HUMAN:GHRL

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	GHRL (synonyms: MTLRP)
Protein Name(s)	Appetite-regulating hormone Growth hormone secretagogue Growth hormone-releasing peptide Motilin-related peptide Protein M46 Ghrelin-27 Ghrelin-28 Ghrelin Obestatin
External Links
UniProt	Q9UBU3
EMBL	AB029434 AJ252278 AF296558 EU072086 EF549569 EF549571 EF549572 EF549573 EF549574 EF549575 EU072083 EU072084 EU072085 EU072087 AY184207 AY359053 AC022384 CH471055 CH471055 BC025791 AB035700
CCDS	CCDS33700.1 CCDS46747.1 CCDS46748.1 CCDS46749.1 CCDS46750.1
PIR	A59316
RefSeq	NP_001128413.1 NP_001128416.1 NP_001128417.1 NP_001128418.1 NP_057446.1
UniGene	Hs.590080 Hs.672979
PDB	1P7X
PDBsum	1P7X
ProteinModelPortal	Q9UBU3
BioGrid	119706
STRING	9606.ENSP00000335074
BindingDB	Q9UBU3
ChEMBL	CHEMBL1921664
PhosphoSite	Q9UBU3
DMDM	17865471
PaxDb	Q9UBU3
PRIDE	Q9UBU3
DNASU	51738
Ensembl	ENST00000287656 ENST00000335542 ENST00000422159 ENST00000429122 ENST00000430179 ENST00000437422 ENST00000439975 ENST00000449238 ENST00000457360
GeneID	51738
KEGG	hsa:51738
UCSC	uc003bvj.1 uc010hdc.2 uc010hde.2 uc010hdf.2 uc010hdj.2 uc010hdk.2
CTD	51738
GeneCards	GC03M010302
HGNC	HGNC:18129
HPA	CAB022731 HPA014246
MIM	605353
neXtProt	NX_Q9UBU3
PharmGKB	PA142671740
eggNOG	NOG45924
GeneTree	ENSGT00390000004064
HOVERGEN	HBG018522
InParanoid	Q9UBU3
KO	K05254
OMA	EIQFNAP
OrthoDB	EOG741Z4K
PhylomeDB	Q9UBU3
TreeFam	TF336219
Reactome	REACT_14819 REACT_18283 REACT_19189
GeneWiki	Ghrelin
GenomeRNAi	51738
NextBio	55808
PMAP-CutDB	Q9UBU3
PRO	PR:Q9UBU3
Proteomes	UP000005640
Bgee	Q9UBU3
CleanEx	HS_GHRL
ExpressionAtlas	Q9UBU3
Genevestigator	Q9UBU3
GO	GO:0030424 GO:0005788 GO:0005576 GO:0005615 GO:0034774 GO:0001664 GO:0031768 GO:0016608 GO:0030296 GO:0008154 GO:0000187 GO:0008343 GO:0051216 GO:0044267 GO:0043400 GO:0046697 GO:0016358 GO:0007186 GO:0001696 GO:0006006 GO:0030252 GO:0009755 GO:0016525 GO:0043066 GO:0042322 GO:0001937 GO:0050728 GO:0046676 GO:0032691 GO:0045409 GO:0040013 GO:0042536 GO:0032100 GO:0046010 GO:0051461 GO:0051464 GO:0007204 GO:0060399 GO:0060124 GO:0032024 GO:0040018 GO:0061098 GO:0051965 GO:0042127 GO:0060079 GO:0043627 GO:0009725
InterPro	IPR006737 IPR006738 IPR005441
PANTHER	PTHR14122
Pfam	PF04643 PF04644
PRINTS	PR01624

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0016608	growth hormone-releasing hormone activity	PMID:20161791^[1]	ECO:0000314			F	Figure 1 shows that Ghrelin increases the action potential of the neurons associated with the growth hormone-releasing hormone (GHRH). This shows that the increase of Ghrelin on the GHRH neurons occurs in both males and females.	complete CACAO 9471
	GO:0031768	ghrelin receptor binding	PMID:10930375^[2]	ECO:0000314			F	Figure 5 Colocalization of m46 and chromogranin A, serotonin, and somatostatin in gastric cells.	complete CACAO 3521
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:19666521^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQX0	P	Seeded From UniProt	complete
involved_in	GO:0060399	positive regulation of growth hormone receptor signaling pathway	PMID:12566947^[4]	ECO:0000305	curator inference used in manual assertion	GO:0060124	P	Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	PMID:18329818^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	PMID:12566947^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051464	positive regulation of cortisol secretion	PMID:18329818^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051464	positive regulation of cortisol secretion	PMID:12566947^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051461	positive regulation of corticotropin secretion	PMID:12566947^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	PMID:18329818^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep	PMID:18329818^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0040018	positive regulation of multicellular organism growth	PMID:16511605^[6]	ECO:0000305	curator inference used in manual assertion	GO:0031768	P	Seeded From UniProt	complete
involved_in	GO:0032100	positive regulation of appetite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQX0-1	P	Seeded From UniProt	complete
involved_in	GO:0008343	adult feeding behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQX0-1	P	Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	PMID:15576457^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:15232612^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	PMID:17494105^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045409	negative regulation of interleukin-6 biosynthetic process	PMID:15232612^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:15292338^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043400	cortisol secretion	PMID:17201814^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:15158140^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process	PMID:15232612^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:15564328^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:16394173^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032691	negative regulation of interleukin-1 beta production	PMID:15232612^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYH7	P	Seeded From UniProt	complete
enables	GO:0031768	ghrelin receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYH7	F	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:17113048^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0030296	protein tyrosine kinase activator activity	PMID:15350694^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0016608	growth hormone-releasing hormone activity	PMID:10604470^[17]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYH7	F	Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:15572208^[18]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	PMID:15232612^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008154	actin polymerization or depolymerization	PMID:15232612^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYH7	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:10604470^[17]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYH7	P	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	PMID:17392603^[19]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15531532^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15039149^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:17392603^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	PMID:15572208^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	PMID:10604470^[17]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYH7	F	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:15350694^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283 UniProtKB:Q9UBU3	P	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 UniProtKB:Q9UBU3	P	Seeded From UniProt	complete
involved_in	GO:0032095	regulation of response to food	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283	P	Seeded From UniProt	complete
enables	GO:0031768	ghrelin receptor binding	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283 UniProtKB:Q8AV73	F	Seeded From UniProt	complete
enables	GO:0016608	growth hormone-releasing hormone activity	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 UniProtKB:Q8AV73 UniProtKB:Q9GKY5 UniProtKB:Q9UBU3	C	Seeded From UniProt	complete
involved_in	GO:0001696	gastric acid secretion	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283	P	Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	PMID:16491079^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	PMID:16491079^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016608	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016608	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016608	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016608	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030296	P	Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0060079	C	Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0099170	C	Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P	Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P	Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P	Seeded From UniProt	complete
involved_in	GO:0046676	negative regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P	Seeded From UniProt	complete
involved_in	GO:0040013	negative regulation of locomotion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P	Seeded From UniProt	complete
involved_in	GO:0032100	positive regulation of appetite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P	Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	C	Seeded From UniProt	complete
involved_in	GO:2000253	positive regulation of feeding behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:1905564	positive regulation of vascular endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:1905333	regulation of gastric motility	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:1904468	negative regulation of tumor necrosis factor secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:1904349	positive regulation of small intestine smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:1904346	positive regulation of gastric mucosal blood circulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:1904306	positive regulation of gastro-intestinal system smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:1904179	positive regulation of adipose tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:1904000	positive regulation of eating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:1903012	positive regulation of bone development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0120058	positive regulation of small intestinal transit	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0099175	regulation of postsynapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0099170	postsynaptic modulation of chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	C	Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	C	Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0051969	regulation of transmission of nerve impulse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0046676	negative regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0045927	positive regulation of growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0040010	positive regulation of growth rate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0035483	gastric emptying	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0032691	negative regulation of interleukin-1 beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0032100	positive regulation of appetite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0032097	positive regulation of response to food	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0032095	regulation of response to food	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
enables	GO:0031768	ghrelin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	F	Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
enables	GO:0016608	growth hormone-releasing hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	F	Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	F	Seeded From UniProt	complete
involved_in	GO:0001696	gastric acid secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P	Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	F	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006737 InterPro:IPR006738	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005441 InterPro:IPR006737 InterPro:IPR006738	C	Seeded From UniProt	complete
enables	GO:0016608	growth hormone-releasing hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005441	F	Seeded From UniProt	complete
enables	GO:0031768	ghrelin receptor binding	PMID:16511605^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0030252	growth hormone secretion	PMID:16511605^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016608	growth hormone-releasing hormone activity	PMID:16511605^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0009755	hormone-mediated signaling pathway	PMID:16511605^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:16511605^[6] Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0034774	secretory granule lumen	Reactome:R-HSA-422048 Reactome:R-HSA-422021	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-422104 Reactome:R-HSA-422088 Reactome:R-HSA-422051 Reactome:R-HSA-422017	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-9023619 Reactome:R-HSA-9023617 Reactome:R-HSA-749452 Reactome:R-HSA-749448 Reactome:R-HSA-422048 Reactome:R-HSA-379048	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Osterstock, G et al. (2010) Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus. PLoS ONE 5 e9159 PubMed GONUTS page
↑ Tomasetto, C et al. (2000) Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology 119 395-405 PubMed GONUTS page
↑ Szentirmai, E et al. (2009) The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice. Proc. Natl. Acad. Sci. U.S.A. 106 14069-74 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Leal-Cerro, A et al. (2002) Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses. Neuroendocrinology 76 390-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Kluge, M et al. (2008) Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males. Psychoneuroendocrinology 33 497-506 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Pantel, J et al. (2006) Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature. J. Clin. Invest. 116 760-8 PubMed GONUTS page
↑ Caminos, JE et al. (2005) The endogenous growth hormone secretagogue (ghrelin) is synthesized and secreted by chondrocytes. Endocrinology 146 1285-92 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Dixit, VD et al. (2004) Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J. Clin. Invest. 114 57-66 PubMed GONUTS page
↑ Tawadros, N et al. (2007) Facilitation of decidualization by locally produced ghrelin in the human endometrium. Mol. Hum. Reprod. 13 483-9 PubMed GONUTS page
↑ Grinspoon, S et al. (2004) Effects of estrogen and recombinant human insulin-like growth factor-I on ghrelin secretion in severe undernutrition. J. Clin. Endocrinol. Metab. 89 3988-93 PubMed GONUTS page
↑ Huber, J et al. (2007) Ghrelin does not regulate the GH response to insulin-induced hypoglycaemia in children but could be involved in the regulation of cortisol secretion. Clin. Endocrinol. (Oxf) 66 143-7 PubMed GONUTS page
↑ Iglesias, MJ et al. (2004) Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes. Cardiovasc. Res. 62 481-8 PubMed GONUTS page
↑ De Vriese, C et al. (2005) Ghrelin is produced by the human erythroleukemic HEL cell line and involved in an autocrine pathway leading to cell proliferation. Endocrinology 146 1514-22 PubMed GONUTS page
↑ Delhanty, PJ et al. (2006) Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a. J. Endocrinol. 188 37-47 PubMed GONUTS page
↑ Menyhért, J et al. (2006) Distribution of ghrelin-immunoreactive neuronal networks in the human hypothalamus. Brain Res. 1125 31-6 PubMed GONUTS page
↑ ^16.0 ^16.1 Mazzocchi, G et al. (2004) Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects. Peptides 25 1269-77 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Kojima, M et al. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 656-60 PubMed GONUTS page
↑ ^18.0 ^18.1 Conconi, MT et al. (2004) Ghrelin inhibits FGF-2-mediated angiogenesis in vitro and in vivo. Peptides 25 2179-85 PubMed GONUTS page
↑ ^19.0 ^19.1 Lányi, E et al. (2007) Plasma levels of acylated ghrelin during an oral glucose tolerance test in obese children. J. Endocrinol. Invest. 30 133-7 PubMed GONUTS page
↑ Hotta, M et al. (2004) Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa. J. Clin. Endocrinol. Metab. 89 5707-12 PubMed GONUTS page
↑ Cummings, DE et al. (2004) Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues. Am. J. Physiol. Endocrinol. Metab. 287 E297-304 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^23.0 ^23.1 Diano, S et al. (2006) Ghrelin controls hippocampal spine synapse density and memory performance. Nat. Neurosci. 9 381-8 PubMed GONUTS page

[PMID:20161791-1] Osterstock, G et al. (2010) Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus. PLoS ONE 5 e9159 PubMed GONUTS page

[PMID:10930375-2] Tomasetto, C et al. (2000) Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology 119 395-405 PubMed GONUTS page

[PMID:19666521-3] Szentirmai, E et al. (2009) The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice. Proc. Natl. Acad. Sci. U.S.A. 106 14069-74 PubMed GONUTS page

[PMID:12566947-4] 4.0 ^4.1 ^4.2 ^4.3 Leal-Cerro, A et al. (2002) Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses. Neuroendocrinology 76 390-6 PubMed GONUTS page

[PMID:18329818-5] 5.0 ^5.1 ^5.2 ^5.3 Kluge, M et al. (2008) Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males. Psychoneuroendocrinology 33 497-506 PubMed GONUTS page

[PMID:16511605-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Pantel, J et al. (2006) Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature. J. Clin. Invest. 116 760-8 PubMed GONUTS page

[PMID:15576457-7] Caminos, JE et al. (2005) The endogenous growth hormone secretagogue (ghrelin) is synthesized and secreted by chondrocytes. Endocrinology 146 1285-92 PubMed GONUTS page

[PMID:15232612-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Dixit, VD et al. (2004) Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J. Clin. Invest. 114 57-66 PubMed GONUTS page

[PMID:17494105-9] Tawadros, N et al. (2007) Facilitation of decidualization by locally produced ghrelin in the human endometrium. Mol. Hum. Reprod. 13 483-9 PubMed GONUTS page

[PMID:15292338-10] Grinspoon, S et al. (2004) Effects of estrogen and recombinant human insulin-like growth factor-I on ghrelin secretion in severe undernutrition. J. Clin. Endocrinol. Metab. 89 3988-93 PubMed GONUTS page

[PMID:17201814-11] Huber, J et al. (2007) Ghrelin does not regulate the GH response to insulin-induced hypoglycaemia in children but could be involved in the regulation of cortisol secretion. Clin. Endocrinol. (Oxf) 66 143-7 PubMed GONUTS page

[PMID:15158140-12] Iglesias, MJ et al. (2004) Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes. Cardiovasc. Res. 62 481-8 PubMed GONUTS page

[PMID:15564328-13] De Vriese, C et al. (2005) Ghrelin is produced by the human erythroleukemic HEL cell line and involved in an autocrine pathway leading to cell proliferation. Endocrinology 146 1514-22 PubMed GONUTS page

[PMID:16394173-14] Delhanty, PJ et al. (2006) Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a. J. Endocrinol. 188 37-47 PubMed GONUTS page

[PMID:17113048-15] Menyhért, J et al. (2006) Distribution of ghrelin-immunoreactive neuronal networks in the human hypothalamus. Brain Res. 1125 31-6 PubMed GONUTS page

[PMID:15350694-16] 16.0 ^16.1 Mazzocchi, G et al. (2004) Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects. Peptides 25 1269-77 PubMed GONUTS page

[PMID:10604470-17] 17.0 ^17.1 ^17.2 Kojima, M et al. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 656-60 PubMed GONUTS page

[PMID:15572208-18] 18.0 ^18.1 Conconi, MT et al. (2004) Ghrelin inhibits FGF-2-mediated angiogenesis in vitro and in vivo. Peptides 25 2179-85 PubMed GONUTS page

[PMID:17392603-19] 19.0 ^19.1 Lányi, E et al. (2007) Plasma levels of acylated ghrelin during an oral glucose tolerance test in obese children. J. Endocrinol. Invest. 30 133-7 PubMed GONUTS page

[PMID:15531532-20] Hotta, M et al. (2004) Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa. J. Clin. Endocrinol. Metab. 89 5707-12 PubMed GONUTS page

[PMID:15039149-21] Cummings, DE et al. (2004) Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues. Am. J. Physiol. Endocrinol. Metab. 287 E297-304 PubMed GONUTS page

[PMID:21873635-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16491079-23] 23.0 ^23.1 Diano, S et al. (2006) Ghrelin controls hippocampal spine synapse density and memory performance. Nat. Neurosci. 9 381-8 PubMed GONUTS page

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