HUMAN:HRG

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HRG
Protein Name(s)	Histidine-rich glycoprotein Histidine-proline-rich glycoprotein HPRG
External Links
UniProt	P04196
EMBL	M13149 AB005803 CH471052 CH471052 BC069574 BC150591 Z17218
CCDS	CCDS3280.1
PIR	A01287
RefSeq	NP_000403.1
UniGene	Hs.1498
ProteinModelPortal	P04196
SMR	P04196
BioGrid	109509
DIP	DIP-47264N
IntAct	P04196
STRING	9606.ENSP00000232003
MEROPS	I25.022
PhosphoSite	P04196
DMDM	123523
SWISS-2DPAGE	P04196
PaxDb	P04196
PeptideAtlas	P04196
PRIDE	P04196
Ensembl	ENST00000232003
GeneID	3273
KEGG	hsa:3273
UCSC	uc003fqq.3
CTD	3273
GeneCards	GC03P186378
HGNC	HGNC:5181
HPA	HPA050269 HPA054598
MIM	142640 613116
neXtProt	NX_P04196
Orphanet	217467
PharmGKB	PA29455
eggNOG	NOG75740
GeneTree	ENSGT00730000111384
HOGENOM	HOG000090255
HOVERGEN	HBG004597
InParanoid	P04196
OMA	ISKFFAY
OrthoDB	EOG7HXCSK
PhylomeDB	P04196
TreeFam	TF333729
Reactome	REACT_641
GeneWiki	HRG_(gene)
GenomeRNAi	3273
NextBio	12999
PRO	PR:P04196
Proteomes	UP000005640
Bgee	P04196
CleanEx	HS_HRG
Genevestigator	P04196
GO	GO:0072562 GO:0036019 GO:0005576 GO:0070062 GO:0061474 GO:0005886 GO:0031093 GO:0004869 GO:0020037 GO:0043395 GO:0008201 GO:0019865 GO:0046872 GO:0005102 GO:0004867 GO:0008270 GO:0001525 GO:0007596 GO:0006935 GO:0050832 GO:0042730 GO:0097037 GO:0016525 GO:0043537 GO:0007162 GO:0033629 GO:0030308 GO:0008285 GO:2001027 GO:0051918 GO:0010593 GO:1900747 GO:0030168 GO:0002576 GO:0043065 GO:2000504 GO:0051894 GO:0002839 GO:0032956 GO:0030193 GO:0010468 GO:0050730 GO:0010543 GO:0043254 GO:0034395 GO:0014070
InterPro	IPR000010
Pfam	PF00031
SMART	SM00043

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28344315^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002371)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28675934^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0003688)\|part_of:(UBERON:0001911)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001155)	Seeded From UniProt	complete
involved_in	GO:0051715	cytolysis in other organism	PMID:18797515^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051715	cytolysis in other organism	PMID:18797515^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051715	cytolysis in other organism	PMID:18797515^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051715	cytolysis in other organism	PMID:18797515^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050832	defense response to fungus	PMID:18797515^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050832	defense response to fungus	PMID:18797515^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050832	defense response to fungus	PMID:18797515^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:18797515^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:27068509^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0072562	blood microparticle	PMID:22516433^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:2001027	negative regulation of endothelial cell chemotaxis	PMID:14744774^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001027	negative regulation of endothelial cell chemotaxis	PMID:16436387^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001027	negative regulation of endothelial cell chemotaxis	PMID:16489009^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000504	positive regulation of blood vessel remodeling	PMID:21215706^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	PMID:16489009^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	PMID:14744774^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	PMID:16436387^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050832	defense response to fungus	PMID:18797515^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	PMID:16489009^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	PMID:678554^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043537	negative regulation of blood vessel endothelial cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ESB3	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:15220341^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0043395	heparan sulfate proteoglycan binding	PMID:16436387^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043395	heparan sulfate proteoglycan binding	PMID:15138272^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043254	regulation of protein complex assembly	PMID:16489009^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:14744774^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033629	negative regulation of cell adhesion mediated by integrin	PMID:16489009^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	PMID:16489009^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:21215706^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030193	regulation of blood coagulation	PMID:6740558^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030193	regulation of blood coagulation	PMID:21304106^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	PMID:19903770^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:678554^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019865	immunoglobulin binding	PMID:10514432^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:14744774^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:16436387^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:16489009^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:19903770^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010593	negative regulation of lamellipodium assembly	PMID:16489009^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010543	regulation of platelet activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ESB3	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21215706^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:14744774^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:16436387^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:15138272^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:21304106^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:16436387^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:21304106^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007162	negative regulation of cell adhesion	PMID:14744774^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:18797515^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:14718574^[20]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:16436387^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(GO:0009986) has_direct_input:(CHEBI:28815) occurs_in:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:0002839	positive regulation of immune response to tumor cell	PMID:21215706^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051918	negative regulation of fibrinolysis	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2146636 PANTHER:PTN001418583	P		Seeded From UniProt	complete
part_of	GO:0036019	endolysosome	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2146636 PANTHER:PTN001418583	C		Seeded From UniProt	complete
involved_in	GO:0015886	heme transport	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2146636 PANTHER:PTN001418583	P		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890221 PANTHER:PTN000352258	P		Seeded From UniProt	complete
involved_in	GO:0010543	regulation of platelet activation	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2146636 PANTHER:PTN001418583	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001418583 UniProtKB:P04196	F		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001418583 UniProtKB:P04196	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000352258 UniProtKB:P04196	C		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2146636 PANTHER:PTN001418583	F		Seeded From UniProt	complete
enables	GO:0004869	cysteine-type endopeptidase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000010	F		Seeded From UniProt	complete
involved_in	GO:0042730	fibrinolysis	Reactome:R-HSA-75205	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031093	platelet alpha granule lumen	Reactome:R-HSA-481007	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-158982 Reactome:R-HSA-158941 Reactome:R-HSA-158925	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-481007 Reactome:R-HSA-158722 Reactome:R-HSA-158721	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	Reactome:R-HSA-114608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042730	fibrinolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0280	P		Seeded From UniProt	complete
involved_in	GO:0007599	hemostasis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0356	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0094	P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page
↑ Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
↑ ^3.0 ^3.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Rydengård, V et al. (2008) Histidine-rich glycoprotein protects from systemic Candida infection. PLoS Pathog. 4 e1000116 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Olsson, AK et al. (2004) A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization. Cancer Res. 64 599-605 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Vanwildemeersch, M et al. (2006) The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner. J. Biol. Chem. 281 10298-304 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Dixelius, J et al. (2006) Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein. Cancer Res. 66 2089-97 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Rolny, C et al. (2011) HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. Cancer Cell 19 31-44 PubMed GONUTS page
↑ ^13.0 ^13.1 Morgan, WT (1978) Human serum histidine-rich glycoprotein. I. Interactions with heme, metal ions and organic ligands. Biochim. Biophys. Acta 535 319-33 PubMed GONUTS page
↑ Jones, AL et al. (2004) Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoprotein. J. Biol. Chem. 279 38267-76 PubMed GONUTS page
↑ ^15.0 ^15.1 Jones, AL et al. (2004) Histidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn2+ chelation. J. Biol. Chem. 279 30114-22 PubMed GONUTS page
↑ Lijnen, HR et al. (1984) Histidine-rich glycoprotein modulates the anticoagulant activity of heparin in human plasma. Thromb. Haemost. 51 266-8 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 MacQuarrie, JL et al. (2011) Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation. Blood 117 4134-41 PubMed GONUTS page
↑ ^18.0 ^18.1 Thulin, A et al. (2009) Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein. Mol. Cancer Res. 7 1792-802 PubMed GONUTS page
↑ Gorgani, NN et al. (1999) Differential binding of histidine-rich glycoprotein (HRG) to human IgG subclasses and IgG molecules containing kappa and lambda light chains. J. Biol. Chem. 274 29633-40 PubMed GONUTS page
↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 ^21.7 ^21.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:28344315-1] Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page

[PMID:28675934-2] Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page

[PMID:25037231-3] 3.0 ^3.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page

[PMID:18797515-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Rydengård, V et al. (2008) Histidine-rich glycoprotein protects from systemic Candida infection. PLoS Pathog. 4 e1000116 PubMed GONUTS page

[PMID:27068509-5] Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:23533145-6] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:22516433-7] Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page

[PMID:19056867-8] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:14744774-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Olsson, AK et al. (2004) A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization. Cancer Res. 64 599-605 PubMed GONUTS page

[PMID:16436387-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Vanwildemeersch, M et al. (2006) The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner. J. Biol. Chem. 281 10298-304 PubMed GONUTS page

[PMID:16489009-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Dixelius, J et al. (2006) Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein. Cancer Res. 66 2089-97 PubMed GONUTS page

[PMID:21215706-12] 12.0 ^12.1 ^12.2 ^12.3 Rolny, C et al. (2011) HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. Cancer Cell 19 31-44 PubMed GONUTS page

[PMID:678554-13] 13.0 ^13.1 Morgan, WT (1978) Human serum histidine-rich glycoprotein. I. Interactions with heme, metal ions and organic ligands. Biochim. Biophys. Acta 535 319-33 PubMed GONUTS page

[PMID:15220341-14] Jones, AL et al. (2004) Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoprotein. J. Biol. Chem. 279 38267-76 PubMed GONUTS page

[PMID:15138272-15] 15.0 ^15.1 Jones, AL et al. (2004) Histidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn2+ chelation. J. Biol. Chem. 279 30114-22 PubMed GONUTS page

[PMID:6740558-16] Lijnen, HR et al. (1984) Histidine-rich glycoprotein modulates the anticoagulant activity of heparin in human plasma. Thromb. Haemost. 51 266-8 PubMed GONUTS page

[PMID:21304106-17] 17.0 ^17.1 ^17.2 MacQuarrie, JL et al. (2011) Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation. Blood 117 4134-41 PubMed GONUTS page

[PMID:19903770-18] 18.0 ^18.1 Thulin, A et al. (2009) Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein. Mol. Cancer Res. 7 1792-802 PubMed GONUTS page

[PMID:10514432-19] Gorgani, NN et al. (1999) Differential binding of histidine-rich glycoprotein (HRG) to human IgG subclasses and IgG molecules containing kappa and lambda light chains. J. Biol. Chem. 274 29633-40 PubMed GONUTS page

[PMID:14718574-20] Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page

[PMID:21873635-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 ^21.7 ^21.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:HRG

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