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HUMAN:FSHB

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FSHB
Protein Name(s) Follitropin subunit beta

Follicle-stimulating hormone beta subunit FSH-B FSH-beta Follitropin beta chain

External Links
UniProt P01225
EMBL M16647
M16646
M24540
M24539
M54914
M54913
EF198021
EF585489
EF585490
EU081884
EU081885
AL358944
CH471064
BC113488
BC113490
CCDS CCDS7868.1
PIR A40920
RefSeq NP_000501.1
NP_001018090.1
UniGene Hs.36975
PDB 1FL7
1XWD
4AY9
4MQW
PDBsum 1FL7
1XWD
4AY9
4MQW
ProteinModelPortal P01225
SMR P01225
BioGrid 108766
DIP DIP-35604N
IntAct P01225
STRING 9606.ENSP00000254122
UniCarbKB P01225
DMDM 120552
PaxDb P01225
PeptideAtlas P01225
PRIDE P01225
DNASU 2488
Ensembl ENST00000254122
ENST00000417547
ENST00000533718
GeneID 2488
KEGG hsa:2488
UCSC uc001msl.3
CTD 2488
GeneCards GC11P030210
HGNC HGNC:3964
MIM 136530
229070
neXtProt NX_P01225
Orphanet 52901
PharmGKB PA28382
eggNOG NOG41629
GeneTree ENSGT00390000010115
HOGENOM HOG000116098
HOVERGEN HBG006698
InParanoid P01225
KO K05250
OMA TWCAGYC
OrthoDB EOG7JQBQF
PhylomeDB P01225
TreeFam TF332940
Reactome REACT_15398
REACT_16942
REACT_19327
EvolutionaryTrace P01225
GeneWiki FSHB
GenomeRNAi 2488
NextBio 9829
PRO PR:P01225
Proteomes UP000005640
Bgee P01225
CleanEx HS_FSHB
Genevestigator P01225
GO GO:0005737
GO:0005576
GO:0070062
GO:0005179
GO:0044267
GO:0007292
GO:0007565
GO:0042699
GO:0016486
GO:0045780
GO:0030335
GO:0008284
GO:0045944
GO:0006701
GO:0045670
GO:0060011
GO:0007165
GO:0007179
Gene3D 2.10.90.10
InterPro IPR029034
IPR006208
IPR001545
IPR018245
PANTHER PTHR11515
Pfam PF00007
SMART SM00068
SUPFAM SSF57501
PROSITE PS00261
PS00689

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0010893

positive regulation of steroid biosynthetic process

PMID:2494176[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016913

follicle-stimulating hormone activity

PMID:2494176[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016914

follicle-stimulating hormone complex

PMID:2494176[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:2494176[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:24692546[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0016913

follicle-stimulating hormone activity

PMID:11514332[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0016913

follicle-stimulating hormone activity

PMID:24692546[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

PMID:24692546[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016914

follicle-stimulating hormone complex

PMID:24692546[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:24692546[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20613903[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

has_regulation_target:(UniProtKB:P46531)

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

PMID:20613903[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:20613903[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:14557487[5]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:14602737[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:14718574[7]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042699

follicle-stimulating hormone signaling pathway

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95582
PANTHER:PTN000162094

P

Seeded From UniProt

complete

enables

GO:0016913

follicle-stimulating hormone activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000162094
UniProtKB:P01225

F

Seeded From UniProt

complete

involved_in

GO:0009755

hormone-mediated signaling pathway

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0063368
PANTHER:PTN000162063

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000162063
UniProtKB:P01225

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95582
MGI:MGI:96782
MGI:MGI:98848
PANTHER:PTN000162063
UniProtKB:P01225

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000162063
UniProtKB:P04651

C

Seeded From UniProt

complete

contributes_to

GO:0005179

hormone activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0063368
PANTHER:PTN000162063
UniProtKB:A6NKQ9
UniProtKB:P01223
UniProtKB:Q6NT52
ZFIN:ZDB-GENE-040806-1
ZFIN:ZDB-GENE-040806-2

F

Seeded From UniProt

complete

involved_in

GO:0060011

Sertoli cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60687
ensembl:ENSMUSP00000028533

P

Seeded From UniProt

complete

involved_in

GO:0045780

positive regulation of bone resorption

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60687
ensembl:ENSMUSP00000028533

P

Seeded From UniProt

complete

involved_in

GO:0045670

regulation of osteoclast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60687
ensembl:ENSMUSP00000028533

P

Seeded From UniProt

complete

involved_in

GO:0042699

follicle-stimulating hormone signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60687
ensembl:ENSMUSP00000028533

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60687
ensembl:ENSMUSP00000028533

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60687
ensembl:ENSMUSP00000028533

C

Seeded From UniProt

complete

involved_in

GO:0001541

ovarian follicle development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60687
ensembl:ENSMUSP00000028533

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001545
InterPro:IPR018245

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001545
InterPro:IPR018245

C

Seeded From UniProt

complete

involved_in

GO:0007565

female pregnancy

PMID:8220432[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007292

female gamete generation

PMID:8220432[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006701

progesterone biosynthetic process

PMID:14557487[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016486

peptide hormone processing

Reactome:R-HSA-209952

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-744887
Reactome:R-HSA-744886
Reactome:R-HSA-391378
Reactome:R-HSA-379044
Reactome:R-HSA-378975

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Keene, JL et al. (1989) Expression of biologically active human follitropin in Chinese hamster ovary cells. J. Biol. Chem. 264 4769-75 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Jiang, X et al. (2014) Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer. J. Biol. Chem. 289 14273-82 PubMed GONUTS page
  3. ↑ Kumar, RS et al. (2001) Molecular biology of the channel catfish gonadotropin receptors: 2. Complementary DNA cloning, functional expression, and seasonal gene expression of the follicle-stimulating hormone receptor. Biol. Reprod. 65 710-7 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Park, YH et al. (2010) Follicular stimulating hormone enhances Notch 1 expression in SK-OV-3 ovarian cancer cells. J Gynecol Oncol 21 119-24 PubMed GONUTS page
  5. ↑ 5.0 5.1 Liu, J et al. (2003) Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells. J. Clin. Endocrinol. Metab. 88 5002-8 PubMed GONUTS page
  6. ↑ Zhang, X et al. (2003) A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells. J. Clin. Endocrinol. Metab. 88 5119-26 PubMed GONUTS page
  7. ↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  9. ↑ 9.0 9.1 Matthews, CH et al. (1993) Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone. Nat. Genet. 5 83-6 PubMed GONUTS page
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