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HUMAN:HMGC2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | HMGCLL1 | |
| Protein Name(s) | 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1 Endoplasmic reticulum 3-hydroxymethyl-3-methylglutaryl-CoA lyase er-cHL | |
| External Links | ||
| UniProt | Q8TB92 | |
| EMBL | AK055075 AK127587 AK293856 AL590290 AL590406 CH471081 CH471081 BC024194 | |
| CCDS | CCDS43474.1 CCDS43475.1 CCDS75473.1 | |
| RefSeq | NP_001035865.1 NP_001274670.1 NP_001274675.1 NP_061909.2 | |
| UniGene | Hs.147054 | |
| ProteinModelPortal | Q8TB92 | |
| SMR | Q8TB92 | |
| STRING | 9606.ENSP00000381654 | |
| PhosphoSite | Q8TB92 | |
| DMDM | 189028466 | |
| PaxDb | Q8TB92 | |
| PRIDE | Q8TB92 | |
| DNASU | 54511 | |
| Ensembl | ENST00000274901 ENST00000308161 ENST00000370852 ENST00000398661 | |
| GeneID | 54511 | |
| KEGG | hsa:54511 | |
| UCSC | uc003pcn.3 uc003pco.3 uc011dxc.2 | |
| CTD | 54511 | |
| GeneCards | GC06M055299 | |
| HGNC | HGNC:21359 | |
| HPA | HPA030223 | |
| neXtProt | NX_Q8TB92 | |
| PharmGKB | PA134989971 | |
| eggNOG | COG0119 | |
| GeneTree | ENSGT00390000017690 | |
| HOGENOM | HOG000219757 | |
| HOVERGEN | HBG064656 | |
| InParanoid | Q8TB92 | |
| OMA | GHSRANV | |
| PhylomeDB | Q8TB92 | |
| TreeFam | TF105363 | |
| UniPathway | UPA00896 | |
| ChiTaRS | HMGCLL1 | |
| GenomeRNAi | 54511 | |
| NextBio | 56890 | |
| PRO | PR:Q8TB92 | |
| Proteomes | UP000005640 | |
| Bgee | Q8TB92 | |
| CleanEx | HS_HMGCLL1 | |
| ExpressionAtlas | Q8TB92 | |
| Genevestigator | Q8TB92 | |
| GO | GO:0005829 GO:0005783 GO:0005789 GO:0016020 GO:0048471 GO:0004419 GO:0046872 GO:0046951 | |
| Gene3D | 3.20.20.70 | |
| InterPro | IPR013785 IPR030021 IPR000891 | |
| PANTHER | PTHR10277:SF33 | |
| Pfam | PF00682 | |
| PROSITE | PS50991 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046951 |
ketone body biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046951 |
ketone body biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004419 |
hydroxymethylglutaryl-CoA lyase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004419 |
hydroxymethylglutaryl-CoA lyase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004419 |
hydroxymethylglutaryl-CoA lyase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046951 |
ketone body biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000031222 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000031222 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006552 |
leucine catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000031222 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000814676 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000814676 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004419 |
hydroxymethylglutaryl-CoA lyase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000031222 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004419 |
hydroxymethylglutaryl-CoA lyase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046951 |
ketone body biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004419 |
hydroxymethylglutaryl-CoA lyase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046951 |
ketone body biosynthetic process |
Reactome:R-HSA-77111 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-6788597 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016829 |
lyase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Montgomery, C et al. (2012) Identification and characterization of an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase. J. Biol. Chem. 287 33227-36 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Arnedo, M et al. (2012) Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol. J. Lipid Res. 53 2046-56 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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