HUMAN:HAS2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HAS2
Protein Name(s)	Hyaluronan synthase 2 Hyaluronate synthase 2 Hyaluronic acid synthase 2 HA synthase 2
External Links
UniProt	Q92819
EMBL	U54804 BC069353 BC109071 BC109072
IPI	IPI00023713
RefSeq	NP_005319.1
UniGene	Hs.159226
ProteinModelPortal	Q92819
STRING	9606.ENSP00000306991
CAZy	GT2
PhosphoSite	Q92819
DMDM	7387737
PaxDb	Q92819
PRIDE	Q92819
Ensembl	ENST00000303924
GeneID	3037
KEGG	hsa:3037
UCSC	uc003yph.2
CTD	3037
GeneCards	GC08M122624
HGNC	HGNC:4819
MIM	601636
neXtProt	NX_Q92819
PharmGKB	PA29195
eggNOG	COG1215
HOGENOM	HOG000112847
HOVERGEN	HBG000189
InParanoid	Q92819
KO	K00752
OMA	TAYIMGY
OrthoDB	EOG4KH2TP
PhylomeDB	Q92819
BRENDA	2.4.1.212
Reactome	REACT_111217 REACT_116125
UniPathway	UPA00341
ChiTaRS	HAS2
GeneWiki	HAS2
GenomeRNAi	3037
NextBio	12022
PRO	PR:Q92819
Bgee	Q92819
CleanEx	HS_HAS2
Genevestigator	Q92819
GO	GO:0005887 GO:0050501 GO:0060349 GO:0071498 GO:0071347 GO:0036120 GO:0071356 GO:0030213 GO:0001822 GO:0030335 GO:0008284 GO:1900625 GO:0035810 GO:0070295
InterPro	IPR004835 IPR026107
PANTHER	PTHR22913
Pfam	PF03142

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1900625	positive regulation of monocyte aggregation	PMID:20522558^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071498	cellular response to fluid shear stress	PMID:21551265^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	PMID:20522558^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	PMID:20522558^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	PMID:22016393^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:22016393^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	PMID:22016393^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:22016393^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:20522558^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090500	endocardial cushion to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70312	P		Seeded From UniProt	complete
involved_in	GO:0085029	extracellular matrix assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70312	P		Seeded From UniProt	complete
involved_in	GO:0070295	renal water absorption	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35776	P		Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35776	F		Seeded From UniProt	complete
involved_in	GO:0045226	extracellular polysaccharide biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70312	P		Seeded From UniProt	complete
involved_in	GO:0036302	atrioventricular canal development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70312	P		Seeded From UniProt	complete
involved_in	GO:0036120	cellular response to platelet-derived growth factor stimulus	PMID:17324121^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002620)	Seeded From UniProt	complete
involved_in	GO:0035810	positive regulation of urine volume	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35776	P		Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	PMID:17324121^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35776	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35776	P		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70312	P		Seeded From UniProt	complete
involved_in	GO:0085029	extracellular matrix assembly	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106590 MGI:MGI:107821 MGI:MGI:109599 PANTHER:PTN000530809	P		Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106590 MGI:MGI:107821 MGI:MGI:109599 PANTHER:PTN000530809 RGD:2781 UniProtKB:O00219 UniProtKB:Q92819	F		Seeded From UniProt	complete
involved_in	GO:0045226	extracellular polysaccharide biosynthetic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106590 MGI:MGI:107821 MGI:MGI:109599 PANTHER:PTN000530809	P		Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106590 MGI:MGI:107821 MGI:MGI:109599 PANTHER:PTN000530809 RGD:2781 UniProtKB:O00219 UniProtKB:Q92819	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000530809 UniProtKB:Q92819	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25795779^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92819	F	occurs_in:(GO:0005794)\|occurs_in:(GO:0005886)	Seeded From UniProt	complete
involved_in	GO:1901201	regulation of extracellular matrix assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:1900127	positive regulation of hyaluronan biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:0070295	renal water absorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:0051549	positive regulation of keratinocyte migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	F		Seeded From UniProt	complete
involved_in	GO:0044849	estrous cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:0035810	positive regulation of urine volume	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:0014911	positive regulation of smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:0010838	positive regulation of keratinocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:0090500	endocardial cushion to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70312 ensembl:ENSMUSP00000062212	P		Seeded From UniProt	complete
involved_in	GO:0085029	extracellular matrix assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70312 ensembl:ENSMUSP00000062212	P		Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70312 ensembl:ENSMUSP00000062212	P		Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70312 ensembl:ENSMUSP00000062212	F		Seeded From UniProt	complete
involved_in	GO:0045226	extracellular polysaccharide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70312 ensembl:ENSMUSP00000062212	P		Seeded From UniProt	complete
part_of	GO:0044853	plasma membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70312 ensembl:ENSMUSP00000062212	C		Seeded From UniProt	complete
involved_in	GO:0036302	atrioventricular canal development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70312 ensembl:ENSMUSP00000062212	P		Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70312 ensembl:ENSMUSP00000062212	P		Seeded From UniProt	complete
involved_in	GO:0030212	hyaluronan metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70312 ensembl:ENSMUSP00000062212	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70312 ensembl:ENSMUSP00000062212	C		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70312 ensembl:ENSMUSP00000062212	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028371	C		Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028371	P		Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028371	F		Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.4.1.212	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0016757	transferase activity, transferring glycosyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0328	F		Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00341	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Vigetti, D et al. (2010) Proinflammatory cytokines induce hyaluronan synthesis and monocyte adhesion in human endothelial cells through hyaluronan synthase 2 (HAS2) and the nuclear factor-kappaB (NF-kappaB) pathway. J. Biol. Chem. 285 24639-45 PubMed GONUTS page
↑ Maroski, J et al. (2011) Shear stress increases endothelial hyaluronan synthase 2 and hyaluronan synthesis especially in regard to an atheroprotective flow profile. Exp. Physiol. 96 977-86 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Bernert, B et al. (2011) Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1). J. Biol. Chem. 286 42349-59 PubMed GONUTS page
↑ ^4.0 ^4.1 Li, L et al. (2007) Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB. Biochem. J. 404 327-36 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Bart, G et al. (2015) Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3. J. Biol. Chem. 290 11479-90 PubMed GONUTS page

[PMID:20522558-1] 1.0 ^1.1 ^1.2 ^1.3 Vigetti, D et al. (2010) Proinflammatory cytokines induce hyaluronan synthesis and monocyte adhesion in human endothelial cells through hyaluronan synthase 2 (HAS2) and the nuclear factor-kappaB (NF-kappaB) pathway. J. Biol. Chem. 285 24639-45 PubMed GONUTS page

[PMID:21551265-2] Maroski, J et al. (2011) Shear stress increases endothelial hyaluronan synthase 2 and hyaluronan synthesis especially in regard to an atheroprotective flow profile. Exp. Physiol. 96 977-86 PubMed GONUTS page

[PMID:22016393-3] 3.0 ^3.1 ^3.2 ^3.3 Bernert, B et al. (2011) Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1). J. Biol. Chem. 286 42349-59 PubMed GONUTS page

[PMID:17324121-4] 4.0 ^4.1 Li, L et al. (2007) Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB. Biochem. J. 404 327-36 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25795779-6] Bart, G et al. (2015) Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3. J. Biol. Chem. 290 11479-90 PubMed GONUTS page

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HUMAN:HAS2

Contents

Annotations

Notes

References

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