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HUMAN:GSTO2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | GSTO2 | |
| Protein Name(s) | Glutathione S-transferase omega-2
GSTO-2 Glutathione S-transferase omega 2-2 GSTO 2-2 Glutathione-dependent dehydroascorbate reductase Monomethylarsonic acid reductase MMA(V) reductase | |
| External Links | ||
| UniProt | Q9H4Y5 | |
| EMBL | AY350731 AY209189 AK291886 AK296266 AL139341 AL162742 AL162742 CH471066 BC046194 BC056918 AY191318 | |
| CCDS | CCDS53574.1 CCDS53575.1 CCDS7556.1 | |
| RefSeq | NP_001177942.1 NP_001177943.1 NP_001177944.1 NP_899062.1 XP_006717686.1 | |
| UniGene | Hs.107384 Hs.203634 | |
| PDB | 3Q18 3Q19 3QAG | |
| PDBsum | 3Q18 3Q19 3QAG | |
| ProteinModelPortal | Q9H4Y5 | |
| SMR | Q9H4Y5 | |
| BioGrid | 125638 | |
| STRING | 9606.ENSP00000345023 | |
| ChEMBL | CHEMBL2161 | |
| DrugBank | DB00143 | |
| PhosphoSite | Q9H4Y5 | |
| DMDM | 34922124 | |
| PaxDb | Q9H4Y5 | |
| PRIDE | Q9H4Y5 | |
| DNASU | 119391 | |
| Ensembl | ENST00000338595 ENST00000369707 ENST00000450629 | |
| GeneID | 119391 | |
| KEGG | hsa:119391 | |
| UCSC | uc001kyb.3 uc010qqx.2 | |
| CTD | 119391 | |
| GeneCards | GC10P106018 | |
| HGNC | HGNC:23064 | |
| HPA | HPA048141 | |
| MIM | 612314 | |
| neXtProt | NX_Q9H4Y5 | |
| PharmGKB | PA133787053 | |
| eggNOG | COG0625 | |
| GeneTree | ENSGT00390000005479 | |
| HOGENOM | HOG000006560 | |
| HOVERGEN | HBG051853 | |
| InParanoid | Q9H4Y5 | |
| KO | K00799 | |
| OMA | VYGIADC | |
| OrthoDB | EOG71CFNG | |
| PhylomeDB | Q9H4Y5 | |
| TreeFam | TF105325 | |
| BRENDA | 2.5.1.18 | |
| Reactome | REACT_11202 REACT_6926 | |
| ChiTaRS | GSTO2 | |
| GeneWiki | GSTO2 | |
| GenomeRNAi | 119391 | |
| NextBio | 80409 | |
| PRO | PR:Q9H4Y5 | |
| Proteomes | UP000005640 | |
| Bgee | Q9H4Y5 | |
| CleanEx | HS_GSTO2 | |
| Genevestigator | Q9H4Y5 | |
| GO | GO:0005829 GO:0070062 GO:0045174 GO:0004364 GO:0050610 GO:0016491 GO:0071243 GO:1901687 GO:0019852 GO:0055114 GO:0044281 GO:0006766 GO:0006767 GO:0006805 | |
| Gene3D | 1.20.1050.10 3.40.30.10 | |
| InterPro | IPR010987 IPR004045 IPR005442 IPR012336 | |
| Pfam | PF13417 | |
| PRINTS | PR01625 | |
| SUPFAM | SSF47616 SSF52833 | |
| PROSITE | PS50405 PS50404 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071243 |
cellular response to arsenic-containing substance |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0045174 |
glutathione dehydrogenase (ascorbate) activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019852 |
L-ascorbic acid metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006805 |
xenobiotic metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000883725 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0045174 |
glutathione dehydrogenase (ascorbate) activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0035904 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0098869 |
cellular oxidant detoxification |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0045174 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0098869 |
cellular oxidant detoxification |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0045174 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0098869 |
cellular oxidant detoxification |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0045174 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004364 |
glutathione transferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004364 |
glutathione transferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050610 |
methylarsonate reductase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0045174 |
glutathione dehydrogenase (ascorbate) activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901687 |
glutathione derivative biosynthetic process |
Reactome:R-HSA-156590 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019852 |
L-ascorbic acid metabolic process |
Reactome:R-HSA-196836 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-198813 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Schmuck, EM et al. (2005) Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases. Pharmacogenet. Genomics 15 493-501 PubMed GONUTS page
- ↑ 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
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