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HUMAN:HEM4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) UROS
Protein Name(s) Uroporphyrinogen-III synthase

UROIIIS UROS Hydroxymethylbilane hydrolyase [cyclizing] Uroporphyrinogen-III cosynthase

External Links
UniProt P10746
EMBL J03824
AF230665
AH010036
AK314896
AL360176
CH471066
CH471066
BC002573
CCDS CCDS7648.1
PIR A40483
RefSeq NP_000366.1
UniGene Hs.501376
PDB 1JR2
PDBsum 1JR2
ProteinModelPortal P10746
SMR P10746
BioGrid 113236
IntAct P10746
MINT MINT-2863993
STRING 9606.ENSP00000357775
ChEMBL CHEMBL4433
PhosphoSite P10746
BioMuta UROS
DMDM 122849
MaxQB P10746
PaxDb P10746
PRIDE P10746
DNASU 7390
Ensembl ENST00000368786
ENST00000368797
GeneID 7390
KEGG hsa:7390
UCSC uc001liw.4
CTD 7390
GeneCards GC10M127467
GeneReviews UROS
HGNC HGNC:12592
HPA HPA044038
MIM 263700
606938
neXtProt NX_P10746
Orphanet 79277
PharmGKB PA37222
eggNOG COG1587
GeneTree ENSGT00390000009853
HOGENOM HOG000007209
HOVERGEN HBG000492
InParanoid P10746
KO K01719
OMA ALQPHGC
OrthoDB EOG7K3TMH
PhylomeDB P10746
TreeFam TF324092
BioCyc MetaCyc:HS07569-MONOMER
BRENDA 4.2.1.75
Reactome REACT_9465
UniPathway UPA00251
EvolutionaryTrace P10746
GenomeRNAi 7390
NextBio 28934
PRO PR:P10746
Proteomes UP000005640
Bgee P10746
CleanEx HS_UROS
ExpressionAtlas P10746
Genevisible P10746
GO GO:0005829
GO:0005739
GO:0048037
GO:0004852
GO:0071418
GO:0071243
GO:0006783
GO:0006778
GO:0006782
GO:0046677
GO:0044281
GO:0006780
InterPro IPR003754
Pfam PF02602
SUPFAM SSF69618

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006780

uroporphyrinogen III biosynthetic process

ECO:0000304

P

Source: ProtInc

Missing: reference

involved_in

GO:0006783

heme biosynthetic process

PMID:3805019[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006783

heme biosynthetic process

PMID:18004775[2]

ECO:0000305

curator inference used in manual assertion

GO:0004852

P

Seeded From UniProt

complete

involved_in

GO:0006780

uroporphyrinogen III biosynthetic process

PMID:18004775[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006780

uroporphyrinogen III biosynthetic process

PMID:3805019[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006780

uroporphyrinogen III biosynthetic process

PMID:3174619[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:3805019[1]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P51163

C

Seeded From UniProt

complete

enables

GO:0004852

uroporphyrinogen-III synthase activity

PMID:18004775[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004852

uroporphyrinogen-III synthase activity

PMID:3805019[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004852

uroporphyrinogen-III synthase activity

PMID:3174619[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006783

heme biosynthetic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000273374
SGD:S000005804
UniProtKB:P10746

P

Seeded From UniProt

complete

involved_in

GO:0006780

uroporphyrinogen III biosynthetic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000273374
RGD:1310396
UniProtKB:P10746

P

Seeded From UniProt

complete

enables

GO:0004852

uroporphyrinogen-III synthase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98917
PANTHER:PTN000273374
RGD:1310396
SGD:S000005804
UniProtKB:P10746

F

Seeded From UniProt

complete

involved_in

GO:0006779

porphyrin-containing compound biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51163
ensembl:ENSMUSP00000033276

P

Seeded From UniProt

complete

enables

GO:0004852

uroporphyrinogen-III synthase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51163
ensembl:ENSMUSP00000033276

F

Seeded From UniProt

complete

involved_in

GO:0071418

cellular response to amine stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XIF2
ensembl:ENSRNOP00000024278

P

Seeded From UniProt

complete

involved_in

GO:0071243

cellular response to arsenic-containing substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XIF2
ensembl:ENSRNOP00000024278

P

Seeded From UniProt

complete

involved_in

GO:0070541

response to platinum ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XIF2
ensembl:ENSRNOP00000024278

P

Seeded From UniProt

complete

enables

GO:0048037

cofactor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XIF2
ensembl:ENSRNOP00000024278

F

Seeded From UniProt

complete

involved_in

GO:0046677

response to antibiotic

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XIF2
ensembl:ENSRNOP00000024278

P

Seeded From UniProt

complete

involved_in

GO:0006780

uroporphyrinogen III biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XIF2
ensembl:ENSRNOP00000024278

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XIF2
ensembl:ENSRNOP00000024278

C

Seeded From UniProt

complete

enables

GO:0004852

uroporphyrinogen-III synthase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XIF2
ensembl:ENSRNOP00000024278

F

Seeded From UniProt

complete

enables

GO:0004852

uroporphyrinogen-III synthase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003754
InterPro:IPR036108
InterPro:IPR039793

F

Seeded From UniProt

complete

involved_in

GO:0006780

uroporphyrinogen III biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039793

P

Seeded From UniProt

complete

involved_in

GO:0033014

tetrapyrrole biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003754
InterPro:IPR036108

P

Seeded From UniProt

complete

enables

GO:0004852

uroporphyrinogen-III synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:4.2.1.75

F

Seeded From UniProt

complete

involved_in

GO:0006783

heme biosynthetic process

Reactome:R-HSA-189451

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-189488

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004852

uroporphyrinogen-III synthase activity

Reactome:R-HSA-189488

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006779

porphyrin-containing compound biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0627

P

Seeded From UniProt

complete

involved_in

GO:0006783

heme biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0350

P

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

involved_in

GO:0006782

protoporphyrinogen IX biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00251

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Tsai, SF et al. (1987) Purification and properties of uroporphyrinogen III synthase from human erythrocytes. J. Biol. Chem. 262 1268-73 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Cunha, L et al. (2008) Human uroporphyrinogen III synthase: NMR-based mapping of the active site. Proteins 71 855-73 PubMed GONUTS page
  3. ↑ 3.0 3.1 Tsai, SF et al. (1988) Human uroporphyrinogen III synthase: molecular cloning, nucleotide sequence, and expression of a full-length cDNA. Proc. Natl. Acad. Sci. U.S.A. 85 7049-53 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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