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HUMAN:GPI8
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PIGK (synonyms: GPI8) | |
| Protein Name(s) | GPI-anchor transamidase
GPI transamidase GPI8 homolog hGPI8 Phosphatidylinositol-glycan biosynthesis class K protein PIG-K | |
| External Links | ||
| UniProt | Q92643 | |
| EMBL | Y07596 AF022913 AK304340 AK313015 AL035409 AC093433 AC113935 CH471059 BC020737 | |
| CCDS | CCDS674.1 | |
| RefSeq | NP_005473.1 | |
| UniGene | Hs.178305 | |
| ProteinModelPortal | Q92643 | |
| SMR | Q92643 | |
| BioGrid | 115343 | |
| IntAct | Q92643 | |
| MINT | MINT-2813159 | |
| STRING | 9606.ENSP00000359848 | |
| MEROPS | C13.005 | |
| PhosphoSite | Q92643 | |
| DMDM | 22001630 | |
| MaxQB | Q92643 | |
| PaxDb | Q92643 | |
| PRIDE | Q92643 | |
| DNASU | 10026 | |
| Ensembl | ENST00000370812 | |
| GeneID | 10026 | |
| KEGG | hsa:10026 | |
| UCSC | uc001dhk.3 | |
| CTD | 10026 | |
| GeneCards | GC01M077554 | |
| HGNC | HGNC:8965 | |
| HPA | HPA056383 HPA057040 | |
| MIM | 605087 | |
| neXtProt | NX_Q92643 | |
| PharmGKB | PA33296 | |
| eggNOG | COG5206 | |
| GeneTree | ENSGT00530000063391 | |
| HOGENOM | HOG000204398 | |
| HOVERGEN | HBG027488 | |
| InParanoid | Q92643 | |
| KO | K05290 | |
| OMA | MACNHRN | |
| OrthoDB | EOG70W3DZ | |
| PhylomeDB | Q92643 | |
| TreeFam | TF300848 | |
| Reactome | REACT_1830 | |
| UniPathway | UPA00196 | |
| ChiTaRS | PIGK | |
| GeneWiki | PIGK | |
| GenomeRNAi | 10026 | |
| NextBio | 35477318 | |
| PRO | PR:Q92643 | |
| Proteomes | UP000005640 | |
| Bgee | Q92643 | |
| CleanEx | HS_PIGK | |
| ExpressionAtlas | Q92643 | |
| Genevestigator | Q92643 | |
| GO | GO:0005789 GO:0042765 GO:0030176 GO:0016020 GO:0004197 GO:0003923 GO:0003756 GO:0016255 GO:0006501 GO:0044267 GO:0043687 GO:0006457 | |
| InterPro | IPR028361 IPR001096 | |
| PANTHER | PTHR12000 | |
| Pfam | PF01650 | |
| PIRSF | PIRSF500138 PIRSF019663 | |
| PRINTS | PR00776 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0042765 |
GPI-anchor transamidase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042765 |
GPI-anchor transamidase complex |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030176 |
integral component of endoplasmic reticulum membrane |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003923 |
GPI-anchor transamidase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042765 |
GPI-anchor transamidase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000243120 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034394 |
protein localization to cell surface |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000243120 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016255 |
attachment of GPI anchor to protein |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000243120 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003923 |
GPI-anchor transamidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000243120 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003923 |
GPI-anchor transamidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016255 |
attachment of GPI anchor to protein |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042765 |
GPI-anchor transamidase complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0034235 |
GPI anchor binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016255 |
attachment of GPI anchor to protein |
PMID:11483512[1] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
|
enables |
GO:0003756 |
protein disulfide isomerase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
Reactome:R-HSA-162836 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003923 |
GPI-anchor transamidase activity |
Reactome:R-HSA-162836 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006506 |
GPI anchor biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0337 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008234 |
cysteine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Ohishi, K et al. (2001) PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8. EMBO J. 20 4088-98 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Ohishi, K et al. (2000) Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins. Mol. Biol. Cell 11 1523-33 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Ohishi, K et al. (2003) Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge. J. Biol. Chem. 278 13959-67 PubMed GONUTS page
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