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HUMAN:GSTO2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) GSTO2
Protein Name(s) Glutathione S-transferase omega-2

GSTO-2 Glutathione S-transferase omega 2-2 GSTO 2-2 Glutathione-dependent dehydroascorbate reductase Monomethylarsonic acid reductase MMA(V) reductase

External Links
UniProt Q9H4Y5
EMBL AY350731
AY209189
AK291886
AK296266
AL139341
AL162742
AL162742
CH471066
BC046194
BC056918
AY191318
CCDS CCDS53574.1
CCDS53575.1
CCDS7556.1
RefSeq NP_001177942.1
NP_001177943.1
NP_001177944.1
NP_899062.1
XP_006717686.1
UniGene Hs.107384
Hs.203634
PDB 3Q18
3Q19
3QAG
PDBsum 3Q18
3Q19
3QAG
ProteinModelPortal Q9H4Y5
SMR Q9H4Y5
BioGrid 125638
STRING 9606.ENSP00000345023
ChEMBL CHEMBL2161
DrugBank DB00143
PhosphoSite Q9H4Y5
DMDM 34922124
PaxDb Q9H4Y5
PRIDE Q9H4Y5
DNASU 119391
Ensembl ENST00000338595
ENST00000369707
ENST00000450629
GeneID 119391
KEGG hsa:119391
UCSC uc001kyb.3
uc010qqx.2
CTD 119391
GeneCards GC10P106018
HGNC HGNC:23064
HPA HPA048141
MIM 612314
neXtProt NX_Q9H4Y5
PharmGKB PA133787053
eggNOG COG0625
GeneTree ENSGT00390000005479
HOGENOM HOG000006560
HOVERGEN HBG051853
InParanoid Q9H4Y5
KO K00799
OMA VYGIADC
OrthoDB EOG71CFNG
PhylomeDB Q9H4Y5
TreeFam TF105325
BRENDA 2.5.1.18
Reactome REACT_11202
REACT_6926
ChiTaRS GSTO2
GeneWiki GSTO2
GenomeRNAi 119391
NextBio 80409
PRO PR:Q9H4Y5
Proteomes UP000005640
Bgee Q9H4Y5
CleanEx HS_GSTO2
Genevestigator Q9H4Y5
GO GO:0005829
GO:0070062
GO:0045174
GO:0004364
GO:0050610
GO:0016491
GO:0071243
GO:1901687
GO:0019852
GO:0055114
GO:0044281
GO:0006766
GO:0006767
GO:0006805
Gene3D 1.20.1050.10
3.40.30.10
InterPro IPR010987
IPR004045
IPR005442
IPR012336
Pfam PF13417
PRINTS PR01625
SUPFAM SSF47616
SSF52833
PROSITE PS50405
PS50404

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070062

extracellular exosome

PMID:19056867[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0071243

cellular response to arsenic-containing substance

PMID:15970797[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

PMID:15970797[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0045174

glutathione dehydrogenase (ascorbate) activity

PMID:15970797[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0019852

L-ascorbic acid metabolic process

PMID:15970797[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

PMID:15970797[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006805

xenobiotic metabolic process

PMID:15970797[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000883725
UniProtKB:Q9H4Y5
WB:WBGene00016204

P

Seeded From UniProt

complete

enables

GO:0045174

glutathione dehydrogenase (ascorbate) activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0035904
FB:FBgn0035906
FB:FBgn0035907
FB:FBgn0086348
PANTHER:PTN000883725
RGD:70952
UniProtKB:P78417
UniProtKB:Q9H4Y5
WB:WBGene00016204

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25416956[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9H4Y5

F

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0045174

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0045174

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0045174

P

Seeded From UniProt

complete

enables

GO:0004364

glutathione transferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005442

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005442

C

Seeded From UniProt

complete

enables

GO:0004364

glutathione transferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.5.1.18

F

Seeded From UniProt

complete

enables

GO:0050610

methylarsonate reductase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.20.4.2

F

Seeded From UniProt

complete

enables

GO:0045174

glutathione dehydrogenase (ascorbate) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.8.5.1

F

Seeded From UniProt

complete

involved_in

GO:1901687

glutathione derivative biosynthetic process

Reactome:R-HSA-156590

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019852

L-ascorbic acid metabolic process

Reactome:R-HSA-196836

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-198813
Reactome:R-HSA-176054

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Schmuck, EM et al. (2005) Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases. Pharmacogenet. Genomics 15 493-501 PubMed GONUTS page
  3. 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page