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HUMAN:FRIL

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FTL
Protein Name(s) Ferritin light chain

Ferritin L subunit

External Links
UniProt P02792
EMBL M11147
M10119
M12938
AY207005
CR456715
AK311773
BX571748
AC026803
BC002991
BC004245
BC008439
BC013928
BC016715
BC016346
BC016354
BC018990
BC021670
BC058820
BC062708
X03742
X03743
X03743
CCDS CCDS33070.1
PIR B23920
RefSeq NP_000137.2
UniGene Hs.433670
Hs.728304
PDB 2FFX
2FG4
2FG8
3HX2
3HX5
3HX7
3KXU
PDBsum 2FFX
2FG4
2FG8
3HX2
3HX5
3HX7
3KXU
ProteinModelPortal P02792
SMR P02792
BioGrid 108789
DIP DIP-31248N
IntAct P02792
MINT MINT-1187221
STRING 9606.ENSP00000366525
DrugBank DB00893
PhosphoSite P02792
DMDM 120523
MaxQB P02792
PaxDb P02792
PRIDE P02792
DNASU 2512
Ensembl ENST00000331825
GeneID 2512
KEGG hsa:2512
UCSC uc002plo.3
CTD 2512
GeneCards GC19P049468
GeneReviews FTL
HGNC HGNC:3999
HPA CAB020769
HPA041602
MIM 134790
600886
606159
615604
neXtProt NX_P02792
Orphanet 254704
163
157846
PharmGKB PA28412
eggNOG NOG321513
GeneTree ENSGT00760000119129
HOVERGEN HBG000410
InParanoid P02792
KO K13625
OMA CDYLERE
OrthoDB EOG7DRJ49
PhylomeDB P02792
TreeFam TF313885
Reactome REACT_163699
REACT_19400
REACT_25060
ChiTaRS FTL
EvolutionaryTrace P02792
GeneWiki Ferritin_light_chain
GenomeRNAi 2512
NextBio 9899
PRO PR:P02792
Proteomes UP000005640
Bgee P02792
CleanEx HS_FTL
ExpressionAtlas P02792
Genevestigator P02792
GO GO:0005829
GO:0070062
GO:0008043
GO:0016020
GO:0008199
GO:0042802
GO:0005506
GO:0006879
GO:0055072
GO:0006826
GO:0061024
GO:0006892
GO:0055085
Gene3D 1.20.1260.10
InterPro IPR001519
IPR009040
IPR009078
IPR012347
IPR014034
IPR008331
PANTHER PTHR11431
Pfam PF00210
SUPFAM SSF47240
PROSITE PS00540
PS00204
PS50905

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070062

extracellular exosome

PMID:23533145[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0008043

intracellular ferritin complex

PMID:20159981[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0008043

intracellular ferritin complex

PMID:19923220[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

PMID:20159981[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

PMID:19923220[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10921
PANTHER:PTN000153092
UniProtKB:P02792
WB:WBGene00001500
WB:WBGene00001501

F

Seeded From UniProt

complete

enables

GO:0008199

ferric iron binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10921
PANTHER:PTN000153092

F

Seeded From UniProt

complete

enables

GO:0008198

ferrous iron binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000153092
UniProtKB:A0A0B4KHF0
UniProtKB:A0A0B4KI27

F

Seeded From UniProt

complete

involved_in

GO:0006880

intracellular sequestering of iron ion

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10921
PANTHER:PTN000153092
UniProtKB:P02794
UniProtKB:P9WNE5

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000153092
RGD:61813

C

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95588
PANTHER:PTN000153092
UniProtKB:P02792

F

Seeded From UniProt

complete

enables

GO:0004322

ferroxidase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10921
PANTHER:PTN000153092
UniProtKB:P9WNE5

F

Seeded From UniProt

complete

part_of

GO:0044754

autolysosome

PMID:25327288[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25910212[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02792

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25416956[9]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02792

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16790936[10]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02792

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16189514[11]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02792

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16169070[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02792

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004322

P

Seeded From UniProt

complete

involved_in

GO:0006826

iron ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001519

P

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001519
InterPro:IPR008331

P

Seeded From UniProt

complete

enables

GO:0008199

ferric iron binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001519
InterPro:IPR008331

F

Seeded From UniProt

complete

part_of

GO:0008043

intracellular ferritin complex

PMID:7492760[13]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

PMID:7492760[13]
Reactome:R-HSA-917937

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

PMID:7493028[14]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0055072

iron ion homeostasis

PMID:19923220[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0035578

azurophil granule lumen

Reactome:R-HSA-6798751

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-434362
Reactome:R-HSA-1562626

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6798751

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0409

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  2. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  3. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  4. ↑ 4.0 4.1 Luscieti, S et al. (2010) Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation. J. Biol. Chem. 285 11948-57 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Baraibar, MA et al. (2010) Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration. J. Biol. Chem. 285 1950-6 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ Dowdle, WE et al. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16 1069-79 PubMed GONUTS page
  8. ↑ Sahni, N et al. (2015) Widespread macromolecular interaction perturbations in human genetic disorders. Cell 161 647-660 PubMed GONUTS page
  9. ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
  10. ↑ Wang, Z et al. (2006) Structure of human ferritin L chain. Acta Crystallogr. D Biol. Crystallogr. 62 800-6 PubMed GONUTS page
  11. ↑ Rual, JF et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437 1173-8 PubMed GONUTS page
  12. ↑ Stelzl, U et al. (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell 122 957-68 PubMed GONUTS page
  13. ↑ 13.0 13.1 Girelli, D et al. (1995) Molecular basis for the recently described hereditary hyperferritinemia-cataract syndrome: a mutation in the iron-responsive element of ferritin L-subunit gene (the "Verona mutation") Blood 86 4050-3 PubMed GONUTS page
  14. ↑ Beaumont, C et al. (1995) Mutation in the iron responsive element of the L ferritin mRNA in a family with dominant hyperferritinaemia and cataract. Nat. Genet. 11 444-6 PubMed GONUTS page
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