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HUMAN:GALK1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) GALK1 (synonyms: GALK)
Protein Name(s) Galactokinase

Galactose kinase

External Links
UniProt P51570
EMBL U26401
L76927
AK303832
AK314890
BT007005
AC087749
CH471099
BC001166
CCDS CCDS11728.1
RefSeq NP_000145.1
UniGene Hs.407966
PDB 1WUU
1YH7
PDBsum 1WUU
1YH7
ProteinModelPortal P51570
SMR P51570
BioGrid 108857
IntAct P51570
MINT MINT-4999410
STRING 9606.ENSP00000225614
BindingDB P51570
ChEMBL CHEMBL1293257
PhosphoSite P51570
DMDM 1730187
OGP P51570
REPRODUCTION-2DPAGE IPI00019383
MaxQB P51570
PaxDb P51570
PRIDE P51570
DNASU 2584
Ensembl ENST00000225614
ENST00000588479
GeneID 2584
KEGG hsa:2584
UCSC uc002jpk.3
CTD 2584
GeneCards GC17M073730
HGNC HGNC:4118
HPA HPA007094
HPA016960
MIM 230200
604313
neXtProt NX_P51570
Orphanet 79237
PharmGKB PA28533
eggNOG COG0153
HOGENOM HOG000241100
HOVERGEN HBG051695
InParanoid P51570
KO K00849
OMA FANMPCG
OrthoDB EOG7K3TMV
PhylomeDB P51570
TreeFam TF354326
Reactome REACT_532
SABIO-RK P51570
UniPathway UPA00214
EvolutionaryTrace P51570
GenomeRNAi 2584
NextBio 10223
PRO PR:P51570
Proteomes UP000005640
Bgee P51570
CleanEx HS_GALK1
ExpressionAtlas P51570
Genevestigator P51570
GO GO:0005737
GO:0005829
GO:0070062
GO:0016020
GO:0005524
GO:0004335
GO:0005534
GO:0005975
GO:0019402
GO:0019388
GO:0006012
GO:0044281
Gene3D 3.30.230.10
3.30.70.890
InterPro IPR000705
IPR019741
IPR019539
IPR013750
IPR006204
IPR006203
IPR006206
IPR020568
IPR014721
Pfam PF10509
PF08544
PF00288
PIRSF PIRSF000530
PRINTS PR00473
PR00959
SUPFAM SSF54211
SSF55060
TIGRFAMs TIGR00131
PROSITE PS00106
PS00627

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0016020

membrane

PMID:19946888[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

NOT|part_of

GO:0016020

membrane

PMID:8908517[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006012

galactose metabolic process

PMID:15024738[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:8908517[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005534

galactose binding

PMID:14596685[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:12694189[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004335

galactokinase activity

PMID:12694189[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004335

galactokinase activity

PMID:7542884[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0033499

galactose catabolic process via UDP-galactose

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10363
PANTHER:PTN000048421
SGD:S000000224

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10363
PANTHER:PTN000048421
TAIR:locus:2075730
TAIR:locus:2084344
TAIR:locus:2130105

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10363
PANTHER:PTN000048421
SGD:S000000224
SGD:S000002416
UniProtKB:P51570

C

Seeded From UniProt

complete

enables

GO:0004335

galactokinase activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10363
MGI:MGI:95730
PANTHER:PTN000048421
RGD:1305375
SGD:S000000224
TAIR:locus:2075730
TAIR:locus:2084344
UniProtKB:P51570
UniProtKB:Q01415

F

Seeded From UniProt

complete

enables

GO:0004335

galactokinase activity

PMID:7542884[7]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0046835

carbohydrate phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5RKH2
ensembl:ENSRNOP00000008525

P

Seeded From UniProt

complete

involved_in

GO:0006012

galactose metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5RKH2
ensembl:ENSRNOP00000008525

P

Seeded From UniProt

complete

enables

GO:0005534

galactose binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5RKH2
ensembl:ENSRNOP00000008525

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5RKH2
ensembl:ENSRNOP00000008525

F

Seeded From UniProt

complete

enables

GO:0004335

galactokinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5RKH2
ensembl:ENSRNOP00000008525

F

Seeded From UniProt

complete

involved_in

GO:0061623

glycolytic process from galactose

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0N0
ensembl:ENSMUSP00000021114

P

Seeded From UniProt

complete

involved_in

GO:0019402

galactitol metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0N0
ensembl:ENSMUSP00000021114

P

Seeded From UniProt

complete

involved_in

GO:0006012

galactose metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0N0
ensembl:ENSMUSP00000021114

P

Seeded From UniProt

complete

enables

GO:0004335

galactokinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R0N0
ensembl:ENSMUSP00000021114

F

Seeded From UniProt

complete

enables

GO:0004335

galactokinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000705

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000705
InterPro:IPR006203
InterPro:IPR006204
InterPro:IPR006206

F

Seeded From UniProt

complete

enables

GO:0005534

galactose binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019539

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006206

C

Seeded From UniProt

complete

involved_in

GO:0006012

galactose metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000705

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006206

F

Seeded From UniProt

complete

enables

GO:0016773

phosphotransferase activity, alcohol group as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006206

F

Seeded From UniProt

complete

involved_in

GO:0046835

carbohydrate phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000705

P

Seeded From UniProt

complete

enables

GO:0004335

galactokinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.1.6

F

Seeded From UniProt

complete

involved_in

GO:0019388

galactose catabolic process

Reactome:R-HSA-70370

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-70355

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006012

galactose metabolic process

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0299
UniPathway:UPA00214

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0119

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  2. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  3. ↑ 3.0 3.1 Bergsma, DJ et al. (1996) Fine structure of the human galactokinase GALK1 gene. Genome Res. 6 980-5 PubMed GONUTS page
  4. ↑ Sangiuolo, F et al. (2004) Biochemical characterization of two GALK1 mutations in patients with galactokinase deficiency. Hum. Mutat. 23 396 PubMed GONUTS page
  5. ↑ Timson, DJ & Reece, RJ (2003) Sugar recognition by human galactokinase. BMC Biochem. 4 16 PubMed GONUTS page
  6. ↑ 6.0 6.1 Timson, DJ & Reece, RJ (2003) Functional analysis of disease-causing mutations in human galactokinase. Eur. J. Biochem. 270 1767-74 PubMed GONUTS page
  7. ↑ 7.0 7.1 Ai, Y et al. (1995) Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2. Biochem. Biophys. Res. Commun. 212 687-91 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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