HUMAN:GRM2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	GRM2 (synonyms: GPRC1B, MGLUR2)
Protein Name(s)	Metabotropic glutamate receptor 2 mGluR2
External Links
UniProt	Q14416
EMBL	L35318 AB045011 AY999299 EU432122 CH471055 BC113615 BC113619
CCDS	CCDS2834.1
RefSeq	NP_000830.2 NP_001123535.1 XP_006713184.1
UniGene	Hs.121510
ProteinModelPortal	Q14416
SMR	Q14416
DIP	DIP-59826N
STRING	9606.ENSP00000378492
BindingDB	Q14416
ChEMBL	CHEMBL5137
GuidetoPHARMACOLOGY	290
PhosphoSite	Q14416
DMDM	76803802
PaxDb	Q14416
PRIDE	Q14416
DNASU	2912
Ensembl	ENST00000395052
GeneID	2912
KEGG	hsa:2912
UCSC	uc010hlv.3
CTD	2912
GeneCards	GC03P051716
HGNC	HGNC:4594
MIM	604099
neXtProt	NX_Q14416
PharmGKB	PA28991
eggNOG	NOG295200
GeneTree	ENSGT00760000118884
HOGENOM	HOG000218635
HOVERGEN	HBG107965
InParanoid	Q14416
KO	K04605
OMA	TSQVVIC
OrthoDB	EOG7Z0JXG
PhylomeDB	Q14416
TreeFam	TF313240
Reactome	REACT_18319 REACT_19231
GeneWiki	Metabotropic_glutamate_receptor_2
GenomeRNAi	2912
NextBio	11543
PRO	PR:Q14416
Proteomes	UP000005640
Bgee	Q14416
CleanEx	HS_GRM2
ExpressionAtlas	Q14416
Genevestigator	Q14416
GO	GO:0030424 GO:0030054 GO:0030425 GO:0005887 GO:0005622 GO:0005886 GO:0042734 GO:0005246 GO:0004930 GO:0008066 GO:0001641 GO:0007196 GO:0014047 GO:0007194 GO:0051966 GO:0007268
InterPro	IPR001828 IPR000337 IPR011500 IPR017978 IPR017979 IPR000162 IPR001458 IPR028082
Pfam	PF00003 PF01094 PF07562
PRINTS	PR00248 PR01052 PR00593
SUPFAM	SSF53822
PROSITE	PS00979 PS00980 PS00981 PS50259

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0051966	regulation of synaptic transmission, glutamatergic	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019985 PANTHER:PTN001173581 RGD:2742	P	Seeded From UniProt	complete
enables	GO:0008066	glutamate receptor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001173581 RGD:2746 UniProtKB:O00222 UniProtKB:O15303 UniProtKB:P41594 UniProtKB:Q13255 UniProtKB:Q14831 UniProtKB:Q14833	F	Seeded From UniProt	complete
enables	GO:0008066	glutamate receptor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001173581 RGD:2746 UniProtKB:A0A0B4KF15 UniProtKB:O00222 UniProtKB:O15303 UniProtKB:P41594 UniProtKB:Q13255 UniProtKB:Q14831 UniProtKB:Q14833	F	Seeded From UniProt	complete
involved_in	GO:0007216	G protein-coupled glutamate receptor signaling pathway	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019985 PANTHER:PTN001173581 RGD:2742 RGD:2746 UniProtKB:O15303 UniProtKB:P41594 UniProtKB:Q13255	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000206 FB:FBgn0019985 PANTHER:PTN001173583 RGD:619858 UniProtKB:A0A0B4KF15 UniProtKB:O15303 UniProtKB:P41594 UniProtKB:Q13255 UniProtKB:Q14833	C	Seeded From UniProt	complete
enables	GO:0005246	calcium channel regulator activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1351339 PANTHER:PTN001173698	F	Seeded From UniProt	complete
involved_in	GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0001641	P	Seeded From UniProt	complete
involved_in	GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0001641	P	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31421 ensembl:ENSRNOP00000017607	C	Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31421 ensembl:ENSRNOP00000017607	C	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31421 ensembl:ENSRNOP00000017607	C	Seeded From UniProt	complete
involved_in	GO:0014047	glutamate secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31421 ensembl:ENSRNOP00000017607	P	Seeded From UniProt	complete
enables	GO:0001641	group II metabotropic glutamate receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31421 ensembl:ENSRNOP00000017607	F	Seeded From UniProt	complete
involved_in	GO:0090461	glutamate homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14BI2 ensembl:ENSMUSP00000023959	P	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14BI2 ensembl:ENSMUSP00000023959	C	Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14BI2 ensembl:ENSMUSP00000023959	P	Seeded From UniProt	complete
enables	GO:0005246	calcium channel regulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14BI2 ensembl:ENSMUSP00000023959	F	Seeded From UniProt	complete
enables	GO:0001641	group II metabotropic glutamate receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14BI2 ensembl:ENSMUSP00000023959	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000337 InterPro:IPR011500 InterPro:IPR017978 InterPro:IPR017979	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000162 InterPro:IPR000337 InterPro:IPR001458 InterPro:IPR011500 InterPro:IPR017978 InterPro:IPR017979	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000162 InterPro:IPR000337 InterPro:IPR001458 InterPro:IPR017978 InterPro:IPR017979	C	Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:7620613^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007194	negative regulation of adenylate cyclase activity	PMID:7620613^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:7620613^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0008066	glutamate receptor activity	PMID:7620613^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:7620613^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-380073 Reactome:R-HSA-373075	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Flor, PJ et al. (1995) Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2. Eur. J. Neurosci. 7 622-9 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7620613-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Flor, PJ et al. (1995) Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2. Eur. J. Neurosci. 7 622-9 PubMed GONUTS page

[1]

[2]

HUMAN:GRM2

Contents

Annotations

Notes

References

a

c

d

e

g

h

i

m

n

o

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools