HUMAN:GP143

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	GPR143 (synonyms: OA1)
Protein Name(s)	G-protein coupled receptor 143 Ocular albinism type 1 protein
External Links
UniProt	P51810
EMBL	Z48804 AC003036 AC090481 CH471074 BC068977
CCDS	CCDS14134.2
RefSeq	NP_000264.2
UniGene	Hs.74124
ProteinModelPortal	P51810
BioGrid	110989
DIP	DIP-53284N
IntAct	P51810
STRING	9606.ENSP00000370316
GuidetoPHARMACOLOGY	203
PhosphoSite	P51810
DMDM	3219999
PaxDb	P51810
PRIDE	P51810
DNASU	4935
Ensembl	ENST00000467482
GeneID	4935
KEGG	hsa:4935
UCSC	uc004cst.2
CTD	4935
GeneCards	GC0XM009654
GeneReviews	GPR143
HGNC	HGNC:20145
HPA	HPA003648
MIM	300500 300808 300814
neXtProt	NX_P51810
Orphanet	651 54
PharmGKB	PA31872
eggNOG	NOG39873
GeneTree	ENSGT00390000016722
HOGENOM	HOG000112769
HOVERGEN	HBG051784
InParanoid	P51810
KO	K08470
OrthoDB	EOG7HXCQZ
PhylomeDB	P51810
TreeFam	TF324849
ChiTaRS	GPR143
GeneWiki	GPR143
GenomeRNAi	4935
NextBio	19011
PRO	PR:P51810
Proteomes	UP000005640
Bgee	P51810
CleanEx	HS_GPR143
ExpressionAtlas	P51810
Genevestigator	P51810
GO	GO:0016324 GO:0005737 GO:0005794 GO:0016021 GO:0005765 GO:0042470 GO:0033162 GO:0016020 GO:0005886 GO:0035240 GO:0004930 GO:0072544 GO:0035643 GO:0072545 GO:0035584 GO:0006726 GO:0007186 GO:0032400 GO:0032438 GO:0032402 GO:0007218 GO:0048015 GO:0050848 GO:0007165 GO:0007601
InterPro	IPR001414
Pfam	PF02101
PRINTS	PR00965

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0072545	tyrosine binding	PMID:18828673^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0072544	L-DOPA binding	PMID:18828673^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0050848	regulation of calcium-mediated signaling	PMID:18828673^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	PMID:16524428^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0042470	melanosome	PMID:10471510^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0035643	L-DOPA receptor activity	PMID:18828673^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0035584	calcium-mediated signaling using intracellular calcium source	PMID:18828673^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0035240	dopamine binding	PMID:18828673^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0033162	melanosome membrane	PMID:16621890^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032438	melanosome organization	PMID:19717472^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032402	melanosome transport	PMID:19717472^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032400	melanosome localization	PMID:19717472^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:18828673^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:18828673^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:16524428^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16524428^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:19717472^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	PMID:16621890^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:16524428^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0035643	L-DOPA receptor activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001032342 UniProtKB:P51810	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001032342 UniProtKB:P51810	P	Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035643	P	Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035643	P	Seeded From UniProt	complete
involved_in	GO:1903056	regulation of melanosome organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70259 ensembl:ENSMUSP00000026383	P	Seeded From UniProt	complete
involved_in	GO:1902908	regulation of melanosome transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70259 ensembl:ENSMUSP00000026383	P	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001414	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001414	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001414	C	Seeded From UniProt	complete
enables	GO:0035240	dopamine binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001414	F	Seeded From UniProt	complete
enables	GO:0072544	L-DOPA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001414	F	Seeded From UniProt	complete
enables	GO:0072545	tyrosine binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001414	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:7647783^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:10471510^[3] PMID:7647783^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	PMID:7647783^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10471510^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006726	eye pigment biosynthetic process	PMID:7647783^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10471510^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:10471510^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8851298 Reactome:R-HSA-749452 Reactome:R-HSA-749448 Reactome:R-HSA-379048	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0033162	melanosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0160	C	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C	Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0157	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Lopez, VM et al. (2008) L-DOPA is an endogenous ligand for OA1. PLoS Biol. 6 e236 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Innamorati, G et al. (2006) The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor. Pigment Cell Res. 19 125-35 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Schiaffino, MV et al. (1999) Ocular albinism: evidence for a defect in an intracellular signal transduction system. Nat. Genet. 23 108-12 PubMed GONUTS page
↑ ^4.0 ^4.1 Piccirillo, R et al. (2006) An unconventional dileucine-based motif and a novel cytosolic motif are required for the lysosomal and melanosomal targeting of OA1. J. Cell. Sci. 119 2003-14 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Giordano, F et al. (2009) The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition. Hum. Mol. Genet. 18 4530-45 PubMed GONUTS page
↑ ^6.0 ^6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Bassi, MT et al. (1995) Cloning of the gene for ocular albinism type 1 from the distal short arm of the X chromosome. Nat. Genet. 10 13-9 PubMed GONUTS page

[PMID:18828673-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Lopez, VM et al. (2008) L-DOPA is an endogenous ligand for OA1. PLoS Biol. 6 e236 PubMed GONUTS page

[PMID:16524428-2] 2.0 ^2.1 ^2.2 ^2.3 Innamorati, G et al. (2006) The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor. Pigment Cell Res. 19 125-35 PubMed GONUTS page

[PMID:10471510-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Schiaffino, MV et al. (1999) Ocular albinism: evidence for a defect in an intracellular signal transduction system. Nat. Genet. 23 108-12 PubMed GONUTS page

[PMID:16621890-4] 4.0 ^4.1 Piccirillo, R et al. (2006) An unconventional dileucine-based motif and a novel cytosolic motif are required for the lysosomal and melanosomal targeting of OA1. J. Cell. Sci. 119 2003-14 PubMed GONUTS page

[PMID:19717472-5] 5.0 ^5.1 ^5.2 ^5.3 Giordano, F et al. (2009) The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition. Hum. Mol. Genet. 18 4530-45 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7647783-7] 7.0 ^7.1 ^7.2 ^7.3 Bassi, MT et al. (1995) Cloning of the gene for ocular albinism type 1 from the distal short arm of the X chromosome. Nat. Genet. 10 13-9 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

HUMAN:GP143

Contents

Annotations

Notes

References

a

c

d

e

g

h

i

l

m

n

o

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools