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HUMAN:FOLC

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FPGS
Protein Name(s) Folylpolyglutamate synthase, mitochondrial

Folylpoly-gamma-glutamate synthetase FPGS Tetrahydrofolylpolyglutamate synthase Tetrahydrofolate synthase

External Links
UniProt Q05932
EMBL AK056920
AK295309
AL162586
AL162586
BC064393
AH006037
M98045
U14939
AH003340
CCDS CCDS35148.1
CCDS35149.1
CCDS75905.1
PIR A46281
RefSeq NP_001018088.1
NP_001275732.1
NP_004948.4
UniGene Hs.335084
ProteinModelPortal Q05932
SMR Q05932
BioGrid 108639
STRING 9606.ENSP00000362344
BindingDB Q05932
ChEMBL CHEMBL3171
DrugBank DB00563
DB06813
DB00293
PhosphoSite Q05932
DMDM 1706884
MaxQB Q05932
PaxDb Q05932
PRIDE Q05932
DNASU 2356
Ensembl ENST00000373225
ENST00000373247
ENST00000393706
GeneID 2356
KEGG hsa:2356
UCSC uc004bsg.1
uc011mal.1
CTD 2356
GeneCards GC09P130556
HGNC HGNC:3824
HPA HPA050488
MIM 136510
neXtProt NX_Q05932
PharmGKB PA167
eggNOG COG0285
GeneTree ENSGT00390000016526
HOGENOM HOG000181278
HOVERGEN HBG003086
InParanoid Q05932
KO K01930
OMA WNHLDEE
OrthoDB EOG7T7GTN
PhylomeDB Q05932
TreeFam TF313956
BioCyc MetaCyc:HS06237-MONOMER
Reactome REACT_11167
UniPathway UPA00850
ChiTaRS FPGS
GeneWiki FPGS
GenomeRNAi 2356
NextBio 9555
PRO PR:Q05932
Proteomes UP000005640
Bgee Q05932
CleanEx HS_FPGS
ExpressionAtlas Q05932
Genevestigator Q05932
GO GO:0005737
GO:0005829
GO:0005743
GO:0005759
GO:0005739
GO:0005524
GO:0004326
GO:0007420
GO:0046655
GO:0001889
GO:0006139
GO:0006730
GO:0031100
GO:0044281
GO:0006766
GO:0006767
Gene3D 3.40.1190.10
3.90.190.20
InterPro IPR001645
IPR018109
IPR023600
IPR004101
IPR013221
PANTHER PTHR11136
PIRSF PIRSF038895
SUPFAM SSF53244
SSF53623
TIGRFAMs TIGR01499
PROSITE PS01011
PS01012

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006536

glutamate metabolic process

PMID:3619447[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006760

folic acid-containing compound metabolic process

PMID:3619447[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046901

tetrahydrofolylpolyglutamate biosynthetic process

PMID:3619447[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004326

tetrahydrofolylpolyglutamate synthase activity

PMID:3619447[1]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(CHEBI:44185)|has_direct_input:(CHEBI:27470)|has_direct_input:(CHEBI:22526)

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000123999
TAIR:locus:2100048

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10327
PANTHER:PTN000123998
SGD:S000005767
UniProtKB:A0A1D8PQV5

C

Seeded From UniProt

complete

enables

GO:0004326

tetrahydrofolylpolyglutamate synthase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10327
PANTHER:PTN000123998
RGD:1587713
SGD:S000005767
TAIR:locus:2078936
TAIR:locus:2100048
TAIR:locus:2153639
UniProtKB:Q05932
UniProtKB:Q8IE69

F

Seeded From UniProt

complete

involved_in

GO:0031100

animal organ regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:M0R401
ensembl:ENSRNOP00000064076

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:M0R401
ensembl:ENSRNOP00000064076

P

Seeded From UniProt

complete

enables

GO:0004326

tetrahydrofolylpolyglutamate synthase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:M0R401
ensembl:ENSRNOP00000064076

F

Seeded From UniProt

complete

involved_in

GO:0001889

liver development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:M0R401
ensembl:ENSRNOP00000064076

P

Seeded From UniProt

complete

enables

GO:0004326

tetrahydrofolylpolyglutamate synthase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001645
InterPro:IPR018109
InterPro:IPR023600

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001645
InterPro:IPR018109
InterPro:IPR023600
InterPro:IPR036565
InterPro:IPR036615

F

Seeded From UniProt

complete

involved_in

GO:0009058

biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR036565
InterPro:IPR036615

P

Seeded From UniProt

complete

involved_in

GO:0009396

folic acid-containing compound biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001645
InterPro:IPR018109
InterPro:IPR023600

P

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR036615

F

Seeded From UniProt

complete

enables

GO:0004326

tetrahydrofolylpolyglutamate synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:6.3.2.17

F

Seeded From UniProt

complete

involved_in

GO:0046901

tetrahydrofolylpolyglutamate biosynthetic process

PMID:25164808[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:25164808[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008283

cell population proliferation

PMID:25164808[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004326

tetrahydrofolylpolyglutamate synthase activity

PMID:25164808[3]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(CHEBI:15640)

Seeded From UniProt

complete

involved_in

GO:0046901

tetrahydrofolylpolyglutamate biosynthetic process

PMID:25164808[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004326

tetrahydrofolylpolyglutamate synthase activity

PMID:25164808[3]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(CHEBI:15640)

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:25164808[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008283

cell population proliferation

PMID:25164808[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006139

nucleobase-containing compound metabolic process

PMID:7721888[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:7721888[4]
Reactome:R-HSA-200681
Reactome:R-HSA-197958

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:7721888[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:1409616[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004326

tetrahydrofolylpolyglutamate synthase activity

PMID:7721888[4]
Reactome:R-HSA-200682
Reactome:R-HSA-200681
Reactome:R-HSA-197958

ECO:0000304

author statement supported by traceable reference used in manual assertion




F

Seeded From UniProt

complete

involved_in

GO:0046655

folic acid metabolic process

Reactome:R-HSA-196757

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

Reactome:R-HSA-200682

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006730

one-carbon metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0554

P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0999
UniProtKB-SubCell:SL-0168

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

involved_in

GO:0046901

tetrahydrofolylpolyglutamate biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00850

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Clarke, L & Waxman, DJ (1987) Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists. Arch. Biochem. Biophys. 256 585-96 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Lawrence, SA et al. (2014) Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates. J. Biol. Chem. 289 29386-96 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Freemantle, SJ et al. (1995) Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene. J. Biol. Chem. 270 9579-84 PubMed GONUTS page
  5. ↑ Garrow, TA et al. (1992) Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure. Proc. Natl. Acad. Sci. U.S.A. 89 9151-5 PubMed GONUTS page
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