HUMAN:IHH

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IHH
Protein Name(s)	Indian hedgehog protein IHH HHG-2 Indian hedgehog protein N-product Indian hedgehog protein C-product
External Links
UniProt	Q14623
EMBL	AB018076 CH471063 BC034757 BC136587 BC136588 L38517
CCDS	CCDS33380.1
RefSeq	NP_002172.2
UniGene	Hs.654504
PDB	3K7G 3K7H 3K7I 3K7J 3N1F 3N1M 3N1O 3N1P
PDBsum	3K7G 3K7H 3K7I 3K7J 3N1F 3N1M 3N1O 3N1P
ProteinModelPortal	Q14623
SMR	Q14623
BioGrid	109765
IntAct	Q14623
STRING	9606.ENSP00000295731
MEROPS	C46.003
iPTMnet	Q14623
PhosphoSitePlus	Q14623
BioMuta	IHH
DMDM	33112634
EPD	Q14623
MaxQB	Q14623
PaxDb	Q14623
PeptideAtlas	Q14623
PRIDE	Q14623
Ensembl	ENST00000295731
GeneID	3549
KEGG	hsa:3549
UCSC	uc002vjo.3
CTD	3549
DisGeNET	3549
GeneCards	IHH
H-InvDB	HIX0023995
HGNC	HGNC:5956
MalaCards	IHH
MIM	112500 600726 607778
neXtProt	NX_Q14623
OpenTargets	ENSG00000163501
Orphanet	63446 93388
PharmGKB	PA29769
eggNOG	KOG3638 ENOG410XQA3
GeneTree	ENSGT00390000001117
HOGENOM	HOG000233428
HOVERGEN	HBG005480
InParanoid	Q14623
KO	K11989
OMA	LGEGVHW
OrthoDB	EOG091G0N90
PhylomeDB	Q14623
TreeFam	TF106458
Reactome	[www.reactome.org/content/detail/R-HSA-373080 R-HSA-373080] [www.reactome.org/content/detail/R-HSA-5358346 R-HSA-5358346] [www.reactome.org/content/detail/R-HSA-5362798 R-HSA-5362798] [www.reactome.org/content/detail/R-HSA-5632681 R-HSA-5632681] [www.reactome.org/content/detail/R-HSA-5632684 R-HSA-5632684] [www.reactome.org/content/detail/R-HSA-5635838 R-HSA-5635838] [www.reactome.org/content/detail/R-HSA-5658034 R-HSA-5658034]
SignaLink	Q14623
SIGNOR	Q14623
EvolutionaryTrace	Q14623
GeneWiki	IHH_(protein)
GenomeRNAi	3549
PRO	PR:Q14623
Proteomes	UP000005640
Bgee	ENSG00000163501
CleanEx	HS_IHH
Genevisible	Q14623
GO	GO:0005615 GO:0005886 GO:0005509 GO:0005113 GO:0008233 GO:0051216 GO:0007267 GO:0042733 GO:0001947 GO:0016539 GO:0060135 GO:0046639 GO:0043066 GO:0033088 GO:0009968 GO:0033085 GO:0046638 GO:0032332 GO:0050679 GO:0045880 GO:0033089 GO:0045944 GO:0032355 GO:0001501 GO:0007224 GO:0061053
Gene3D	2.170.16.10 3.30.1380.10
InterPro	IPR001657 IPR028992 IPR009045 IPR000320 IPR001767 IPR003586 IPR003587 IPR033385 IPR006141
PANTHER	PTHR11889:SF57
Pfam	PF01085 PF01079
PIRSF	PIRSF009400
PRINTS	PR00632
SMART	SM00305 SM00306
SUPFAM	SSF51294 SSF55166
PROSITE	PS50817

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
Contributes to	GO:0005113	patched binding	PMID:21537345^[1]	ECO:0000314			F	Indian Hedgehog proteins facilitate binding to the patched (PTC1)receptor in order to interact with foreign cells. Mutations of Indian Hedgehog (IHH) proteins are the cause of the disorder Brachydactyly type A1(BDA1), which physically causes an underdevelopment in digits where the second and third phalanges are either fused together or do not completely form. Fig.4 shows the effects on receptor-binding ability to a patched receptor when the hedgehog protein hosts a mutation. Fig.4A graphs the percentage of protein binding to a PTC1 receptor versus the amount of the protein present (in respect to the wild type human protein, and two BDA1 mutation proteins). Fig. 4B shows that the BDA1 mutations have a significantly decreased binding activity level in comparison to the human protein. These results are analyzed from figure S2, which displays the incubated assay results of the wild type and mutated proteins.	complete CACAO 12661
involved_in	GO:0061053	somite development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97812	P	Seeded From UniProt	complete
involved_in	GO:0046639	negative regulation of alpha-beta T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97812	P	Seeded From UniProt	complete
involved_in	GO:0046638	positive regulation of alpha-beta T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97812	P	Seeded From UniProt	complete
involved_in	GO:0045880	positive regulation of smoothened signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97812	P	Seeded From UniProt	complete
involved_in	GO:0033089	positive regulation of T cell differentiation in thymus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97812	P	Seeded From UniProt	complete
involved_in	GO:0033088	negative regulation of immature T cell proliferation in thymus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97812	P	Seeded From UniProt	complete
involved_in	GO:0033085	negative regulation of T cell differentiation in thymus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97812	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97812	P	Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:21537345^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21537345^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21537345^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005113	patched binding	PMID:21537345^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q61115	F	Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	PMID:21537345^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96533 MGI:MGI:98297 PANTHER:PTN001726121 UniProtKB:F1P3J4 UniProtKB:Q15465 UniProtKB:Q91035 UniProtKB:Q98938 ZFIN:ZDB-GENE-980526-166	P	Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004644 MGI:MGI:94891 MGI:MGI:96533 MGI:MGI:98297 PANTHER:PTN001726121 UniProtKB:Q14623 UniProtKB:Q15465 UniProtKB:Q98938 ZFIN:ZDB-GENE-051010-1 ZFIN:ZDB-GENE-980526-166	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004644 MGI:MGI:98297 PANTHER:PTN001726121 RGD:3673 UniProtKB:F1P3J4 UniProtKB:Q15465 UniProtKB:Q91035 UniProtKB:Q98938	C	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001726121 UniProtKB:O43323 UniProtKB:Q14623 UniProtKB:Q15465	F	Seeded From UniProt	complete
enables	GO:0005113	patched binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94891 MGI:MGI:96533 MGI:MGI:98297 PANTHER:PTN001726121 UniProtKB:Q14623 UniProtKB:Q15465	F	Seeded From UniProt	complete
involved_in	GO:0001708	cell fate specification	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96533 MGI:MGI:98297 PANTHER:PTN001726121 RGD:3673 ZFIN:ZDB-GENE-980526-166	P	Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LP42 ensembl:ENSRNOP00000024419	P	Seeded From UniProt	complete
involved_in	GO:0060135	maternal process involved in female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LP42 ensembl:ENSRNOP00000024419	P	Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LP42 ensembl:ENSRNOP00000024419	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LP42 ensembl:ENSRNOP00000024419	P	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LP42 ensembl:ENSRNOP00000024419	P	Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LP42 ensembl:ENSRNOP00000024419	P	Seeded From UniProt	complete
involved_in	GO:0046639	negative regulation of alpha-beta T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0046638	positive regulation of alpha-beta T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0045880	positive regulation of smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0045596	negative regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0045453	bone resorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0043010	camera-type eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0035988	chondrocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0035264	multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0033089	positive regulation of T cell differentiation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0033088	negative regulation of immature T cell proliferation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0033085	negative regulation of T cell differentiation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0031016	pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	C	Seeded From UniProt	complete
involved_in	GO:0030704	vitelline membrane formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0006029	proteoglycan metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
enables	GO:0005113	patched binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	F	Seeded From UniProt	complete
involved_in	GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0003406	retinal pigment epithelium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0003382	epithelial cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0001944	vasculature development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0001763	morphogenesis of a branching structure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0001708	cell fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0090136	epithelial cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0072498	embryonic skeletal joint development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0061053	somite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0060323	head morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0060220	camera-type eye photoreceptor cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0048745	smooth muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0048596	embryonic camera-type eye morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0048557	embryonic digestive tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0048469	cell maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0048074	negative regulation of eye pigmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97812 ensembl:ENSMUSP00000128056	P	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001767	P	Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000320 InterPro:IPR001657	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001657	P	Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001767	F	Seeded From UniProt	complete
involved_in	GO:0016539	intein-mediated protein splicing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006141	P	Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	PMID:17889828^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	PMID:17889828^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0112	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Ma, G et al. (2011) Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels. Cell Res. 21 1343-57 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Zhou, J et al. (2007) IHH and FGF8 coregulate elongation of digit primordia. Biochem. Biophys. Res. Commun. 363 513-8 PubMed GONUTS page

[PMID:21537345-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Ma, G et al. (2011) Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels. Cell Res. 21 1343-57 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17889828-3] 3.0 ^3.1 Zhou, J et al. (2007) IHH and FGF8 coregulate elongation of digit primordia. Biochem. Biophys. Res. Commun. 363 513-8 PubMed GONUTS page

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HUMAN:IHH

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