HUMAN:HXK2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HK2
Protein Name(s)	Hexokinase-2 Hexokinase type II HK II Muscle form hexokinase
External Links
UniProt	P52789
EMBL	Z46376 Z46354 Z46355 Z46604 Z46356 Z46357 Z46358 Z46359 Z46360 Z46361 Z46362 Z46363 Z46364 Z46365 Z46366 Z46367 Z46368 Z46369 AF148513 AY623118 CH471053 CH471053 BC021116 BC064369 D25412
CCDS	CCDS1956.1
PIR	S48809
RefSeq	NP_000180.2
UniGene	Hs.406266 Hs.591588
PDB	2NZT
PDBsum	2NZT
ProteinModelPortal	P52789
SMR	P52789
BioGrid	109346
DIP	DIP-50110N
IntAct	P52789
MINT	MINT-1461614
STRING	9606.ENSP00000290573
ChEMBL	CHEMBL2640
PhosphoSite	P52789
DMDM	56405344
MaxQB	P52789
PaxDb	P52789
PeptideAtlas	P52789
PRIDE	P52789
DNASU	3099
Ensembl	ENST00000290573
GeneID	3099
KEGG	hsa:3099
UCSC	uc002snd.3
CTD	3099
GeneCards	GC02P075059
H-InvDB	HIX0030207
HGNC	HGNC:4923
HPA	HPA028587
MIM	601125
neXtProt	NX_P52789
PharmGKB	PA29301
eggNOG	COG5026
GeneTree	ENSGT00390000017159
HOGENOM	HOG000162671
HOVERGEN	HBG005020
InParanoid	P52789
KO	K00844
OMA	HHLGLES
OrthoDB	EOG7S21X5
PhylomeDB	P52789
TreeFam	TF314238
BioCyc	MetaCyc:HS08399-MONOMER
Reactome	REACT_212
SABIO-RK	P52789
UniPathway	UPA00242
ChiTaRS	HK2
EvolutionaryTrace	P52789
GeneWiki	HK2
GenomeRNAi	3099
NextBio	12305
PRO	PR:P52789
Proteomes	UP000005640
Bgee	P52789
CleanEx	HS_HK2
ExpressionAtlas	P52789
Genevestigator	P52789
GO	GO:0005829 GO:0016020 GO:0005741 GO:0005524 GO:0008865 GO:0004340 GO:0005536 GO:0004396 GO:0019158 GO:0008637 GO:0005975 GO:0001678 GO:0051156 GO:0006006 GO:0015758 GO:0006096 GO:0008645 GO:0007595 GO:0046324 GO:0002931 GO:0044281 GO:0055085
InterPro	IPR001312 IPR022673 IPR019807 IPR022672
PANTHER	PTHR19443
Pfam	PF00349 PF03727
PRINTS	PR00475
PROSITE	PS00378

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016301	kinase activity	PMID:22691140^[1]	ECO:0000314			F		Figure 4 shows that "Knockdown of HK2 as well as miR-143 overexpression results in decreased lactate secretion. "	complete CACAO 5722
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:25801897^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0072656	maintenance of protein location in mitochondrion	PMID:23962723^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000540) has_input:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:1904925	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	PMID:23962723^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:0072655	establishment of protein localization to mitochondrion	PMID:23962723^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000540) has_input:(UniProtKB:O60260)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:7622509^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019158	mannokinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c	F		Seeded From UniProt	complete
enables	GO:0008865	fructokinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c TAIR:locus:2008031 TAIR:locus:2087590 TAIR:locus:2119931 TAIR:locus:2137564 TAIR:locus:2202410 UniProtKB:P93834 UniProtKB:Q4WHC3	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 RGD:2670 RGD:2796 SGD:S000000545 SGD:S000001949 SGD:S000003222	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 MGI:MGI:96103 PANTHER:PTN000455350 RGD:2670 RGD:2796 SGD:S000003222 UniProtKB:C6KT76 UniProtKB:P35557	C		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 MGI:MGI:96103 PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c RGD:2670 RGD:2796 SGD:S000000545 TAIR:locus:2008031 TAIR:locus:2087590 TAIR:locus:2119931 TAIR:locus:2137564 TAIR:locus:2202410 UniProtKB:P35557 UniProtKB:P93834 UniProtKB:Q4WCS2 UniProtKB:Q4WHC3 UniProtKB:Q5W676 UniProtKB:Q8LQ68	F		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 PANTHER:PTN000455350 RGD:2670	P		Seeded From UniProt	complete
involved_in	GO:0008637	apoptotic mitochondrial changes	PMID:18350175^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:18350175^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051156	glucose 6-phosphate metabolic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004340	P		Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08528 ensembl:ENSMUSP00000000642	P		Seeded From UniProt	complete
involved_in	GO:1990830	cellular response to leukemia inhibitory factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08528 ensembl:ENSMUSP00000000642	P		Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08528 ensembl:ENSMUSP00000000642	P		Seeded From UniProt	complete
involved_in	GO:0046324	regulation of glucose import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08528 ensembl:ENSMUSP00000000642	P		Seeded From UniProt	complete
involved_in	GO:0035795	negative regulation of mitochondrial membrane permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08528 ensembl:ENSMUSP00000000642	P		Seeded From UniProt	complete
involved_in	GO:0008637	apoptotic mitochondrial changes	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08528 ensembl:ENSMUSP00000000642	P		Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08528 ensembl:ENSMUSP00000000642	P		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08528 ensembl:ENSMUSP00000000642	F		Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	P		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	C		Seeded From UniProt	complete
involved_in	GO:0007595	lactation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	C		Seeded From UniProt	complete
enables	GO:0005536	glucose binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	F		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	F		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	P		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312	P		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR019807	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR019807 InterPro:IPR022672 InterPro:IPR022673	F		Seeded From UniProt	complete
enables	GO:0005536	glucose binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312	F		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR022672 InterPro:IPR022673	P		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019807	P		Seeded From UniProt	complete
enables	GO:0016773	phosphotransferase activity, alcohol group as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022672 InterPro:IPR022673	F		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.1	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:23962723^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	PMID:9278438^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061621	canonical glycolysis	Reactome:R-HSA-70171	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-70420	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0324	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0019318	hexose metabolic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00242	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gregersen, LH et al. (2012) MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells. BMC Cancer 12 232 PubMed GONUTS page
↑ Climent, M et al. (2015) TGFβ Triggers miR-143/145 Transfer From Smooth Muscle Cells to Endothelial Cells, Thereby Modulating Vessel Stabilization. Circ. Res. 116 1753-64 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 McCoy, MK et al. (2014) Hexokinase activity is required for recruitment of parkin to depolarized mitochondria. Hum. Mol. Genet. 23 145-56 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Mathupala, SP et al. (1995) Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase. J. Biol. Chem. 270 16918-25 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 Chiara, F et al. (2008) Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. PLoS ONE 3 e1852 PubMed GONUTS page
↑ Mathupala, SP et al. (1997) Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53. J. Biol. Chem. 272 22776-80 PubMed GONUTS page

[PMID:22691140-1] Gregersen, LH et al. (2012) MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells. BMC Cancer 12 232 PubMed GONUTS page

[PMID:25801897-2] Climent, M et al. (2015) TGFβ Triggers miR-143/145 Transfer From Smooth Muscle Cells to Endothelial Cells, Thereby Modulating Vessel Stabilization. Circ. Res. 116 1753-64 PubMed GONUTS page

[PMID:23962723-3] 3.0 ^3.1 ^3.2 ^3.3 McCoy, MK et al. (2014) Hexokinase activity is required for recruitment of parkin to depolarized mitochondria. Hum. Mol. Genet. 23 145-56 PubMed GONUTS page

[PMID:19946888-4] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:7622509-5] Mathupala, SP et al. (1995) Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase. J. Biol. Chem. 270 16918-25 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18350175-7] 7.0 ^7.1 Chiara, F et al. (2008) Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. PLoS ONE 3 e1852 PubMed GONUTS page

[PMID:9278438-8] Mathupala, SP et al. (1997) Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53. J. Biol. Chem. 272 22776-80 PubMed GONUTS page

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HUMAN:HXK2

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