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HUMAN:GLSK

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) GLS (synonyms: GLS1, KIAA0838)
Protein Name(s) Glutaminase kidney isoform, mitochondrial

GLS K-glutaminase L-glutamine amidohydrolase

External Links
UniProt O94925
EMBL AF158555
AF097492
AF097493
AF097495
AB020645
AF223943
AF327434
BC038507
AF279697
CCDS CCDS2308.1
CCDS58744.1
RefSeq NP_001243239.1
NP_055720.3
UniGene Hs.116448
Hs.737608
PDB 3CZD
3UNW
3UO9
3VOY
3VOZ
3VP0
3VP1
3VP2
3VP3
3VP4
4O7D
PDBsum 3CZD
3UNW
3UO9
3VOY
3VOZ
3VP0
3VP1
3VP2
3VP3
3VP4
4O7D
ProteinModelPortal O94925
SMR O94925
BioGrid 109006
DIP DIP-50591N
IntAct O94925
MINT MINT-4096121
STRING 9606.ENSP00000317379
BindingDB O94925
ChEMBL CHEMBL2146302
DrugBank DB00130
PhosphoSite O94925
MaxQB O94925
PaxDb O94925
PeptideAtlas O94925
PRIDE O94925
DNASU 2744
Ensembl ENST00000320717
ENST00000338435
GeneID 2744
KEGG hsa:2744
UCSC uc002usd.2
uc002use.3
uc002usf.3
CTD 2744
GeneCards GC02P191709
H-InvDB HIX0161645
HGNC HGNC:4331
HPA HPA036223
MIM 138280
neXtProt NX_O94925
PharmGKB PA28734
eggNOG COG2066
GeneTree ENSGT00390000010463
HOGENOM HOG000216891
HOVERGEN HBG005856
InParanoid O94925
KO K01425
OMA QCCSMEA
OrthoDB EOG7S4X5F
PhylomeDB O94925
TreeFam TF313359
BRENDA 3.5.1.2
Reactome REACT_12591
REACT_238
ChiTaRS GLS
EvolutionaryTrace O94925
GenomeRNAi 2744
NextBio 10816
PRO PR:O94925
Proteomes UP000005640
Bgee O94925
CleanEx HS_GLS
ExpressionAtlas O94925
Genevestigator O94925
GO GO:0005829
GO:0005759
GO:0005739
GO:0004359
GO:0008652
GO:0034641
GO:0006537
GO:0014047
GO:0006543
GO:0007269
GO:0051289
GO:0002087
GO:0044281
GO:0001967
GO:0007268
Gene3D 1.25.40.20
3.40.710.10
HAMAP MF_00313
InterPro IPR002110
IPR020683
IPR012338
IPR015868
PANTHER PTHR12544
Pfam PF12796
PF04960
SMART SM00248
SUPFAM SSF48403
SSF56601
TIGRFAMs TIGR03814
PROSITE PS50297
PS50088

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004359

glutaminase activity

PMID:10719215[1]

ECO:0000247

PMID:10719215[1]


F

figure 3

complete
CACAO 4516

involved_in

GO:0051289

protein homotetramerization

PMID:22049910[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006543

glutamine catabolic process

PMID:22049910[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006543

glutamine catabolic process

PMID:10719215[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006537

glutamate biosynthetic process

PMID:22049910[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006537

glutamate biosynthetic process

PMID:16899818[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:16899818[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:10719215[1]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004359

glutaminase activity

PMID:22049910[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004359

glutaminase activity

PMID:10719215[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004359

glutaminase activity

PMID:11015561[4]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006543

glutamine catabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13816
MGI:MGI:95752
PANTHER:PTN000283994
UniProtKB:O94925

P

Seeded From UniProt

complete

involved_in

GO:0006537

glutamate biosynthetic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95752
PANTHER:PTN000283994
UniProtKB:O94925

P

Seeded From UniProt

complete

enables

GO:0004359

glutaminase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13247
EcoGene:EG13816
MGI:MGI:95752
PANTHER:PTN000283994
UniProtKB:O94925

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051289

protein homotetramerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3Z7P3
ensembl:ENSMUSP00000110158

P

Seeded From UniProt

complete

involved_in

GO:0007268

chemical synaptic transmission

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3Z7P3
ensembl:ENSMUSP00000110158

P

Seeded From UniProt

complete

involved_in

GO:0006543

glutamine catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3Z7P3
ensembl:ENSMUSP00000110158

P

Seeded From UniProt

complete

involved_in

GO:0006537

glutamate biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3Z7P3
ensembl:ENSMUSP00000110158

P

Seeded From UniProt

complete

enables

GO:0004359

glutaminase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3Z7P3
ensembl:ENSMUSP00000110158

F

Seeded From UniProt

complete

involved_in

GO:0002087

regulation of respiratory gaseous exchange by neurological system process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3Z7P3
ensembl:ENSMUSP00000110158

P

Seeded From UniProt

complete

involved_in

GO:0001967

suckling behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3Z7P3
ensembl:ENSMUSP00000110158

P

Seeded From UniProt

complete

enables

GO:0004359

glutaminase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015868

F

Seeded From UniProt

complete

involved_in

GO:0006541

glutamine metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015868

P

Seeded From UniProt

complete

enables

GO:0004359

glutaminase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.1.2

F

Seeded From UniProt

complete

involved_in

GO:0006537

glutamate biosynthetic process

PMID:21757002[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0014047

glutamate secretion

Reactome:R-HSA-210500

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008652

cellular amino acid biosynthetic process

Reactome:R-HSA-70614

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

Reactome:R-HSA-70609

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Holcomb, T et al. (2000) Isolation, characterization and expression of a human brain mitochondrial glutaminase cDNA. Brain Res. Mol. Brain Res. 76 56-63 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 DeLaBarre, B et al. (2011) Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry 50 10764-70 PubMed GONUTS page
  3. ↑ 3.0 3.1 Buschdorf, JP et al. (2006) Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels. J. Cell. Sci. 119 3337-50 PubMed GONUTS page
  4. ↑ Elgadi, KM et al. (1999) Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing. Physiol. Genomics 1 51-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Renga, B et al. (2011) The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate. Biochim. Biophys. Acta 1812 1522-31 PubMed GONUTS page
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