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HUMAN:HEXA
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | HEXA | |
| Protein Name(s) | Beta-hexosaminidase subunit alpha
Beta-N-acetylhexosaminidase subunit alpha Hexosaminidase subunit A N-acetyl-beta-glucosaminidase subunit alpha | |
| External Links | ||
| UniProt | P06865 | |
| EMBL | M16424 M16411 M16412 M16413 M16414 M16415 M16416 M16417 M16418 M16419 M16420 M16421 M16422 M16423 S62076 S62047 S62049 S62051 S62053 S62055 S62057 S62059 S62061 S62063 S62066 S62068 S62070 S62072 AK296528 AK222502 CR627386 AC009690 BC018927 BC084537 M13520 | |
| CCDS | CCDS10243.1 | |
| PIR | A23561 | |
| RefSeq | NP_000511.2 | |
| UniGene | Hs.604479 Hs.709495 | |
| PDB | 1QBC 2GJX 2GK1 | |
| PDBsum | 1QBC 2GJX 2GK1 | |
| ProteinModelPortal | P06865 | |
| SMR | P06865 | |
| BioGrid | 109322 | |
| IntAct | P06865 | |
| MINT | MINT-1393072 | |
| STRING | 9606.ENSP00000268097 | |
| BindingDB | P06865 | |
| ChEMBL | CHEMBL3038485 | |
| CAZy | GH20 | |
| PhosphoSite | P06865 | |
| DMDM | 311033393 | |
| MaxQB | P06865 | |
| PaxDb | P06865 | |
| PeptideAtlas | P06865 | |
| PRIDE | P06865 | |
| DNASU | 3073 | |
| Ensembl | ENST00000268097 | |
| GeneID | 3073 | |
| KEGG | hsa:3073 | |
| UCSC | uc002aun.4 | |
| CTD | 3073 | |
| GeneCards | GC15M072635 | |
| GeneReviews | HEXA | |
| H-InvDB | HIX0012407 | |
| HGNC | HGNC:4878 | |
| HPA | HPA054583 | |
| MIM | 272800 606869 | |
| neXtProt | NX_P06865 | |
| Orphanet | 309192 309178 309185 309239 | |
| PharmGKB | PA29256 | |
| eggNOG | COG3525 | |
| GeneTree | ENSGT00390000008107 | |
| HOGENOM | HOG000157972 | |
| HOVERGEN | HBG005961 | |
| InParanoid | P06865 | |
| KO | K12373 | |
| OrthoDB | EOG7KDFB6 | |
| PhylomeDB | P06865 | |
| TreeFam | TF313036 | |
| BioCyc | MetaCyc:ENSG00000140495-MONOMER | |
| Reactome | REACT_116105 REACT_120888 REACT_120996 REACT_121313 | |
| SABIO-RK | P06865 | |
| EvolutionaryTrace | P06865 | |
| GeneWiki | HEXA | |
| GenomeRNAi | 3073 | |
| NextBio | 12155 | |
| PRO | PR:P06865 | |
| Proteomes | UP000005640 | |
| Bgee | P06865 | |
| CleanEx | HS_HEXA | |
| ExpressionAtlas | P06865 | |
| Genevestigator | P06865 | |
| GO | GO:0070062 GO:0043202 GO:0016020 GO:0004563 GO:0046982 GO:0005975 GO:0030207 GO:0030204 GO:0030203 GO:0006687 GO:0030214 GO:0030212 GO:0042340 GO:0042339 GO:0044281 GO:0006665 | |
| Gene3D | 3.20.20.80 3.30.379.10 | |
| InterPro | IPR025705 IPR029018 IPR015883 IPR013781 IPR017853 IPR029019 | |
| Pfam | PF00728 PF14845 | |
| PIRSF | PIRSF001093 | |
| PRINTS | PR00738 | |
| SUPFAM | SSF51445 SSF55545 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0003824 |
catalytic activity |
ECO:0000315 |
F |
Figure 1: chromatogram of mutations |
complete | |||||
|
enables |
GO:0008375 |
acetylglucosaminyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042582 |
azurophil granule |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000775) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006024 |
glycosaminoglycan biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004553 |
hydrolase activity, hydrolyzing O-glycosyl compounds |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004563 |
beta-N-acetylhexosaminidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005975 |
carbohydrate metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0102148 |
N-acetyl-beta-D-galactosaminidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004563 |
beta-N-acetylhexosaminidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043202 |
lysosomal lumen |
Reactome:R-HSA-2162225 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0042340 |
keratan sulfate catabolic process |
Reactome:R-HSA-2022857 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030214 |
hyaluronan catabolic process |
Reactome:R-HSA-2160916 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030207 |
chondroitin sulfate catabolic process |
Reactome:R-HSA-2024101 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006687 |
glycosphingolipid metabolic process |
Reactome:R-HSA-1660662 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016798 |
hydrolase activity, acting on glycosyl bonds |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Navashin, SM & Sazykin, IuO (1988) [Molecular bases of modern antibiotic therapy]. Antibiot. Khimioter. 33 3-12 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Thaysen-Andersen, M et al. (2015) Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum. J. Biol. Chem. 290 8789-802 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ Proia, RL et al. (1984) Association of alpha- and beta-subunits during the biosynthesis of beta-hexosaminidase in cultured human fibroblasts. J. Biol. Chem. 259 3350-4 PubMed GONUTS page
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