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HUMAN:GNRHR

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) GNRHR (synonyms: GRHR)
Protein Name(s) Gonadotropin-releasing hormone receptor

GnRH receptor GnRH-R

External Links
UniProt P30968
EMBL L03380
L07949
S60587
S77472
AF001952
AF001950
AF001951
Z81148
AY392011
BC113546
Z99995
CCDS CCDS3517.1
CCDS47064.1
PIR JC1353
RefSeq NP_000397.1
NP_001012781.1
UniGene Hs.407587
ProteinModelPortal P30968
SMR P30968
BioGrid 109060
STRING 9606.ENSP00000226413
BindingDB P30968
ChEMBL CHEMBL1855
DrugBank DB00106
DB06719
DB00050
DB01406
DB06699
DB00644
DB00014
DB00007
DB00666
GuidetoPHARMACOLOGY 256
TCDB 9.A.14.10.1
DMDM 399777
PaxDb P30968
PRIDE P30968
DNASU 2798
Ensembl ENST00000226413
ENST00000420975
GeneID 2798
KEGG hsa:2798
UCSC uc003hdm.3
uc003hdn.3
CTD 2798
GeneCards GC04M068608
GeneReviews GNRHR
HGNC HGNC:4421
MIM 138850
146110
228300
neXtProt NX_P30968
Orphanet 432
PharmGKB PA28800
eggNOG NOG277514
GeneTree ENSGT00760000119156
HOGENOM HOG000251590
HOVERGEN HBG009082
InParanoid P30968
KO K04280
OMA AWILSGV
OrthoDB EOG71G9V8
PhylomeDB P30968
TreeFam TF106499
Reactome REACT_16942
REACT_18283
GeneWiki GNRHR
GenomeRNAi 2798
NextBio 11027
PRO PR:P30968
Proteomes UP000005640
Bgee P30968
CleanEx HS_GNRHR
ExpressionAtlas P30968
Genevestigator P30968
GO GO:0005887
GO:0016020
GO:0005886
GO:0004968
GO:0097211
GO:0007186
GO:0007275
InterPro IPR000276
IPR017452
IPR001658
IPR027982
PANTHER PTHR24241:SF22
Pfam PF00001
PRINTS PR00529
PR00237
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0032870

cellular response to hormone stimulus

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001202348
RGD:2289

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0025595
PANTHER:PTN001202348
RGD:3239
RGD:61886
RGD:70513
ZFIN:ZDB-GENE-050419-76
ZFIN:ZDB-GENE-090128-3

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0038880
PANTHER:PTN001202348

C

Seeded From UniProt

complete

enables

GO:0004968

gonadotropin-releasing hormone receptor activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001202351
ZFIN:ZDB-GENE-090128-2
ZFIN:ZDB-GENE-090128-3

F

Seeded From UniProt

complete

involved_in

GO:0097211

cellular response to gonadotropin-releasing hormone

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004968

P

Seeded From UniProt

complete

involved_in

GO:0097211

cellular response to gonadotropin-releasing hormone

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004968

P

Seeded From UniProt

complete

involved_in

GO:0097211

cellular response to gonadotropin-releasing hormone

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004968

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

enables

GO:0004968

gonadotropin-releasing hormone receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027982

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR001658
InterPro:IPR027982

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR001658
InterPro:IPR017452
InterPro:IPR027982

C

Seeded From UniProt

complete

enables

GO:0016500

protein-hormone receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001658

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

PMID:10686191[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:8386108[3]
Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

enables

GO:0004968

gonadotropin-releasing hormone receptor activity

PMID:8386108[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:9259321[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:8386108[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-749452
Reactome:R-HSA-749448
Reactome:R-HSA-391372
Reactome:R-HSA-379048

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ Albano, C et al. (2000) Ovarian stimulation with HMG: results of a prospective randomized phase III European study comparing the luteinizing hormone-releasing hormone (LHRH)-antagonist cetrorelix and the LHRH-agonist buserelin. European Cetrorelix Study Group. Hum. Reprod. 15 526-31 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Chi, L et al. (1993) Cloning and characterization of the human GnRH receptor. Mol. Cell. Endocrinol. 91 R1-6 PubMed GONUTS page
  4. ↑ Grosse, R et al. (1997) Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor. Mol. Endocrinol. 11 1305-18 PubMed GONUTS page
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