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HUMAN:FSHR

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FSHR (synonyms: LGR1)
Protein Name(s) Follicle-stimulating hormone receptor

FSH-R Follitropin receptor

External Links
UniProt P23945
EMBL M65085
M95489
S59900
JN003607
AY429104
AK292562
AC007189
AC079394
AC092533
CH471053
CH471053
BC096831
BC118548
BC125270
X68044
S73199
S73526
CCDS CCDS1843.1
CCDS1844.2
PIR I57661
RefSeq NP_000136.2
NP_852111.2
UniGene Hs.1428
PDB 1XUN
1XWD
4AY9
4MQW
PDBsum 1XUN
1XWD
4AY9
4MQW
ProteinModelPortal P23945
SMR P23945
BioGrid 108770
DIP DIP-35605N
IntAct P23945
MINT MINT-1177926
STRING 9606.ENSP00000384708
BindingDB P23945
ChEMBL CHEMBL2024
DrugBank DB00097
DB00066
DB00032
DB04786
DB00094
GuidetoPHARMACOLOGY 253
TCDB 9.A.14.1.5
PhosphoSite P23945
DMDM 311033420
PaxDb P23945
PRIDE P23945
Ensembl ENST00000304421
GeneID 2492
KEGG hsa:2492
UCSC uc002rww.3
uc002rwx.3
uc010fbn.3
CTD 2492
GeneCards GC02M049189
H-InvDB HIX0029905
HGNC HGNC:3969
MIM 136435
233300
608115
neXtProt NX_P23945
Orphanet 243
64739
619
PharmGKB PA28386
eggNOG NOG285844
GeneTree ENSGT00760000119088
HOGENOM HOG000045902
HOVERGEN HBG003521
InParanoid P23945
KO K04247
PhylomeDB P23945
TreeFam TF316814
Reactome REACT_16942
REACT_19327
SignaLink P23945
ChiTaRS FSHR
EvolutionaryTrace P23945
GeneWiki Follicle-stimulating_hormone_receptor
GenomeRNAi 2492
NextBio 35518027
PRO PR:P23945
Proteomes UP000005640
Bgee P23945
CleanEx HS_FSHR
ExpressionAtlas P23945
Genevestigator P23945
GO GO:0016021
GO:0005886
GO:0004963
GO:0007292
GO:0008585
GO:0042699
GO:0007186
GO:0008406
GO:0008584
GO:0007283
InterPro IPR002272
IPR024635
IPR000276
IPR017452
IPR002131
IPR001611
IPR000372
PANTHER PTHR24372
PTHR24372:SF5
Pfam PF00001
PF12369
PF13855
PF01462
PRINTS PR01143
PR00373
PR00237
SMART SM00013
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0016021

integral component of membrane

PMID:24692546[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

PMID:24692546[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042699

follicle-stimulating hormone signaling pathway

PMID:24692546[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004963

follicle-stimulating hormone receptor activity

PMID:24692546[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:24692546[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:24058690[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

PMID:24058690[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010738

regulation of protein kinase A signaling

PMID:24058690[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008584

male gonad development

PMID:17848411[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071372

cellular response to follicle-stimulating hormone stimulus

PMID:11847099[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004963

follicle-stimulating hormone receptor activity

PMID:11847099[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042699

follicle-stimulating hormone signaling pathway

PMID:11847099[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:11847099[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0009755

hormone-mediated signaling pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0016650
PANTHER:PTN001224574
RGD:3007

P

Seeded From UniProt

complete

enables

GO:0008528

G protein-coupled peptide receptor activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001224574
RGD:3007

F

Seeded From UniProt

complete

involved_in

GO:0007190

activation of adenylate cyclase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96783
PANTHER:PTN001224574
RGD:3007

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2153463
MGI:MGI:96783
MGI:MGI:98849
PANTHER:PTN001224574
RGD:1302973
RGD:2632
UniProtKB:Q90674

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003255
FB:FBgn0016650
MGI:MGI:96783
PANTHER:PTN001224574
RGD:3007
UniProtKB:O75473
UniProtKB:Q9BXB1

C

Seeded From UniProt

complete

enables

GO:0004963

follicle-stimulating hormone receptor activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95583
PANTHER:PTN001224579
RGD:2632
UniProtKB:P23945

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

enables

GO:0004963

follicle-stimulating hormone receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002272

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR002131
InterPro:IPR002272

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR002131
InterPro:IPR002272
InterPro:IPR017452

C

Seeded From UniProt

complete

enables

GO:0016500

protein-hormone receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002131

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:9020851[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008585

female gonad development

PMID:7553856[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008406

gonad development

PMID:9020851[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007292

female gamete generation

PMID:9020851[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

PMID:9020851[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-744887
Reactome:R-HSA-744886
Reactome:R-HSA-391378
Reactome:R-HSA-379044

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Jiang, X et al. (2014) Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer. J. Biol. Chem. 289 14273-82 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Uchida, S et al. (2013) Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome. PLoS ONE 8 e75478 PubMed GONUTS page
  3. ↑ O'Shaughnessy, PJ et al. (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. J. Clin. Endocrinol. Metab. 92 4792-801 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Costagliola, S et al. (2002) Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors. EMBO J. 21 504-13 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Tapanainen, JS et al. (1997) Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility. Nat. Genet. 15 205-6 PubMed GONUTS page
  7. ↑ Aittomäki, K et al. (1995) Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure. Cell 82 959-68 PubMed GONUTS page
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