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HUMAN:FGF21

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FGF21
Protein Name(s) Fibroblast growth factor 21

FGF-21

External Links
UniProt Q9NSA1
EMBL AB021975
AY359086
DQ847413
CH471177
BC018404
CCDS CCDS12734.1
RefSeq NP_061986.1
XP_005258788.1
UniGene Hs.283015
ProteinModelPortal Q9NSA1
SMR Q9NSA1
BioGrid 117672
IntAct Q9NSA1
MINT MINT-6799873
STRING 9606.ENSP00000222157
DMDM 13626703
PaxDb Q9NSA1
PRIDE Q9NSA1
DNASU 26291
Ensembl ENST00000222157
ENST00000593756
GeneID 26291
KEGG hsa:26291
UCSC uc002pkn.1
CTD 26291
GeneCards GC19P049259
HGNC HGNC:3678
HPA HPA061286
MIM 609436
neXtProt NX_Q9NSA1
PharmGKB PA28117
eggNOG NOG311125
GeneTree ENSGT00530000063469
HOGENOM HOG000112572
HOVERGEN HBG051612
InParanoid Q9NSA1
KO K04358
OMA TLYGSLH
OrthoDB EOG7X6M1F
PhylomeDB Q9NSA1
TreeFam TF335872
GeneWiki FGF21
GenomeRNAi 26291
NextBio 48635
PRO PR:Q9NSA1
Proteomes UP000005640
Bgee Q9NSA1
CleanEx HS_FGF21
Genevestigator Q9NSA1
GO GO:0005576
GO:0007267
GO:0008284
GO:0070374
GO:0046326
GO:0045716
GO:0090080
GO:0010988
GO:0007165
InterPro IPR008996
IPR028292
IPR002209
IPR028142
PANTHER PTHR11486
PTHR11486:SF62
PRINTS PR00263
PR00262
SMART SM00442
SUPFAM SSF50353
PROSITE PS00247

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

PMID:22302939[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9JJN1

P

Seeded From UniProt

complete

involved_in

GO:0045716

positive regulation of low-density lipoprotein particle receptor biosynthetic process

PMID:22378787[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010988

regulation of low-density lipoprotein particle clearance

PMID:22378787[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:17623664[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046326

positive regulation of glucose import

PMID:17623664[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005623

cell

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0071333

C

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:2000352

negative regulation of endothelial cell apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8VI80
ensembl:ENSRNOP00000028490

P

Seeded From UniProt

complete

involved_in

GO:1904640

response to methionine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8VI80
ensembl:ENSRNOP00000028490

P

Seeded From UniProt

complete

involved_in

GO:1901215

negative regulation of neuron death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8VI80
ensembl:ENSRNOP00000028490

P

Seeded From UniProt

complete

involved_in

GO:0072577

endothelial cell apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8VI80
ensembl:ENSRNOP00000028490

P

Seeded From UniProt

complete

involved_in

GO:0071404

cellular response to low-density lipoprotein particle stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8VI80
ensembl:ENSRNOP00000028490

P

Seeded From UniProt

complete

involved_in

GO:0071377

cellular response to glucagon stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8VI80
ensembl:ENSRNOP00000028490

P

Seeded From UniProt

complete

involved_in

GO:0071333

cellular response to glucose stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8VI80
ensembl:ENSRNOP00000028490

P

Seeded From UniProt

complete

involved_in

GO:0035690

cellular response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8VI80
ensembl:ENSRNOP00000028490

P

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8VI80
ensembl:ENSRNOP00000028490

P

Seeded From UniProt

complete

involved_in

GO:0030968

endoplasmic reticulum unfolded protein response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8VI80
ensembl:ENSRNOP00000028490

P

Seeded From UniProt

complete

involved_in

GO:0014823

response to activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8VI80
ensembl:ENSRNOP00000028490

P

Seeded From UniProt

complete

involved_in

GO:0010898

positive regulation of triglyceride catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8VI80
ensembl:ENSRNOP00000028490

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8VI80
ensembl:ENSRNOP00000028490

C

Seeded From UniProt

complete

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJN1
ensembl:ENSMUSP00000033099

P

Seeded From UniProt

complete

involved_in

GO:0090080

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJN1
ensembl:ENSMUSP00000033099

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJN1
ensembl:ENSMUSP00000033099

P

Seeded From UniProt

complete

enables

GO:0005104

fibroblast growth factor receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028292
InterPro:IPR035444

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028292
InterPro:IPR035444

C

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002209

F

Seeded From UniProt

complete

involved_in

GO:0008543

fibroblast growth factor receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028292
InterPro:IPR035444

P

Seeded From UniProt

complete

involved_in

GO:0007267

cell-cell signaling

PMID:10858549[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:10858549[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:10858549[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Fisher, FM et al. (2012) FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 26 271-81 PubMed GONUTS page
  2. ↑ 2.0 2.1 Do, HT et al. (2012) Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap). J. Biol. Chem. 287 12602-11 PubMed GONUTS page
  3. ↑ 3.0 3.1 Kurosu, H et al. (2007) Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J. Biol. Chem. 282 26687-95 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Nishimura, T et al. (2000) Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim. Biophys. Acta 1492 203-6 PubMed GONUTS page
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