HUMAN:GABR1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	GABBR1 (synonyms: GPRC3A)
Protein Name(s)	Gamma-aminobutyric acid type B receptor subunit 1 GABA-B receptor 1 GABA-B-R1 GABA-BR1 GABABR1 Gb1
External Links
UniProt	Q9UBS5
EMBL	AJ225028 AJ225029 AJ012185 AJ012186 AF099148 Y11044 AJ012187 AJ010170 AJ010171 AJ010172 AJ010173 AJ010174 AJ010175 AJ010176 AJ010177 AJ010178 AJ010179 AJ010180 AJ010181 AJ010182 AJ010183 AJ010184 AJ010185 AJ010186 AJ010187 AJ010188 AJ010189 AJ010190 AJ010191 AJ012288 AF301005 AL031983 AL031983 AL662826 AL662826 AL645936 AL645936 BX000688 BX000688 CR759766 CR759766 CR788300 CR936483 CR788300 CR936483 CR388210 CR759870 CR759870 CR936483 CR788300 CR936483 CR788300 CH471081 CH471081 BC042598 BC050532
CCDS	CCDS4663.1 CCDS4664.1 CCDS4665.1
PIR	JE0356
RefSeq	NP_001461.1 NP_068703.1 NP_068704.2
UniGene	Hs.167017
PDB	4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS
PDBsum	4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS
ProteinModelPortal	Q9UBS5
SMR	Q9UBS5
BioGrid	108825
DIP	DIP-38394N
IntAct	Q9UBS5
MINT	MINT-2793192
STRING	9606.ENSP00000388035
BindingDB	Q9UBS5
ChEMBL	CHEMBL2064
DrugBank	DB00181 DB00837 DB01080
GuidetoPHARMACOLOGY	240
PhosphoSite	Q9UBS5
DMDM	12643873
PaxDb	Q9UBS5
PRIDE	Q9UBS5
DNASU	2550
Ensembl	ENST00000355973 ENST00000376977 ENST00000377012 ENST00000377016 ENST00000377034 ENST00000383537 ENST00000383541 ENST00000383542 ENST00000383543 ENST00000383636 ENST00000383637 ENST00000383638 ENST00000383639 ENST00000414980 ENST00000417759 ENST00000419674 ENST00000423604 ENST00000425097 ENST00000434660 ENST00000438094 ENST00000439457 ENST00000443440 ENST00000446436 ENST00000448754 ENST00000449163 ENST00000452300 ENST00000458612 ENST00000494877 ENST00000546913 ENST00000547410 ENST00000548767 ENST00000550428 ENST00000551140 ENST00000551423 ENST00000552399
GeneID	2550
KEGG	hsa:2550
UCSC	uc003nmt.4 uc003nmu.4 uc011dls.1
CTD	2550
GeneCards	GC06M029523 GC06Mi29524 GC06Mj29520 GC06Mk29524 GC06Ml29523 GC06Mm29524 GC06Mn29524
HGNC	HGNC:4070
HPA	HPA050483
MIM	603540
neXtProt	NX_Q9UBS5
PharmGKB	PA28484
eggNOG	NOG273984
GeneTree	ENSGT00530000063129
HOVERGEN	HBG051688
InParanoid	Q9UBS5
KO	K04615
OMA	TGFTLAY
PhylomeDB	Q9UBS5
TreeFam	TF313965
Reactome	REACT_18319 REACT_19231 REACT_25004 REACT_25031 REACT_75831
ChiTaRS	GABBR1
GeneWiki	GABBR1
GenomeRNAi	2550
NextBio	10061
PRO	PR:Q9UBS5
Proteomes	UP000005640 UP000005640
Bgee	Q9UBS5
CleanEx	HS_GABBR1
ExpressionAtlas	Q9UBS5
Genevestigator	Q9UBS5
GO	GO:0030054 GO:0005737 GO:0030425 GO:0005576 GO:0038039 GO:0005887 GO:0005886 GO:0045211 GO:0042734 GO:0004965 GO:0007193 GO:0007214 GO:0007194 GO:0007268
InterPro	IPR001828 IPR002455 IPR017978 IPR002456 IPR028082 IPR000436
PANTHER	PTHR10519
Pfam	PF00003 PF01094 PF00084
PRINTS	PR01177
SMART	SM00032
SUPFAM	SSF53822 SSF57535
PROSITE	PS50259 PS50923

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0150099	neuron-glial cell signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0U4	P	has_start_location:(CL:0011005) has_end_location:(CL:0000127)	Seeded From UniProt	complete
part_of	GO:0038039	G protein-coupled receptor heterodimeric complex	PMID:9872316^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75899	C		Seeded From UniProt	complete
involved_in	GO:0007214	gamma-aminobutyric acid signaling pathway	PMID:9872316^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	PMID:10328880^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9872316^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004965	G protein-coupled GABA receptor activity	PMID:10328880^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0004965	G protein-coupled GABA receptor activity	PMID:9872316^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0038039	G protein-coupled receptor heterodimeric complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260446 PANTHER:PTN000828857 UniProtKB:A0A0B4LHR4 UniProtKB:O75899 UniProtKB:Q9UBS5	C		Seeded From UniProt	complete
involved_in	GO:0007214	gamma-aminobutyric acid signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260446 MGI:MGI:1860139 PANTHER:PTN000054983 RGD:619864 UniProtKB:A0A0B4LHR4 UniProtKB:O75899 UniProtKB:Q9UBS5 dictyBase:DDB_G0291356	P		Seeded From UniProt	complete
enables	GO:0004965	G protein-coupled GABA receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260446 PANTHER:PTN000054983 RGD:619864 RGD:621537 UniProtKB:A0A0B4LHR4 UniProtKB:O75899 UniProtKB:Q9UBS5 WB:WBGene00021528 WB:WBGene00022675 dictyBase:DDB_G0291356	F		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0099579	P		Seeded From UniProt	complete
enables	GO:0099579	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV18 ensembl:ENSMUSP00000025338	F		Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV18 ensembl:ENSMUSP00000025338	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV18 ensembl:ENSMUSP00000025338	C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV18 ensembl:ENSMUSP00000025338	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV18 ensembl:ENSMUSP00000025338	C		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV18 ensembl:ENSMUSP00000025338	C		Seeded From UniProt	complete
part_of	GO:0038037	G protein-coupled receptor dimeric complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV18 ensembl:ENSMUSP00000025338	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV18 ensembl:ENSMUSP00000025338	C		Seeded From UniProt	complete
involved_in	GO:0007214	gamma-aminobutyric acid signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV18 ensembl:ENSMUSP00000025338	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV18 ensembl:ENSMUSP00000025338	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017978	F		Seeded From UniProt	complete
enables	GO:0004965	G protein-coupled GABA receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002455 InterPro:IPR002456	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002455 InterPro:IPR002456 InterPro:IPR017978	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002455 InterPro:IPR002456 InterPro:IPR017978	C		Seeded From UniProt	complete
involved_in	GO:0007214	gamma-aminobutyric acid signaling pathway	PMID:9069281^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9753614^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004965	G protein-coupled GABA receptor activity	PMID:9069281^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-420688 Reactome:R-HSA-380073 Reactome:R-HSA-1013020	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 White, JH et al. (1998) Heterodimerization is required for the formation of a functional GABA(B) receptor. Nature 396 679-82 PubMed GONUTS page
↑ ^2.0 ^2.1 Martin, SC et al. (1999) Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1. Mol. Cell. Neurosci. 13 180-91 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Kaupmann, K et al. (1997) Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature 386 239-46 PubMed GONUTS page
↑ Grifa, A et al. (1998) GABA (gamma-amino-butyric acid) neurotransmission: identification and fine mapping of the human GABAB receptor gene. Biochem. Biophys. Res. Commun. 250 240-5 PubMed GONUTS page

[PMID:9872316-1] 1.0 ^1.1 ^1.2 ^1.3 White, JH et al. (1998) Heterodimerization is required for the formation of a functional GABA(B) receptor. Nature 396 679-82 PubMed GONUTS page

[PMID:10328880-2] 2.0 ^2.1 Martin, SC et al. (1999) Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1. Mol. Cell. Neurosci. 13 180-91 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9069281-4] 4.0 ^4.1 Kaupmann, K et al. (1997) Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature 386 239-46 PubMed GONUTS page

[PMID:9753614-5] Grifa, A et al. (1998) GABA (gamma-amino-butyric acid) neurotransmission: identification and fine mapping of the human GABAB receptor gene. Biochem. Biophys. Res. Commun. 250 240-5 PubMed GONUTS page

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HUMAN:GABR1

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