:0002875 GO:0002740 GO:0044130 GO:0045355 GO:0032689 GO:0032695 GO:0032715 GO:0051045 GO:0045347 GO:0030886 GO:0045019 GO:0042130 GO:0042536 GO:0002904 GO:0050715 GO:0045348 GO:0051091 GO:0045944 GO:0045893 GO:0032800 GO:0010468 GO:0045191 GO:0051930 GO:0014823 GO:0034465 GO:0042493 GO:0051384 GO:0014854 GO:0032868 GO:0002237 GO:0042092
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR000098 IPR020443 IPR020423
PANTHER	PTHR11585
Pfam	PF00726
PRINTS	PR01294
SMART	SM00188
SUPFAM	SSF47266
PROSITE	PS00520

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060302	negative regulation of cytokine activity	PMID:9847016^[1]	ECO:0000315			P		Figures 1-3	complete CACAO 1998
	GO:0050728	negative regulation of inflammatory response	PMID:9847016^[1]	ECO:0000315			P		Figures 1-3	complete
involved_in	GO:0045347	negative regulation of MHC class II biosynthetic process	PMID:1940799^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001818	negative regulation of cytokine production	PMID:1940799^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	PMID:26962683^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	PMID:16982608^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	PMID:16982608^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18893	P	regulates_o_occurs_in:(CL:0002609) part_of:(GO:0050728)	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21857966^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17875732^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q7Z7D3)	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18893	P	occurs_in:(UBERON:0005396)	Seeded From UniProt	complete
involved_in	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18893	P		Seeded From UniProt	complete
involved_in	GO:1903034	regulation of response to wounding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18893	P		Seeded From UniProt	complete
involved_in	GO:0034115	negative regulation of heterotypic cell-cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18893	P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06804	P		Seeded From UniProt	complete
involved_in	GO:0034116	positive regulation of heterotypic cell-cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06804	P		Seeded From UniProt	complete
involved_in	GO:0072577	endothelial cell apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06804	P		Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06804	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21323571^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001977)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16606666^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q7Z7D3)	Seeded From UniProt	complete
involved_in	GO:0060302	negative regulation of cytokine activity	PMID:9847016^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	PMID:16034134^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:1903659	regulation of complement-dependent cytotoxicity	PMID:16034134^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:14971032^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	PMID:10443688^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:7749983^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051045	negative regulation of membrane protein ectodomain proteolysis	PMID:18383040^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050715	positive regulation of cytokine secretion	PMID:10443688^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:7749983^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042130	negative regulation of T cell proliferation	PMID:14971032^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032800	receptor biosynthetic process	PMID:10443688^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	PMID:10443688^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:10443688^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10443688^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:10443688^[11]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002740	negative regulation of cytokine secretion involved in immune response	PMID:10443688^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045355	negative regulation of interferon-alpha biosynthetic process	PMID:9637497^[14]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045191	regulation of isotype switching	PMID:8228801^[15]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:8312229^[16]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042130	negative regulation of T cell proliferation	PMID:8499633^[17]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042100	B cell proliferation	PMID:8228801^[15]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	PMID:8228801^[15]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:1371884^[18]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007253	cytoplasmic sequestering of NF-kappaB	PMID:10975994^[19]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005141	interleukin-10 receptor binding	PMID:1847510^[20]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002237	response to molecule of bacterial origin	PMID:17449476^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030889	negative regulation of B cell proliferation	PMID:9184696^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:9184696^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002904	positive regulation of B cell apoptotic process	PMID:9184696^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:1903034	regulation of response to wounding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0060670	branching involved in labyrinthine layer morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0045348	positive regulation of MHC class II biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0044130	negative regulation of growth of symbiont in host	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0042832	defense response to protozoan	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0035729	cellular response to hepatocyte growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0034115	negative regulation of heterotypic cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0032695	negative regulation of interleukin-12 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0032689	negative regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0030886	negative regulation of myeloid dendritic cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	F		Seeded From UniProt	complete
involved_in	GO:0002875	negative regulation of chronic inflammatory response to antigenic stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18893 ensembl:ENSMUSP00000016673	P		Seeded From UniProt	complete
involved_in	GO:1904057	negative regulation of sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0051930	regulation of sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0045019	negative regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0043032	positive regulation of macrophage activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0034465	response to carbon monoxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0014854	response to inactivity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	C		Seeded From UniProt	complete
enables	GO:0005141	interleukin-10 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	F		Seeded From UniProt	complete
involved_in	GO:0001818	negative regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29456 ensembl:ENSRNOP00000006246	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000098	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000098	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000098	P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	PMID:19262501^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071650	negative regulation of chemokine (C-C motif) ligand 5 production	PMID:19262501^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032717	negative regulation of interleukin-8 production	PMID:19262501^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032701	negative regulation of interleukin-18 production	PMID:19262501^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032695	negative regulation of interleukin-12 production	PMID:19262501^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	PMID:19262501^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032692	negative regulation of interleukin-1 production	PMID:19262501^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030595	leukocyte chemotaxis	PMID:9405662^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045347	negative regulation of MHC class II biosynthetic process	PMID:11244051^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042092	type 2 immune response	PMID:11244051^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030097	hemopoiesis	PMID:11244051^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035722	interleukin-12-mediated signaling pathway	Reactome:R-HSA-9020591	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807 Reactome:R-HSA-6783783	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-8981073 Reactome:R-HSA-6789615 Reactome:R-HSA-6784791 Reactome:R-HSA-6784324 Reactome:R-HSA-6784323 Reactome:R-HSA-6784319 Reactome:R-HSA-6784006 Reactome:R-HSA-449855 Reactome:R-HSA-449811 Reactome:R-HSA-449803	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Hawkins, DL et al. (1998) Human interleukin 10 suppresses production of inflammatory mediators by LPS-stimulated equine peritoneal macrophages. Vet. Immunol. Immunopathol. 66 1-10 PubMed GONUTS page
↑ ^2.0 ^2.1 de Waal Malefyt, R et al. (1991) Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174 1209-20 PubMed GONUTS page
↑ Shi, J et al. (2016) IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways. Cell Death Dis 7 e2133 PubMed GONUTS page
↑ ^4.0 ^4.1 Yoon, SI et al. (2006) Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. J. Biol. Chem. 281 35088-96 PubMed GONUTS page
↑ Li, B et al. (2011) WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity. PLoS ONE 6 e22920 PubMed GONUTS page
↑ Kryczek, I et al. (2007) Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma. Cancer Res. 67 8900-5 PubMed GONUTS page
↑ Khan, DA et al. (2011) Pro/anti-inflammatory cytokines in the pathogenesis of premature coronary artery disease. J. Interferon Cytokine Res. 31 561-7 PubMed GONUTS page
↑ Kryczek, I et al. (2006) B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J. Exp. Med. 203 871-81 PubMed GONUTS page
↑ ^9.0 ^9.1 Grehan, JF et al. (2005) IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway. J. Immunol. 175 1903-10 PubMed GONUTS page
↑ ^10.0 ^10.1 Beinhauer, BG et al. (2004) Interleukin 10 regulates cell surface and soluble LIR-2 (CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro. Eur. J. Immunol. 34 74-80 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Franchimont, D et al. (1999) Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor. J. Clin. Endocrinol. Metab. 84 2834-9 PubMed GONUTS page
↑ ^12.0 ^12.1 Stüber, E et al. (1995) Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity 2 507-21 PubMed GONUTS page
↑ Brennan, FM et al. (2008) Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism. Eur. J. Immunol. 38 1106-17 PubMed GONUTS page
↑ Payvandi, F et al. (1998) Exogenous and endogenous IL-10 regulate IFN-alpha production by peripheral blood mononuclear cells in response to viral stimulation. J. Immunol. 160 5861-8 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Fluckiger, AC et al. (1993) Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes. J. Exp. Med. 178 1473-81 PubMed GONUTS page
↑ Taga, K et al. (1993) IL-10 inhibits apoptotic cell death in human T cells starved of IL-2. Int. Immunol. 5 1599-608 PubMed GONUTS page
↑ Taga, K et al. (1993) Human interleukin-10 can directly inhibit T-cell growth. Blood 81 2964-71 PubMed GONUTS page
↑ Rousset, F et al. (1992) Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 89 1890-3 PubMed GONUTS page
↑ Raychaudhuri, B et al. (2000) Interleukin 10 (IL-10)-mediated inhibition of inflammatory cytokine production by human alveolar macrophages. Cytokine 12 1348-55 PubMed GONUTS page
↑ Vieira, P et al. (1991) Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. Proc. Natl. Acad. Sci. U.S.A. 88 1172-6 PubMed GONUTS page
↑ Lella, RK & Sharma, C (2007) Eis (enhanced intracellular survival) protein of Mycobacterium tuberculosis disturbs the cross regulation of T-cells. J. Biol. Chem. 282 18671-5 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Li, L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell. Immunol. 178 33-41 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 Booth, JS et al. (2009) A novel regulatory B-cell population in sheep Peyer's patches spontaneously secretes IL-10 and downregulates TLR9-induced IFNalpha responses. Mucosal Immunol 2 265-75 PubMed GONUTS page
↑ Gesser, B et al. (1997) Identification of functional domains on human interleukin 10. Proc. Natl. Acad. Sci. U.S.A. 94 14620-5 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Moore, KW et al. (2001) Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19 683-765 PubMed GONUTS page

[PMID:9847016-1] 1.0 ^1.1 ^1.2 Hawkins, DL et al. (1998) Human interleukin 10 suppresses production of inflammatory mediators by LPS-stimulated equine peritoneal macrophages. Vet. Immunol. Immunopathol. 66 1-10 PubMed GONUTS page

[PMID:1940799-2] 2.0 ^2.1 de Waal Malefyt, R et al. (1991) Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174 1209-20 PubMed GONUTS page

[PMID:26962683-3] Shi, J et al. (2016) IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways. Cell Death Dis 7 e2133 PubMed GONUTS page

[PMID:16982608-4] 4.0 ^4.1 Yoon, SI et al. (2006) Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. J. Biol. Chem. 281 35088-96 PubMed GONUTS page

[PMID:21857966-5] Li, B et al. (2011) WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity. PLoS ONE 6 e22920 PubMed GONUTS page

[PMID:17875732-6] Kryczek, I et al. (2007) Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma. Cancer Res. 67 8900-5 PubMed GONUTS page

[PMID:21323571-7] Khan, DA et al. (2011) Pro/anti-inflammatory cytokines in the pathogenesis of premature coronary artery disease. J. Interferon Cytokine Res. 31 561-7 PubMed GONUTS page

[PMID:16606666-8] Kryczek, I et al. (2006) B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J. Exp. Med. 203 871-81 PubMed GONUTS page

[PMID:16034134-9] 9.0 ^9.1 Grehan, JF et al. (2005) IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway. J. Immunol. 175 1903-10 PubMed GONUTS page

[PMID:14971032-10] 10.0 ^10.1 Beinhauer, BG et al. (2004) Interleukin 10 regulates cell surface and soluble LIR-2 (CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro. Eur. J. Immunol. 34 74-80 PubMed GONUTS page

[PMID:10443688-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Franchimont, D et al. (1999) Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor. J. Clin. Endocrinol. Metab. 84 2834-9 PubMed GONUTS page

[PMID:7749983-12] 12.0 ^12.1 Stüber, E et al. (1995) Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity 2 507-21 PubMed GONUTS page

[PMID:18383040-13] Brennan, FM et al. (2008) Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism. Eur. J. Immunol. 38 1106-17 PubMed GONUTS page

[PMID:9637497-14] Payvandi, F et al. (1998) Exogenous and endogenous IL-10 regulate IFN-alpha production by peripheral blood mononuclear cells in response to viral stimulation. J. Immunol. 160 5861-8 PubMed GONUTS page

[PMID:8228801-15] 15.0 ^15.1 ^15.2 Fluckiger, AC et al. (1993) Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes. J. Exp. Med. 178 1473-81 PubMed GONUTS page

[PMID:8312229-16] Taga, K et al. (1993) IL-10 inhibits apoptotic cell death in human T cells starved of IL-2. Int. Immunol. 5 1599-608 PubMed GONUTS page

[PMID:8499633-17] Taga, K et al. (1993) Human interleukin-10 can directly inhibit T-cell growth. Blood 81 2964-71 PubMed GONUTS page

[PMID:1371884-18] Rousset, F et al. (1992) Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 89 1890-3 PubMed GONUTS page

[PMID:10975994-19] Raychaudhuri, B et al. (2000) Interleukin 10 (IL-10)-mediated inhibition of inflammatory cytokine production by human alveolar macrophages. Cytokine 12 1348-55 PubMed GONUTS page

[PMID:1847510-20] Vieira, P et al. (1991) Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. Proc. Natl. Acad. Sci. U.S.A. 88 1172-6 PubMed GONUTS page

[PMID:17449476-21] Lella, RK & Sharma, C (2007) Eis (enhanced intracellular survival) protein of Mycobacterium tuberculosis disturbs the cross regulation of T-cells. J. Biol. Chem. 282 18671-5 PubMed GONUTS page

[PMID:9184696-22] 22.0 ^22.1 ^22.2 Li, L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell. Immunol. 178 33-41 PubMed GONUTS page

[PMID:19262501-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 Booth, JS et al. (2009) A novel regulatory B-cell population in sheep Peyer's patches spontaneously secretes IL-10 and downregulates TLR9-induced IFNalpha responses. Mucosal Immunol 2 265-75 PubMed GONUTS page

[PMID:9405662-24] Gesser, B et al. (1997) Identification of functional domains on human interleukin 10. Proc. Natl. Acad. Sci. U.S.A. 94 14620-5 PubMed GONUTS page

[PMID:11244051-25] 25.0 ^25.1 ^25.2 Moore, KW et al. (2001) Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19 683-765 PubMed GONUTS page

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