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HUMAN:HNMT

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) HNMT
Protein Name(s) Histamine N-methyltransferase

HMT

External Links
UniProt P50135
EMBL D16224
U08092
U44111
U44106
U44107
U44108
U44109
U44110
AF523358
AF523359
AF523360
AF523356
AF523357
AK313804
AC093674
CH471058
CH471058
CH471058
BC005907
BC020677
AH012839
CCDS CCDS2181.1
CCDS33296.1
CCDS33297.1
PIR G01409
RefSeq NP_001019245.1
NP_001019246.1
NP_008826.1
UniGene Hs.42151
PDB 1ICZ
1JQD
1JQE
2AOT
2AOU
2AOV
2AOW
2AOX
PDBsum 1ICZ
1JQD
1JQE
2AOT
2AOU
2AOV
2AOW
2AOX
ProteinModelPortal P50135
SMR P50135
BioGrid 109418
IntAct P50135
MINT MINT-5001055
STRING 9606.ENSP00000280097
BindingDB P50135
ChEMBL CHEMBL2190
DrugBank DB00613
DB00878
DB00667
DB01103
PhosphoSite P50135
DMDM 1708272
MaxQB P50135
PaxDb P50135
PeptideAtlas P50135
PRIDE P50135
DNASU 3176
Ensembl ENST00000280096
ENST00000280097
ENST00000329366
ENST00000410115
ENST00000475675
GeneID 3176
KEGG hsa:3176
UCSC uc002tvd.3
uc002tve.3
uc002tvf.3
CTD 3176
GeneCards GC02P138744
HGNC HGNC:5028
HPA HPA035481
MIM 605238
neXtProt NX_P50135
PharmGKB PA190
eggNOG NOG39680
GeneTree ENSGT00390000002862
HOGENOM HOG000231790
HOVERGEN HBG051914
InParanoid P50135
KO K00546
OMA MDISDCF
OrthoDB EOG7Z69CQ
PhylomeDB P50135
TreeFam TF331080
BioCyc MetaCyc:HS07674-MONOMER
EvolutionaryTrace P50135
GenomeRNAi 3176
NextBio 12602
PRO PR:P50135
Proteomes UP000005640
Bgee P50135
CleanEx HS_HNMT
Genevestigator P50135
GO GO:0005737
GO:0070062
GO:0043005
GO:0005634
GO:0046539
GO:0007420
GO:0006972
GO:0007585
GO:0014075
GO:0042220
GO:0051384
GO:0035902
GO:0070555
GO:0002347
Gene3D 3.40.50.150
InterPro IPR016673
IPR029063
PIRSF PIRSF016616
SUPFAM SSF53335
PROSITE PS51597

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005737

cytoplasm

PMID:26206890[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0001695

histamine catabolic process

PMID:26206890[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

PMID:26206890[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046539

histamine N-methyltransferase activity

PMID:26206890[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0046539

histamine N-methyltransferase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001445566
RGD:71049
UniProtKB:A0A1D5NTU3
UniProtKB:P50135

F

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000424037
RGD:71049

C

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001445566
UniProtKB:P50135

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000424037
RGD:71049

P

Seeded From UniProt

complete

involved_in

GO:0070555

response to interleukin-1

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01984
ensembl:ENSRNOP00000007471

P

Seeded From UniProt

complete

involved_in

GO:0051384

response to glucocorticoid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01984
ensembl:ENSRNOP00000007471

P

Seeded From UniProt

complete

enables

GO:0046539

histamine N-methyltransferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01984
ensembl:ENSRNOP00000007471

F

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01984
ensembl:ENSRNOP00000007471

C

Seeded From UniProt

complete

involved_in

GO:0042220

response to cocaine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01984
ensembl:ENSRNOP00000007471

P

Seeded From UniProt

complete

involved_in

GO:0035902

response to immobilization stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01984
ensembl:ENSRNOP00000007471

P

Seeded From UniProt

complete

involved_in

GO:0014075

response to amine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01984
ensembl:ENSRNOP00000007471

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01984
ensembl:ENSRNOP00000007471

P

Seeded From UniProt

complete

involved_in

GO:0006972

hyperosmotic response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01984
ensembl:ENSRNOP00000007471

P

Seeded From UniProt

complete

involved_in

GO:0002347

response to tumor cell

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01984
ensembl:ENSRNOP00000007471

P

Seeded From UniProt

complete

enables

GO:0008170

N-methyltransferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91VF2
ensembl:ENSMUSP00000062747

F

Seeded From UniProt

complete

enables

GO:0008170

N-methyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016673

F

Seeded From UniProt

complete

enables

GO:0046539

histamine N-methyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.1.8

F

Seeded From UniProt

complete

involved_in

GO:0007585

respiratory gaseous exchange

PMID:7943261[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046539

histamine N-methyltransferase activity

Reactome:R-HSA-175993

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006548

histidine catabolic process

Reactome:R-HSA-70921

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-175993

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Heidari, A et al. (2015) Mutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability. Hum. Mol. Genet. 24 5697-710 PubMed GONUTS page
  2. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Yamauchi, K et al. (1994) Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway. Am. J. Physiol. 267 L342-9 PubMed GONUTS page
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