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HUMAN:GRK6
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | GRK6 (synonyms: GPRK6) | |
| Protein Name(s) | G protein-coupled receptor kinase 6
G protein-coupled receptor kinase GRK6 | |
| External Links | ||
| UniProt | P43250 | |
| EMBL | L16862 AF040751 AF040752 AC145098 BC009277 U00686 | |
| CCDS | CCDS34303.1 CCDS43406.1 CCDS47348.1 | |
| PIR | A48765 | |
| RefSeq | NP_001004105.1 NP_001004106.1 NP_002073.2 | |
| UniGene | Hs.235116 | |
| PDB | 2ACX 3NYN 3NYO | |
| PDBsum | 2ACX 3NYN 3NYO | |
| ProteinModelPortal | P43250 | |
| SMR | P43250 | |
| BioGrid | 109128 | |
| IntAct | P43250 | |
| MINT | MINT-1425525 | |
| STRING | 9606.ENSP00000377204 | |
| BindingDB | P43250 | |
| ChEMBL | CHEMBL6144 | |
| GuidetoPHARMACOLOGY | 1470 | |
| PhosphoSite | P43250 | |
| DMDM | 20141386 | |
| MaxQB | P43250 | |
| PaxDb | P43250 | |
| PRIDE | P43250 | |
| DNASU | 2870 | |
| Ensembl | ENST00000355472 ENST00000355958 ENST00000528793 | |
| GeneID | 2870 | |
| KEGG | hsa:2870 | |
| UCSC | uc003mgq.2 uc021yit.1 uc021yiu.1 | |
| CTD | 2870 | |
| GeneCards | GC05P176853 | |
| HGNC | HGNC:4545 | |
| HPA | HPA015327 HPA018903 | |
| MIM | 600869 | |
| neXtProt | NX_P43250 | |
| PharmGKB | PA28942 | |
| eggNOG | COG0515 | |
| GeneTree | ENSGT00770000120493 | |
| HOGENOM | HOG000006742 | |
| HOVERGEN | HBG004532 | |
| InParanoid | P43250 | |
| KO | K08291 | |
| OMA | MLEPPFK | |
| OrthoDB | EOG7V1FQK | |
| PhylomeDB | P43250 | |
| TreeFam | TF313940 | |
| BRENDA | 2.7.11.16 | |
| SignaLink | P43250 | |
| EvolutionaryTrace | P43250 | |
| GeneWiki | GRK6 | |
| GenomeRNAi | 2870 | |
| NextBio | 11323 | |
| PRO | PR:P43250 | |
| Proteomes | UP000005640 | |
| Bgee | P43250 | |
| CleanEx | HS_GRK6 | |
| ExpressionAtlas | P43250 | |
| Genevestigator | P43250 | |
| GO | GO:0016020 GO:0005524 GO:0004703 GO:0008277 GO:0038032 GO:0016055 | |
| InterPro | IPR000961 IPR000239 IPR011009 IPR000719 IPR017441 IPR016137 IPR002290 IPR008271 | |
| Pfam | PF00069 PF00615 | |
| PRINTS | PR00717 | |
| SMART | SM00315 SM00133 SM00220 | |
| SUPFAM | SSF48097 SSF56112 | |
| PROSITE | PS51285 PS00107 PS50011 PS00108 PS50132 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0047696 |
beta-adrenergic receptor kinase activity |
ECO:0000314 |
F |
Fig. 3 |
complete | |||||
| GO:0047696 |
beta-adrenergic receptor kinase activity |
ECO:0000315 |
F |
Figure 7 |
complete | |||||
|
enables |
GO:0047696 |
beta-adrenergic receptor kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047696 |
beta-adrenergic receptor kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004703 |
G protein-coupled receptor kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000239 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000239 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004703 |
G protein-coupled receptor kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008277 |
regulation of G protein-coupled receptor signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047696 |
beta-adrenergic receptor kinase activity |
Reactome:R-HSA-8851797 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
Reactome:R-HSA-388396 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-8982645 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Baameur, F et al. (2010) Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation. Mol. Pharmacol. 77 405-15 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ Loudon, RP & Benovic, JL (1994) Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6. J. Biol. Chem. 269 22691-7 PubMed GONUTS page
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