HUMAN:IFNB

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IFNB1 (synonyms: IFB, IFNB)
Protein Name(s)	Interferon beta IFN-beta Fibroblast interferon
External Links
UniProt	P01574
EMBL	V00534 V00535 V00546 V00547 M28622 EF064725 AB451323 AB451452 CH471071 BC069314 BC096150 BC096151 BC096152 BC096153
CCDS	CCDS6495.1
PIR	A93721
RefSeq	NP_002167.1
UniGene	Hs.93177
PDB	1AU1
PDBsum	1AU1
ProteinModelPortal	P01574
SMR	P01574
BioGrid	109678
DIP	DIP-6018N
STRING	9606.ENSP00000369581
Allergome	9875
PhosphoSite	P01574
DMDM	124469
PaxDb	P01574
PRIDE	P01574
Ensembl	ENST00000380232
GeneID	3456
KEGG	hsa:3456
UCSC	uc003zok.3
CTD	3456
GeneCards	GC09M021077
HGNC	HGNC:5434
HPA	CAB009386
MIM	147640
neXtProt	NX_P01574
PharmGKB	PA29672
eggNOG	NOG43895
GeneTree	ENSGT00760000119150
HOGENOM	HOG000230501
HOVERGEN	HBG052086
InParanoid	P01574
KO	K05415
OMA	NGRLEYC
OrthoDB	EOG7J9VRD
PhylomeDB	P01574
TreeFam	TF336177
Reactome	REACT_169436 REACT_24938 REACT_24970 REACT_25026 REACT_25162 REACT_25216
SignaLink	P01574
EvolutionaryTrace	P01574
GeneWiki	IFNB1
GenomeRNAi	3456
NextBio	13618
PMAP-CutDB	P01574
PRO	PR:P01574
Proteomes	UP000005640
CleanEx	HS_IFNB1
ExpressionAtlas	P01574
Genevestigator	P01574
GO	GO:0005576 GO:0005615 GO:0005125 GO:0005132 GO:0002250 GO:0002312 GO:0030183 GO:0042100 GO:0007596 GO:0007166 GO:0071360 GO:0035458 GO:0019221 GO:0042742 GO:0051607 GO:0006959 GO:0045087 GO:0030101 GO:0002323 GO:0045581 GO:2000552 GO:0045071 GO:2001235 GO:0045089 GO:0033141 GO:0045944 GO:0045343 GO:0060338 GO:0043330 GO:0009615 GO:0002286 GO:0060337
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR000471 IPR015588
PANTHER	PTHR11691 PTHR11691:SF7
Pfam	PF00143
PRINTS	PR00266
SMART	SM00076
SUPFAM	SSF47266
PROSITE	PS00252

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:19008854^[1]	ECO:0000314			P		Figure 1E panel 3 and 4A show that IFN-β induces the expression of P56 (IFIT1).	complete
	GO:0045071	negative regulation of viral genome replication	PMID:19008854^[1]	ECO:0000314			P		Figure 4B and 4C confirm that IFN-β inhibits HPV DNA replication.	complete
enables	GO:0008811	chloramphenicol O-acetyltransferase activity	PMID:19176627^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060337	type I interferon signaling pathway	PMID:18035482^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035458	cellular response to interferon-beta	PMID:18035482^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18035482^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q6GPH4) part_of:(GO:0035458)\|has_regulation_target(UniProtKB:Q6GPH4) part_of:(GO:0060337)	Seeded From UniProt	complete
involved_in	GO:0045071	negative regulation of viral genome replication	PMID:19008854^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	PMID:18035482^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P42224) part_of:(GO:0035458)\|has_regulation_target(UniProtKB:P42224) part_of:(GO:0060337)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:19008854^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2001235	positive regulation of apoptotic signaling pathway	PMID:10918594^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001235	positive regulation of apoptotic signaling pathway	PMID:11337497^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000552	negative regulation of T-helper 2 cell cytokine production	PMID:20554961^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045581	negative regulation of T cell differentiation	PMID:20554961^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045343	regulation of MHC class I biosynthetic process	PMID:8805651^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045089	positive regulation of innate immune response	PMID:11987821^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042100	B cell proliferation	PMID:3135963^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030101	natural killer cell activation	PMID:11987821^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:12120696^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005132	type I interferon receptor binding	PMID:2414376^[11]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002312	B cell activation involved in immune response	PMID:12932356^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043330	response to exogenous dsRNA	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000914537 UniProtKB:P01574	P		Seeded From UniProt	complete
involved_in	GO:0042100	B cell proliferation	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107657 PANTHER:PTN000914537	P		Seeded From UniProt	complete
involved_in	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000914537 UniProtKB:P01574	P		Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2448469 PANTHER:PTN000914537	P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2448469 PANTHER:PTN000914537 UniProtKB:Q9P0W0	P		Seeded From UniProt	complete
involved_in	GO:0006959	humoral immune response	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107657 PANTHER:PTN000914537	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107657 MGI:MGI:107659 MGI:MGI:107662 MGI:MGI:107664 MGI:MGI:107668 PANTHER:PTN000914537	C		Seeded From UniProt	complete
enables	GO:0005132	type I interferon receptor binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107657 MGI:MGI:2448469 PANTHER:PTN000914537 UniProtKB:Q9P0W0	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107657 MGI:MGI:107668 PANTHER:PTN000914537 UniProtKB:P01574	F		Seeded From UniProt	complete
involved_in	GO:0002323	natural killer cell activation involved in immune response	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107659 MGI:MGI:107664 MGI:MGI:107668 PANTHER:PTN000914537	P		Seeded From UniProt	complete
involved_in	GO:0002286	T cell activation involved in immune response	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107668 PANTHER:PTN000914537	P		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107657 PANTHER:PTN000914537	P		Seeded From UniProt	complete
involved_in	GO:0043330	response to exogenous dsRNA	PMID:21266579^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
enables	GO:0005126	cytokine receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000471	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000471	C		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000471	P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:10640778^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071360	cellular response to exogenous dsRNA	PMID:21266579^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:19416887^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060337	type I interferon signaling pathway	Reactome:R-HSA-909733	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	Reactome:R-HSA-109582	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-997314 Reactome:R-HSA-997311 Reactome:R-HSA-997309 Reactome:R-HSA-994034 Reactome:R-HSA-9604499 Reactome:R-HSA-909732 Reactome:R-HSA-909730 Reactome:R-HSA-909729 Reactome:R-HSA-909726 Reactome:R-HSA-909724 Reactome:R-HSA-909722 Reactome:R-HSA-909720 Reactome:R-HSA-909719 Reactome:R-HSA-909718 Reactome:R-HSA-1028812	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Terenzi, F et al. (2008) Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1. EMBO J. 27 3311-21 PubMed GONUTS page
↑ Saira, K et al. (2009) The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity. J. Virol. 83 3977-81 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Sun, Y et al. (2008) Regulation of XAF1 expression in human colon cancer cell by interferon beta: activation by the transcription regulator STAT1. Cancer Lett. 260 62-71 PubMed GONUTS page
↑ Sancéau, J et al. (2000) IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7. Oncogene 19 3372-83 PubMed GONUTS page
↑ Morrison, BH et al. (2001) Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells. J. Biol. Chem. 276 24965-70 PubMed GONUTS page
↑ ^6.0 ^6.1 Huber, JP et al. (2010) Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3. J. Immunol. 185 813-7 PubMed GONUTS page
↑ Garofalo, R et al. (1996) Respiratory syncytial virus infection of human respiratory epithelial cells up-regulates class I MHC expression through the induction of IFN-beta and IL-1 alpha. J. Immunol. 157 2506-13 PubMed GONUTS page
↑ ^8.0 ^8.1 Biron, CA et al. (2002) Innate immune responses to LCMV infections: natural killer cells and cytokines. Curr. Top. Microbiol. Immunol. 263 7-27 PubMed GONUTS page
↑ Francois, DT et al. (1988) Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens. Clin. Immunol. Immunopathol. 48 297-306 PubMed GONUTS page
↑ Hong, J et al. (2002) Anti-viral properties of interferon beta treatment in patients with multiple sclerosis. Mult. Scler. 8 237-42 PubMed GONUTS page
↑ May, LT & Sehgal, PB (1985) On the relationship between human interferon alpha 1 and beta 1 genes. J. Interferon Res. 5 521-6 PubMed GONUTS page
↑ Jego, G et al. (2003) Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity 19 225-34 PubMed GONUTS page
↑ ^13.00 ^13.01 ^13.02 ^13.03 ^13.04 ^13.05 ^13.06 ^13.07 ^13.08 ^13.09 ^13.10 ^13.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^14.0 ^14.1 Watanabe, A et al. (2011) Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation. J. Biol. Chem. 286 10702-11 PubMed GONUTS page
↑ Cremer, I et al. (2000) Retrovirally mediated IFN-beta transduction of macrophages induces resistance to HIV, correlated with up-regulation of RANTES production and down-regulation of C-C chemokine receptor-5 expression. J. Immunol. 164 1582-7 PubMed GONUTS page
↑ Li, Y et al. (2009) ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response. Proc. Natl. Acad. Sci. U.S.A. 106 7945-50 PubMed GONUTS page

[PMID:19008854-1] 1.0 ^1.1 ^1.2 ^1.3 Terenzi, F et al. (2008) Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1. EMBO J. 27 3311-21 PubMed GONUTS page

[PMID:19176627-2] Saira, K et al. (2009) The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity. J. Virol. 83 3977-81 PubMed GONUTS page

[PMID:18035482-3] 3.0 ^3.1 ^3.2 ^3.3 Sun, Y et al. (2008) Regulation of XAF1 expression in human colon cancer cell by interferon beta: activation by the transcription regulator STAT1. Cancer Lett. 260 62-71 PubMed GONUTS page

[PMID:10918594-4] Sancéau, J et al. (2000) IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7. Oncogene 19 3372-83 PubMed GONUTS page

[PMID:11337497-5] Morrison, BH et al. (2001) Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells. J. Biol. Chem. 276 24965-70 PubMed GONUTS page

[PMID:20554961-6] 6.0 ^6.1 Huber, JP et al. (2010) Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3. J. Immunol. 185 813-7 PubMed GONUTS page

[PMID:8805651-7] Garofalo, R et al. (1996) Respiratory syncytial virus infection of human respiratory epithelial cells up-regulates class I MHC expression through the induction of IFN-beta and IL-1 alpha. J. Immunol. 157 2506-13 PubMed GONUTS page

[PMID:11987821-8] 8.0 ^8.1 Biron, CA et al. (2002) Innate immune responses to LCMV infections: natural killer cells and cytokines. Curr. Top. Microbiol. Immunol. 263 7-27 PubMed GONUTS page

[PMID:3135963-9] Francois, DT et al. (1988) Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens. Clin. Immunol. Immunopathol. 48 297-306 PubMed GONUTS page

[PMID:12120696-10] Hong, J et al. (2002) Anti-viral properties of interferon beta treatment in patients with multiple sclerosis. Mult. Scler. 8 237-42 PubMed GONUTS page

[PMID:2414376-11] May, LT & Sehgal, PB (1985) On the relationship between human interferon alpha 1 and beta 1 genes. J. Interferon Res. 5 521-6 PubMed GONUTS page

[PMID:12932356-12] Jego, G et al. (2003) Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity 19 225-34 PubMed GONUTS page

[PMID:21873635-13] 13.00 ^13.01 ^13.02 ^13.03 ^13.04 ^13.05 ^13.06 ^13.07 ^13.08 ^13.09 ^13.10 ^13.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21266579-14] 14.0 ^14.1 Watanabe, A et al. (2011) Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation. J. Biol. Chem. 286 10702-11 PubMed GONUTS page

[PMID:10640778-15] Cremer, I et al. (2000) Retrovirally mediated IFN-beta transduction of macrophages induces resistance to HIV, correlated with up-regulation of RANTES production and down-regulation of C-C chemokine receptor-5 expression. J. Immunol. 164 1582-7 PubMed GONUTS page

[PMID:19416887-16] Li, Y et al. (2009) ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response. Proc. Natl. Acad. Sci. U.S.A. 106 7945-50 PubMed GONUTS page

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HUMAN:IFNB

Contents

Annotations

Notes

References

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