HUMAN:GPR37

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	GPR37
Protein Name(s)	Prosaposin receptor GPR37 Endothelin B receptor-like protein 1 ETBR-LP-1 G-protein coupled receptor 37 Parkin-associated endothelin receptor-like receptor PAELR
External Links
UniProt	O15354
EMBL	Y12476 Y12477 AF017262 U87460 AF502281 AC004925 CH236947 CH471070 BC040007
CCDS	CCDS5792.1
PIR	JC5501
RefSeq	NP_005293.1
UniGene	Hs.406094 Hs.731392
ProteinModelPortal	O15354
SMR	O15354
BioGrid	109119
DIP	DIP-60954N
STRING	9606.ENSP00000306449
GuidetoPHARMACOLOGY	103
PhosphoSite	O15354
PaxDb	O15354
PRIDE	O15354
DNASU	2861
Ensembl	ENST00000303921
GeneID	2861
KEGG	hsa:2861
UCSC	uc003vli.4
CTD	2861
GeneCards	GC07M124386
HGNC	HGNC:4494
MIM	602583
neXtProt	NX_O15354
PharmGKB	PA28882
eggNOG	NOG291459
GeneTree	ENSGT00760000119177
HOGENOM	HOG000252922
HOVERGEN	HBG051808
InParanoid	O15354
KO	K04243
OMA	IQRRSRD
OrthoDB	EOG79SDX9
PhylomeDB	O15354
TreeFam	TF331292
Reactome	REACT_14819
GeneWiki	GPR37
GenomeRNAi	2861
NextBio	11281
PRO	PR:O15354
Proteomes	UP000005640
Bgee	O15354
CleanEx	HS_GPR37
Genevestigator	O15354
GO	GO:0005789 GO:0005887 GO:0005886 GO:0043235 GO:0000151 GO:0008528 GO:0004930 GO:0031072 GO:0030544 GO:0042277 GO:0031625 GO:0007193 GO:0042416 GO:0007186 GO:0031987 GO:1903206 GO:0045964 GO:0043410
InterPro	IPR000276 IPR017452 IPR003909
Pfam	PF00001
PRINTS	PR00237 PR01421
PROSITE	PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0008528	G protein-coupled peptide receptor activity	PMID:23690594^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:P07602:PRO_0000031622)	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:17059562^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q86TM6	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:17059562^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11439185^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:11439185^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60260	F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	PMID:23690594^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QY42	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:23690594^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	PMID:23690594^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:12150907^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12150907^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	PMID:12150907^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	PMID:12150907^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P31689	F		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	PMID:12150907^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11142	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:12150907^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UNE7	F		Seeded From UniProt	complete
enables	GO:0036505	prosaposin receptor activity	PMID:23690594^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:P07602)	Seeded From UniProt	complete
enables	GO:0042277	peptide binding	PMID:23690594^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q61207	F	has_input:(UniProtKB:P07602:PRO_0000031622)	Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:23382219^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QY42 ensembl:ENSMUSP00000052185	P		Seeded From UniProt	complete
involved_in	GO:0045964	positive regulation of dopamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QY42 ensembl:ENSMUSP00000052185	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QY42 ensembl:ENSMUSP00000052185	P		Seeded From UniProt	complete
involved_in	GO:0042416	dopamine biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QY42 ensembl:ENSMUSP00000052185	P		Seeded From UniProt	complete
involved_in	GO:0031987	locomotion involved in locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QY42 ensembl:ENSMUSP00000052185	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR003909	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR003909 InterPro:IPR017452	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:9144577^[6] Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9144577^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:9144577^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-5336182 Reactome:R-HSA-380073	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Meyer, RC et al. (2013) GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc. Natl. Acad. Sci. U.S.A. 110 9529-34 PubMed GONUTS page
↑ ^2.0 ^2.1 Omura, T et al. (2006) A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin. J. Neurochem. 99 1456-69 PubMed GONUTS page
↑ ^3.0 ^3.1 Imai, Y et al. (2001) An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell 105 891-902 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Imai, Y et al. (2002) CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol. Cell 10 55-67 PubMed GONUTS page
↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Zeng, Z et al. (1997) A novel endothelin receptor type-B-like gene enriched in the brain. Biochem. Biophys. Res. Commun. 233 559-67 PubMed GONUTS page

[PMID:23690594-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Meyer, RC et al. (2013) GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc. Natl. Acad. Sci. U.S.A. 110 9529-34 PubMed GONUTS page

[PMID:17059562-2] 2.0 ^2.1 Omura, T et al. (2006) A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin. J. Neurochem. 99 1456-69 PubMed GONUTS page

[PMID:11439185-3] 3.0 ^3.1 Imai, Y et al. (2001) An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell 105 891-902 PubMed GONUTS page

[PMID:12150907-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Imai, Y et al. (2002) CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol. Cell 10 55-67 PubMed GONUTS page

[PMID:23382219-5] Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page

[PMID:9144577-6] 6.0 ^6.1 ^6.2 Zeng, Z et al. (1997) A novel endothelin receptor type-B-like gene enriched in the brain. Biochem. Biophys. Res. Commun. 233 559-67 PubMed GONUTS page

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HUMAN:GPR37

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