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HUMAN:FMO3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | FMO3 | |
| Protein Name(s) | Dimethylaniline monooxygenase [N-oxide-forming] 3
Dimethylaniline oxidase 3 FMO II FMO form 2 Hepatic flavin-containing monooxygenase 3 FMO 3 Trimethylamine monooxygenase | |
| External Links | ||
| UniProt | P31513 | |
| EMBL | M83772 Z47552 U39967 U39961 U39962 U39963 U39964 U39965 U39966 AY895830 AK313197 AL021026 CH471067 BC032016 | |
| CCDS | CCDS1292.1 | |
| PIR | A38228 S62367 | |
| RefSeq | NP_001002294.1 NP_008825.4 | |
| UniGene | Hs.445350 | |
| ProteinModelPortal | P31513 | |
| SMR | P31513 | |
| STRING | 9606.ENSP00000356729 | |
| DrugBank | DB00918 DB00501 DB00363 DB00250 DB01254 DB00334 DB00675 DB05294 DB00582 | |
| PhosphoSite | P31513 | |
| DMDM | 6166183 | |
| PaxDb | P31513 | |
| PRIDE | P31513 | |
| DNASU | 2328 | |
| Ensembl | ENST00000367755 | |
| GeneID | 2328 | |
| KEGG | hsa:2328 | |
| UCSC | uc001ghh.3 | |
| CTD | 2328 | |
| GeneCards | GC01P171060 | |
| GeneReviews | FMO3 | |
| HGNC | HGNC:3771 | |
| HPA | HPA008065 HPA013750 | |
| MIM | 136132 602079 | |
| neXtProt | NX_P31513 | |
| Orphanet | 35056 | |
| PharmGKB | PA166 | |
| eggNOG | COG2072 | |
| GeneTree | ENSGT00760000119232 | |
| HOGENOM | HOG000076537 | |
| HOVERGEN | HBG002037 | |
| InParanoid | P31513 | |
| KO | K00485 | |
| OMA | FMHNSKL | |
| OrthoDB | EOG7GXPB6 | |
| PhylomeDB | P31513 | |
| TreeFam | TF105285 | |
| BioCyc | MetaCyc:HS00223-MONOMER | |
| Reactome | REACT_13653 | |
| SABIO-RK | P31513 | |
| GeneWiki | Flavin_containing_monooxygenase_3 | |
| GenomeRNAi | 2328 | |
| NextBio | 9447 | |
| PRO | PR:P31513 | |
| Proteomes | UP000005640 | |
| Bgee | P31513 | |
| CleanEx | HS_FMO3 | |
| ExpressionAtlas | P31513 | |
| Genevestigator | P31513 | |
| GO | GO:0005789 GO:0016021 GO:0043231 GO:0016597 GO:0050660 GO:0004499 GO:0050661 GO:0034899 GO:0017144 GO:0044281 GO:0006805 | |
| InterPro | IPR012143 IPR000960 IPR020946 IPR002255 | |
| Pfam | PF00743 | |
| PIRSF | PIRSF000332 | |
| PRINTS | PR00370 PR01123 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1310002 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004499 |
N,N-dimethylaniline monooxygenase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050660 |
flavin adenine dinucleotide binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050661 |
NADP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004499 |
N,N-dimethylaniline monooxygenase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034899 |
trimethylamine monooxygenase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0055114 |
oxidation-reduction process |
ECO:0000314 |
P |
Figure 2. Alignment of the amino acid sequences of FMOs of various acrtiid species |
complete | |||||
|
involved_in |
GO:0006805 |
xenobiotic metabolic process |
Reactome:R-HSA-211945 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
Reactome:R-HSA-139970 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031090 |
organelle membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Chung, WG & Cha, YN (1997) Oxidation of caffeine to theobromine and theophylline is catalyzed primarily by flavin-containing monooxygenase in liver microsomes. Biochem. Biophys. Res. Commun. 235 685-8 PubMed GONUTS page
- ↑ Sehlmeyer, S et al. (2010) Flavin-dependent monooxygenases as a detoxification mechanism in insects: new insights from the arctiids (lepidoptera). PLoS ONE 5 e10435 PubMed GONUTS page
