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HUMAN:GCDH
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | GCDH | |
| Protein Name(s) | Glutaryl-CoA dehydrogenase, mitochondrial
GCD | |
| External Links | ||
| UniProt | Q92947 | |
| EMBL | U69141 AF012342 AF012339 AF012340 AF012341 BT006706 AK290407 AD000092 CH471106 BC002579 | |
| CCDS | CCDS12286.1 | |
| PIR | T44260 T45073 | |
| RefSeq | NP_000150.1 NP_039663.1 | |
| UniGene | Hs.532699 | |
| PDB | 1SIQ 1SIR 2R0M 2R0N | |
| PDBsum | 1SIQ 1SIR 2R0M 2R0N | |
| ProteinModelPortal | Q92947 | |
| SMR | Q92947 | |
| BioGrid | 108909 | |
| IntAct | Q92947 | |
| STRING | 9606.ENSP00000222214 | |
| DrugBank | DB03147 | |
| PhosphoSite | Q92947 | |
| DMDM | 2492631 | |
| MaxQB | Q92947 | |
| PaxDb | Q92947 | |
| PRIDE | Q92947 | |
| DNASU | 2639 | |
| Ensembl | ENST00000222214 ENST00000591470 | |
| GeneID | 2639 | |
| KEGG | hsa:2639 | |
| UCSC | uc002mvp.4 uc002mvq.4 | |
| CTD | 2639 | |
| GeneCards | GC19P013001 | |
| HGNC | HGNC:4189 | |
| HPA | HPA043252 HPA048492 | |
| MIM | 231670 608801 | |
| neXtProt | NX_Q92947 | |
| Orphanet | 25 | |
| PharmGKB | PA28604 | |
| eggNOG | COG1960 | |
| GeneTree | ENSGT00760000119007 | |
| HOGENOM | HOG000131662 | |
| HOVERGEN | HBG001939 | |
| InParanoid | Q92947 | |
| KO | K00252 | |
| OMA | RCEDGCI | |
| PhylomeDB | Q92947 | |
| TreeFam | TF105051 | |
| BRENDA | 1.3.99.7 | |
| Reactome | REACT_1298 | |
| SABIO-RK | Q92947 | |
| UniPathway | UPA00224 UPA00225 | |
| ChiTaRS | GCDH | |
| EvolutionaryTrace | Q92947 | |
| GenomeRNAi | 2639 | |
| NextBio | 10404 | |
| PRO | PR:Q92947 | |
| Proteomes | UP000005640 | |
| Bgee | Q92947 | |
| CleanEx | HS_GCDH | |
| ExpressionAtlas | Q92947 | |
| Genevestigator | Q92947 | |
| GO | GO:0005743 GO:0005759 GO:0005739 GO:0000062 GO:0050660 GO:0004361 GO:0034641 GO:0019395 GO:0046949 GO:0006554 GO:0044281 GO:0006568 | |
| Gene3D | 1.10.540.10 2.40.110.10 | |
| InterPro | IPR006089 IPR006091 IPR009075 IPR013786 IPR009100 | |
| Pfam | PF00441 PF02770 PF02771 | |
| SUPFAM | SSF47203 SSF56645 | |
| PROSITE | PS00072 PS00073 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0033539 |
fatty acid beta-oxidation using acyl-CoA dehydrogenase |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000098492 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050660 |
flavin adenine dinucleotide binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZT90 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046949 |
fatty-acyl-CoA biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZT90 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019395 |
fatty acid oxidation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZT90 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006637 |
acyl-CoA metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZT90 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZT90 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004361 |
glutaryl-CoA dehydrogenase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZT90 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000062 |
fatty-acyl-CoA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZT90 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003995 |
acyl-CoA dehydrogenase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016627 |
oxidoreductase activity, acting on the CH-CH group of donors |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR006091 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0050660 |
flavin adenine dinucleotide binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR006089 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044466 |
glutaryl-CoA hydrolase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004361 |
glutaryl-CoA dehydrogenase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006554 |
lysine catabolic process |
Reactome:R-HSA-71064 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005759 |
mitochondrial matrix |
Reactome:R-HSA-71046 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006568 |
tryptophan metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00224 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Małecki, J et al. (2015) Human METTL20 is a mitochondrial lysine methyltransferase that targets the β subunit of electron transfer flavoprotein (ETFβ) and modulates its activity. J. Biol. Chem. 290 423-34 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 Goodman, SI et al. (1995) Cloning of glutaryl-CoA dehydrogenase cDNA, and expression of wild type and mutant enzymes in Escherichia coli. Hum. Mol. Genet. 4 1493-8 PubMed GONUTS page
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