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HUMAN:GHSR
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | GHSR | |
| Protein Name(s) | Growth hormone secretagogue receptor type 1
GHS-R GH-releasing peptide receptor GHRP Ghrelin receptor | |
| External Links | ||
| UniProt | Q92847 | |
| EMBL | U60179 U60181 AF369786 AF369786 AY429112 AY322544 CH471052 BC069068 BC069374 BC113547 | |
| CCDS | CCDS3218.1 CCDS46959.1 | |
| RefSeq | NP_004113.1 NP_940799.1 | |
| UniGene | Hs.130212 | |
| ProteinModelPortal | Q92847 | |
| SMR | Q92847 | |
| STRING | 9606.ENSP00000241256 | |
| BindingDB | Q92847 | |
| ChEMBL | CHEMBL4616 | |
| GuidetoPHARMACOLOGY | 246 | |
| TCDB | 9.A.14.1.6 | |
| DMDM | 2494998 | |
| PRIDE | Q92847 | |
| DNASU | 2693 | |
| Ensembl | ENST00000241256 ENST00000427970 | |
| GeneID | 2693 | |
| KEGG | hsa:2693 | |
| UCSC | uc003fib.2 uc011bpv.2 | |
| CTD | 2693 | |
| GeneCards | GC03M172162 | |
| HGNC | HGNC:4267 | |
| HPA | CAB012451 | |
| MIM | 601898 604271 | |
| neXtProt | NX_Q92847 | |
| Orphanet | 314811 | |
| PharmGKB | PA28677 | |
| eggNOG | NOG303294 | |
| GeneTree | ENSGT00700000104070 | |
| HOGENOM | HOG000272571 | |
| HOVERGEN | HBG006538 | |
| InParanoid | Q92847 | |
| KO | K04284 | |
| OMA | DTNECRA | |
| OrthoDB | EOG7992QV | |
| PhylomeDB | Q92847 | |
| TreeFam | TF332184 | |
| Reactome | REACT_14819 REACT_18283 | |
| GeneWiki | Growth_hormone_secretagogue_receptor | |
| GenomeRNAi | 2693 | |
| NextBio | 10650 | |
| PRO | PR:Q92847 | |
| Proteomes | UP000005640 | |
| Bgee | Q92847 | |
| CleanEx | HS_GHSR | |
| Genevestigator | Q92847 | |
| GO | GO:0009986 GO:0016021 GO:0045121 GO:0043005 GO:0005886 GO:0004930 GO:0001616 GO:0016520 GO:0017046 GO:0008154 GO:0008343 GO:0032869 GO:0046697 GO:0007186 GO:0030252 GO:0009755 GO:0050728 GO:0046676 GO:0032691 GO:0045409 GO:0042536 GO:0032100 GO:0045923 GO:0043568 GO:0040018 GO:0043134 GO:0051963 GO:0032094 GO:0009725 | |
| InterPro | IPR003905 IPR000276 IPR017452 | |
| Pfam | PF00001 | |
| PRINTS | PR01417 PR00237 | |
| PROSITE | PS00237 PS50262 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0040018 |
positive regulation of multicellular organism growth |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032100 |
positive regulation of appetite |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016520 |
growth hormone-releasing hormone receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009755 |
hormone-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008343 |
adult feeding behavior |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001616 |
growth hormone secretagogue receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050728 |
negative regulation of inflammatory response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046697 |
decidualization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045409 |
negative regulation of interleukin-6 biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000084) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042536 |
negative regulation of tumor necrosis factor biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032691 |
negative regulation of interleukin-1 beta production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009725 |
response to hormone |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008154 |
actin polymerization or depolymerization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0098794 |
postsynapse |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0099170 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000110 |
negative regulation of macrophage apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1990314 |
cellular response to insulin-like growth factor stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1905564 |
positive regulation of vascular endothelial cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1905333 |
regulation of gastric motility |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904468 |
negative regulation of tumor necrosis factor secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904349 |
positive regulation of small intestine smooth muscle contraction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904008 |
response to monosodium glutamate |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904000 |
positive regulation of eating behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903672 |
positive regulation of sprouting angiogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0120058 |
positive regulation of small intestinal transit |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0099699 |
integral component of synaptic membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0099175 |
regulation of postsynapse organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0099170 |
postsynaptic modulation of chemical synaptic transmission |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0098696 |
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098685 |
Schaffer collateral - CA1 synapse |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097067 |
cellular response to thyroid hormone stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090327 |
negative regulation of locomotion involved in locomotory behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071548 |
response to dexamethasone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060416 |
response to growth hormone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060259 |
regulation of feeding behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060123 |
regulation of growth hormone secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051969 |
regulation of transmission of nerve impulse |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046676 |
negative regulation of insulin secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045927 |
positive regulation of growth |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045923 |
positive regulation of fatty acid metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043134 |
regulation of hindgut contraction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042562 |
hormone binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0036321 |
ghrelin secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032355 |
response to estradiol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032354 |
response to follicle-stimulating hormone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032099 |
negative regulation of appetite |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017046 |
peptide hormone binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010700 |
negative regulation of norepinephrine secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007611 |
learning or memory |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007565 |
female pregnancy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007283 |
spermatogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001616 |
growth hormone secretagogue receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08725 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051963 |
regulation of synapse assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99P50 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043568 |
positive regulation of insulin-like growth factor receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99P50 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99P50 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032100 |
positive regulation of appetite |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99P50 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032094 |
response to food |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99P50 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030252 |
growth hormone secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99P50 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008343 |
adult feeding behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99P50 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001616 |
growth hormone secretagogue receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030252 |
growth hormone secretion |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
Reactome:R-HSA-388396 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-749452 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Pantel, J et al. (2006) Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature. J. Clin. Invest. 116 760-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Howard, AD et al. (1996) A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273 974-7 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Dixit, VD et al. (2004) Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J. Clin. Invest. 114 57-66 PubMed GONUTS page
- ↑ Tawadros, N et al. (2007) Facilitation of decidualization by locally produced ghrelin in the human endometrium. Mol. Hum. Reprod. 13 483-9 PubMed GONUTS page
- ↑ Dass, NB et al. (2003) Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin. Neuroscience 120 443-53 PubMed GONUTS page
c
g
- GO:0036321 ! ghrelin secretion
- GO:0098978 ! glutamatergic synapse
- GO:0030252 ! growth hormone secretion
- GO:0001616 ! growth hormone secretagogue receptor activity
- GO:0016520 ! growth hormone-releasing hormone receptor activity
- GO:0004930 ! G protein-coupled receptor activity
- GO:0007186 ! G protein-coupled receptor signaling pathway
h
n
- GO:2000110 ! negative regulation of macrophage apoptotic process
- GO:0010700 ! negative regulation of norepinephrine secretion
- GO:0032099 ! negative regulation of appetite
- GO:1904468 ! negative regulation of tumor necrosis factor secretion
- GO:0050728 ! negative regulation of inflammatory response
- GO:0046676 ! negative regulation of insulin secretion
- GO:0045409 ! negative regulation of interleukin-6 biosynthetic process
- GO:0042536 ! negative regulation of tumor necrosis factor biosynthetic process
- GO:0090327 ! negative regulation of locomotion involved in locomotory behavior
- GO:0032691 ! negative regulation of interleukin-1 beta production
- GO:0043005 ! neuron projection
o
p
- GO:0017046 ! peptide hormone binding
- GO:0005886 ! plasma membrane
- GO:0043568 ! positive regulation of insulin-like growth factor receptor signaling pathway
- GO:0040018 ! positive regulation of multicellular organism growth
- GO:1903672 ! positive regulation of sprouting angiogenesis
- GO:1904000 ! positive regulation of eating behavior
- GO:1904349 ! positive regulation of small intestine smooth muscle contraction
- GO:0120058 ! positive regulation of small intestinal transit
- GO:1905564 ! positive regulation of vascular endothelial cell proliferation
- GO:0032100 ! positive regulation of appetite
- GO:0045927 ! positive regulation of growth
- GO:0045923 ! positive regulation of fatty acid metabolic process
- GO:0098794 ! postsynapse
- GO:0099170 ! postsynaptic modulation of chemical synaptic transmission
- Primates
r
- GO:0051963 ! regulation of synapse assembly
- GO:0051969 ! regulation of transmission of nerve impulse
- GO:0060123 ! regulation of growth hormone secretion
- GO:1905333 ! regulation of gastric motility
- GO:0098696 ! regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
- GO:0099175 ! regulation of postsynapse organization
- GO:0043134 ! regulation of hindgut contraction
- GO:0060259 ! regulation of feeding behavior
- GO:0009725 ! response to hormone
- GO:0032354 ! response to follicle-stimulating hormone
- GO:0032355 ! response to estradiol
- GO:0071548 ! response to dexamethasone
- GO:0060416 ! response to growth hormone
- GO:0032094 ! response to food
s
