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HUMAN:IFT88

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) IFT88 (synonyms: TG737, TTC10)
Protein Name(s) Intraflagellar transport protein 88 homolog

Recessive polycystic kidney disease protein Tg737 homolog Tetratricopeptide repeat protein 10 TPR repeat protein 10

External Links
UniProt Q13099
EMBL U20362
AK300769
AL161772
AL590096
AL590096
AL161772
AL161772
AL590096
AL590096
AL161772
CH471075
BC030776
CCDS CCDS31944.1
CCDS31945.1
RefSeq NP_006522.2
NP_783195.2
XP_005266610.1
XP_006719932.1
XP_006719933.1
UniGene Hs.187376
ProteinModelPortal Q13099
SMR Q13099
BioGrid 113771
IntAct Q13099
STRING 9606.ENSP00000323580
PhosphoSite Q13099
DMDM 206729873
MaxQB Q13099
PaxDb Q13099
PRIDE Q13099
DNASU 8100
Ensembl ENST00000319980
ENST00000351808
GeneID 8100
KEGG hsa:8100
UCSC uc001unh.3
CTD 8100
GeneCards GC13P021141
HGNC HGNC:20606
HPA HPA040731
MIM 600595
neXtProt NX_Q13099
Orphanet 474
564
PharmGKB PA134991804
eggNOG COG0457
GeneTree ENSGT00390000015473
HOGENOM HOG000258203
HOVERGEN HBG059328
InParanoid Q13099
KO K16474
OMA LILCYYA
OrthoDB EOG7N37D5
PhylomeDB Q13099
TreeFam TF313218
Reactome REACT_267634
ChiTaRS IFT88
GeneWiki IFT88
GenomeRNAi 8100
NextBio 30744
PRO PR:Q13099
Proteomes UP000005640
Bgee Q13099
CleanEx HS_IFT88
ExpressionAtlas Q13099
Genevestigator Q13099
GO GO:0002080
GO:0045177
GO:0097541
GO:0005814
GO:0036064
GO:0097546
GO:0097542
GO:0005929
GO:0030992
GO:0060091
GO:0031514
GO:0031512
GO:0032391
GO:0009952
GO:0055007
GO:0060411
GO:0060271
GO:0090102
GO:0031122
GO:0007368
GO:0042733
GO:0036334
GO:0008544
GO:0003382
GO:0001654
GO:0048853
GO:0060914
GO:0060122
GO:0001822
GO:0001889
GO:0060426
GO:0050680
GO:0007219
GO:0060021
GO:0031016
GO:0043568
GO:0008104
GO:2000785
GO:1902017
GO:0045598
GO:0042487
GO:0070613
GO:0008589
GO:0034405
GO:0007224
GO:0007288
GO:0007290
GO:0021513
GO:0021537
Gene3D 1.25.40.10
InterPro IPR006597
IPR013026
IPR011990
IPR001440
IPR013105
IPR019734
Pfam PF00515
PF07719
PF13174
PF13181
SMART SM00671
SM00028
PROSITE PS50005
PS50293

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0036126

sperm flagellum

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61371

C

Seeded From UniProt

complete

part_of

GO:0036064

ciliary basal body

PMID:27767179[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:27767179[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:28428259[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0036064

ciliary basal body

PMID:28428259[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0036064

ciliary basal body

PMID:28625565[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005814

centriole

PMID:27623382[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030992

intraciliary transport particle B

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61371

C

Seeded From UniProt

complete

part_of

GO:0031514

motile cilium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9FPW0

C

Seeded From UniProt

complete

part_of

GO:0030992

intraciliary transport particle B

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9FPW0

C

Seeded From UniProt

complete

involved_in

GO:2000785

regulation of autophagosome assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61371

P

Seeded From UniProt

complete

involved_in

GO:1902017

regulation of cilium assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61371

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61371

P

Seeded From UniProt

complete

part_of

GO:0036064

ciliary basal body

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61371

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61371

C

Seeded From UniProt

complete

part_of

GO:0005814

centriole

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61371

C

Seeded From UniProt

complete

involved_in

GO:1905515

non-motile cilium assembly

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0016919
MGI:MGI:98715
PANTHER:PTN000555524
WB:WBGene00003885

P

Seeded From UniProt

complete

part_of

GO:0097730

non-motile cilium

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0016919
MGI:MGI:98715
PANTHER:PTN000555524
WB:WBGene00003885

C

Seeded From UniProt

complete

part_of

GO:0097546

ciliary base

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98715
PANTHER:PTN000555524

C

Seeded From UniProt

complete

involved_in

GO:0060122

inner ear receptor cell stereocilium organization

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98715
PANTHER:PTN002891187

P

Seeded From UniProt

complete

part_of

GO:0036064

ciliary basal body

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98715
PANTHER:PTN000555524
UniProtKB:Q13099
WB:WBGene00003885

C

Seeded From UniProt

complete

enables

GO:0019894

kinesin binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98715
PANTHER:PTN000555524

F

Seeded From UniProt

complete

part_of

GO:0005814

centriole

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98715
PANTHER:PTN000555524
UniProtKB:Q13099

C

Seeded From UniProt

complete

involved_in

GO:0001822

kidney development

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98715
PANTHER:PTN002891187

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:24421332[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0097542

ciliary tip

Reactome:R-HSA-5625426
Reactome:R-HSA-5625421
Reactome:R-HSA-5625416
Reactome:R-HSA-5624952

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

involved_in

GO:0035735

intraciliary transport involved in cilium assembly

Reactome:R-HSA-5620924

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

Reactome:R-HSA-5625426
Reactome:R-HSA-5625424
Reactome:R-HSA-5625416
Reactome:R-HSA-5624949

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0969
UniProtKB-SubCell:SL-0066

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0031514

motile cilium

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0282
UniProtKB-SubCell:SL-0117

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0030030

cell projection organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0970

P

Seeded From UniProt

complete

part_of

GO:0005814

centriole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0046

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Yu, F et al. (2016) The serologically defined colon cancer antigen-3 (SDCCAG3) is involved in the regulation of ciliogenesis. Sci Rep 6 35399 PubMed GONUTS page
  2. 2.0 2.1 Nishijima, Y et al. (2017) RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly. Mol. Biol. Cell 28 1652-1666 PubMed GONUTS page
  3. Kanie, T et al. (2017) The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Dev. Cell 42 22-36.e12 PubMed GONUTS page
  4. Nechipurenko, IV et al. (2016) A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis. Dev. Cell 38 493-506 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. Kobayashi, T et al. (2014) The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. J. Cell Biol. 204 215-29 PubMed GONUTS page