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HUMAN:HYAS3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) HAS3
Protein Name(s) Hyaluronan synthase 3

Hyaluronate synthase 3 Hyaluronic acid synthase 3 HA synthase 3

External Links
UniProt O00219
EMBL AF232772
AK291400
AC009027
CH471092
CH471092
BC021853
U86409
CCDS CCDS10870.1
CCDS10871.1
RefSeq NP_001186209.1
NP_005320.2
NP_619515.1
XP_005255977.1
XP_005255978.1
UniGene Hs.592069
ProteinModelPortal O00219
BioGrid 109288
STRING 9606.ENSP00000304440
CAZy GT2
PhosphoSite O00219
MaxQB O00219
PaxDb O00219
PRIDE O00219
Ensembl ENST00000219322
ENST00000306560
ENST00000569188
GeneID 3038
KEGG hsa:3038
UCSC uc002ewk.3
uc002ewl.3
CTD 3038
GeneCards GC16P069140
HGNC HGNC:4820
HPA CAB033850
HPA031554
MIM 602428
neXtProt NX_O00219
PharmGKB PA29196
eggNOG COG1215
GeneTree ENSGT00390000010337
HOGENOM HOG000112847
HOVERGEN HBG000189
InParanoid O00219
KO K00752
OMA RGRLWNI
OrthoDB EOG77WWBZ
PhylomeDB O00219
TreeFam TF332506
BRENDA 2.4.1.212
Reactome REACT_121301
UniPathway UPA00341
GeneWiki HAS3
GenomeRNAi 3038
NextBio 12028
PRO PR:O00219
Proteomes UP000005640
Bgee O00219
CleanEx HS_HAS3
ExpressionAtlas O00219
Genevestigator O00219
GO GO:0036117
GO:0016021
GO:0005887
GO:0005886
GO:0050501
GO:0005975
GO:0007155
GO:0085029
GO:0045226
GO:0030203
GO:0030213
GO:0030212
GO:0009405
GO:1900106
GO:0045893
GO:0044281
Gene3D 3.90.550.10
InterPro IPR026108
IPR026107
IPR029044
PANTHER PTHR22913
PTHR22913:SF6
SUPFAM SSF53448

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1900106

positive regulation of hyaluranon cable assembly

PMID:16900089[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0085029

extracellular matrix assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O08650

P

Seeded From UniProt

complete

enables

GO:0050501

hyaluronan synthase activity

PMID:16900089[1]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(CL:0002306)

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:16900089[1]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0002306)|has_regulation_target(UniProtKB:Q12794)|has_regulation_target(UniProtKB:Q12891)

Seeded From UniProt

complete

involved_in

GO:0045226

extracellular polysaccharide biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O08650

P

Seeded From UniProt

complete

part_of

GO:0036117

hyaluranon cable

PMID:16900089[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030213

hyaluronan biosynthetic process

PMID:16900089[1]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0002306)

Seeded From UniProt

complete

involved_in

GO:0085029

extracellular matrix assembly

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106590
MGI:MGI:107821
MGI:MGI:109599
PANTHER:PTN000530809

P

Seeded From UniProt

complete

enables

GO:0050501

hyaluronan synthase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106590
MGI:MGI:107821
MGI:MGI:109599
PANTHER:PTN000530809
RGD:2781
UniProtKB:O00219
UniProtKB:Q92819

F

Seeded From UniProt

complete

involved_in

GO:0045226

extracellular polysaccharide biosynthetic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106590
MGI:MGI:107821
MGI:MGI:109599
PANTHER:PTN000530809

P

Seeded From UniProt

complete

involved_in

GO:0030213

hyaluronan biosynthetic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106590
MGI:MGI:107821
MGI:MGI:109599
PANTHER:PTN000530809
RGD:2781
UniProtKB:O00219
UniProtKB:Q92819

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000530809
UniProtKB:Q92819

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25795779[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O00219

F

occurs_in:(GO:0005794)|occurs_in:(GO:0005886)

Seeded From UniProt

complete

involved_in

GO:0085029

extracellular matrix assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08650
ensembl:ENSMUSP00000034385

P

Seeded From UniProt

complete

enables

GO:0050501

hyaluronan synthase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08650
ensembl:ENSMUSP00000034385

F

Seeded From UniProt

complete

involved_in

GO:0045226

extracellular polysaccharide biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08650
ensembl:ENSMUSP00000034385

P

Seeded From UniProt

complete

involved_in

GO:0030213

hyaluronan biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08650
ensembl:ENSMUSP00000034385

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08650
ensembl:ENSMUSP00000034385

C

Seeded From UniProt

complete

involved_in

GO:0030213

hyaluronan biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026108

P

Seeded From UniProt

complete

enables

GO:0050501

hyaluronan synthase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026108

F

Seeded From UniProt

complete

enables

GO:0050501

hyaluronan synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.4.1.212

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:9083017[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

PMID:9169154[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:9169154[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030213

hyaluronan biosynthetic process

Reactome:R-HSA-2142850

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-2160851

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

enables

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0328

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0030213

hyaluronan biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00341

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Selbi, W et al. (2006) Characterization of hyaluronan cable structure and function in renal proximal tubular epithelial cells. Kidney Int. 70 1287-95 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ Bart, G et al. (2015) Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3. J. Biol. Chem. 290 11479-90 PubMed GONUTS page
  4. ↑ Spicer, AP et al. (1997) Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase. J. Biol. Chem. 272 8957-61 PubMed GONUTS page
  5. ↑ 5.0 5.1 Spicer, AP et al. (1997) Chromosomal localization of the human and mouse hyaluronan synthase genes. Genomics 41 493-7 PubMed GONUTS page
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