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HUMAN:GRDN
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CCDC88A | |
| Protein Name(s) | Girdin
Akt phosphorylation enhancer APE Coiled-coil domain-containing protein 88A G alpha-interacting vesicle-associated protein GIV Girders of actin filament Hook-related protein 1 HkRP1 | |
| External Links | ||
| UniProt | Q3V6T2 | |
| EMBL | AB201172 AB125644 AC019198 AC092176 AC012358 BC132736 BC144320 BX537985 BX538154 BX648138 | |
| CCDS | CCDS33203.1 CCDS46288.1 CCDS58710.1 | |
| RefSeq | NP_001129069.1 NP_001241872.1 NP_060554.3 XP_005264480.1 | |
| UniGene | Hs.292925 | |
| ProteinModelPortal | Q3V6T2 | |
| SMR | Q3V6T2 | |
| BioGrid | 120829 | |
| IntAct | Q3V6T2 | |
| STRING | 9606.ENSP00000338728 | |
| PhosphoSite | Q3V6T2 | |
| DMDM | 147644956 | |
| MaxQB | Q3V6T2 | |
| PaxDb | Q3V6T2 | |
| PRIDE | Q3V6T2 | |
| Ensembl | ENST00000263630 ENST00000336838 ENST00000413716 ENST00000436346 | |
| GeneID | 55704 | |
| KEGG | hsa:55704 | |
| UCSC | uc002ryu.2 uc002ryv.2 uc010yoz.1 uc010ypa.1 | |
| CTD | 55704 | |
| GeneCards | GC02M055514 | |
| HGNC | HGNC:25523 | |
| HPA | HPA038101 | |
| MIM | 609736 | |
| neXtProt | NX_Q3V6T2 | |
| PharmGKB | PA162381751 | |
| eggNOG | NOG12793 | |
| GeneTree | ENSGT00690000101702 | |
| HOVERGEN | HBG057867 | |
| InParanoid | Q3V6T2 | |
| OMA | FEDVSPQ | |
| OrthoDB | EOG7N0C3V | |
| PhylomeDB | Q3V6T2 | |
| TreeFam | TF320231 | |
| ChiTaRS | CCDC88A | |
| GeneWiki | CCDC88A | |
| GenomeRNAi | 55704 | |
| NextBio | 60553 | |
| PRO | PR:Q3V6T2 | |
| Proteomes | UP000005640 | |
| Bgee | Q3V6T2 | |
| CleanEx | HS_CCDC88A | |
| ExpressionAtlas | Q3V6T2 | |
| Genevestigator | Q3V6T2 | |
| GO | GO:0016023 GO:0031410 GO:0005829 GO:0005783 GO:0005794 GO:0030027 GO:0016020 GO:0005886 GO:0003779 GO:0008017 GO:0035091 GO:0042803 GO:0043422 GO:0032148 GO:0016477 GO:0006260 GO:0030032 GO:0061024 GO:0032956 GO:0042127 GO:0006275 GO:0010975 GO:0001932 GO:0031929 | |
| InterPro | IPR027717 IPR008636 | |
| PANTHER | PTHR18947 PTHR18947:SF30 | |
| Pfam | PF05622 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0045724 |
positive regulation of cilium assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1903566 |
positive regulation of protein localization to cilium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0036064 |
ciliary basal body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005814 |
centriole |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061024 |
membrane organization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043422 |
protein kinase B binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042127 |
regulation of cell population proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0035091 |
phosphatidylinositol binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032956 |
regulation of actin cytoskeleton organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032148 |
activation of protein kinase B activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031929 |
TOR signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030032 |
lamellipodium assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016477 |
cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010975 |
regulation of neuron projection development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008017 |
microtubule binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006275 |
regulation of DNA replication |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0051496 |
positive regulation of stress fiber assembly |
ECO:0000315 |
P |
Figure 4B and 5C |
complete | |||||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003779 |
actin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001932 |
regulation of protein phosphorylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051959 |
dynein light intermediate chain binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000436622 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031122 |
cytoplasmic microtubule organization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000436622 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030705 |
cytoskeleton-dependent intracellular transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0001202 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008017 |
microtubule binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0001202 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005813 |
centrosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2443554 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0283724 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031682 |
G-protein gamma-subunit binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZYD7 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030142 |
COPI-coated Golgi to ER transport vesicle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZYD7 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043422 |
protein kinase B binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SNZ0 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042127 |
regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SNZ0 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032148 |
activation of protein kinase B activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SNZ0 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031929 |
TOR signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SNZ0 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031252 |
cell leading edge |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SNZ0 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010975 |
regulation of neuron projection development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SNZ0 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008017 |
microtubule binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SNZ0 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006275 |
regulation of DNA replication |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SNZ0 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001932 |
regulation of protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5SNZ0 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003779 |
actin binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016477 |
cell migration |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032956 |
regulation of actin cytoskeleton organization |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006260 |
DNA replication |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030030 |
cell projection organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005814 |
centriole |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Nechipurenko, IV et al. (2016) A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis. Dev. Cell 38 493-506 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Simpson, F et al. (2005) A novel hook-related protein family and the characterization of hook-related protein 1. Traffic 6 442-58 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Enomoto, A et al. (2005) Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev. Cell 9 389-402 PubMed GONUTS page
- ↑ 4.0 4.1 Le-Niculescu, H et al. (2005) Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles. J. Biol. Chem. 280 22012-20 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
- Catarrhini
- GO:0031252 ! cell leading edge
- GO:0016477 ! cell migration
- GO:0042995 ! cell projection
- GO:0030030 ! cell projection organization
- GO:0005814 ! centriole
- GO:0005813 ! centrosome
- Chordata
- GO:0036064 ! ciliary basal body
- GO:0030142 ! COPI-coated Golgi to ER transport vesicle
- Craniata
- GO:0005737 ! cytoplasm
- GO:0031410 ! cytoplasmic vesicle
- GO:0031122 ! cytoplasmic microtubule organization
- GO:0005856 ! cytoskeleton
- GO:0030705 ! cytoskeleton-dependent intracellular transport
- GO:0005829 ! cytosol
m
p
- GO:0035091 ! phosphatidylinositol binding
- GO:0005886 ! plasma membrane
- GO:1903566 ! positive regulation of protein localization to cilium
- GO:0051496 ! positive regulation of stress fiber assembly
- GO:0045724 ! positive regulation of cilium assembly
- Primates
- GO:0042803 ! protein homodimerization activity
- GO:0043422 ! protein kinase B binding
r
