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HUMAN:FGF19

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FGF19
Protein Name(s) Fibroblast growth factor 19

FGF-19

External Links
UniProt O95750
EMBL AB018122
AF110400
AY358302
BT006729
BC017664
CCDS CCDS8193.1
RefSeq NP_005108.1
UniGene Hs.249200
PDB 1PWA
2P23
PDBsum 1PWA
2P23
ProteinModelPortal O95750
SMR O95750
BioGrid 115290
DIP DIP-6039N
STRING 9606.ENSP00000294312
PhosphoSite O95750
PaxDb O95750
PRIDE O95750
DNASU 9965
Ensembl ENST00000294312
GeneID 9965
KEGG hsa:9965
UCSC uc001opf.3
CTD 9965
GeneCards GC11M069513
HGNC HGNC:3675
HPA HPA036082
MIM 603891
neXtProt NX_O95750
PharmGKB PA28114
eggNOG NOG294039
GeneTree ENSGT00530000063469
HOGENOM HOG000112572
HOVERGEN HBG051611
InParanoid O95750
KO K04358
OMA SEEDCAF
OrthoDB EOG7BS4C1
PhylomeDB O95750
TreeFam TF335872
Reactome REACT_111046
REACT_111184
REACT_147727
REACT_21247
REACT_21270
REACT_21310
REACT_21374
REACT_75829
REACT_9452
REACT_976
EvolutionaryTrace O95750
GeneWiki FGF19
GenomeRNAi 9965
NextBio 37606
PRO PR:O95750
Proteomes UP000005640
Bgee O95750
CleanEx HS_FGF19
Genevestigator O95750
GO GO:0005576
GO:0005104
GO:0007173
GO:0038095
GO:0008543
GO:0007507
GO:0045087
GO:0008286
GO:0070858
GO:0007399
GO:0001755
GO:0048011
GO:0048015
GO:0008284
GO:0070374
GO:0046326
GO:0046330
InterPro IPR008996
IPR028303
IPR002209
IPR028142
PANTHER PTHR11486
PTHR11486:SF74
PRINTS PR00263
PR00262
SMART SM00442
SUPFAM SSF50353
PROSITE PS00247

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:19085950[1]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0000182)

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

PMID:17627937[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_input:(UniProtKB:Q8WU20)|has_input:(UniProtKB:P27361)|has_input:(UniProtKB:P28482)

Seeded From UniProt

complete

enables

GO:0005104

fibroblast growth factor receptor binding

PMID:17627937[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P22455

F

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:19085950[1]

ECO:0000314

direct assay evidence used in manual assertion

P

has_input:(UniProtKB:P22680)|occurs_in(CL:0000182)

Seeded From UniProt

complete

involved_in

GO:0070858

negative regulation of bile acid biosynthetic process

PMID:12815072[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:17623664[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046330

positive regulation of JNK cascade

PMID:12815072[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046326

positive regulation of glucose import

PMID:17623664[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005104

fibroblast growth factor receptor binding

PMID:10525310[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P22455

F

Seeded From UniProt

complete

involved_in

GO:0008543

fibroblast growth factor receptor signaling pathway

PMID:10525310[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P22455

P

Seeded From UniProt

complete

involved_in

GO:0008543

fibroblast growth factor receptor signaling pathway

PMID:18187602[6]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q61851

P

Seeded From UniProt

complete

involved_in

GO:0008543

fibroblast growth factor receptor signaling pathway

PMID:18187602[6]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q03142

P

Seeded From UniProt

complete

involved_in

GO:0008543

fibroblast growth factor receptor signaling pathway

PMID:18187602[6]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P21803

P

Seeded From UniProt

complete

involved_in

GO:0008543

fibroblast growth factor receptor signaling pathway

PMID:18187602[6]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P16092

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:18187602[6]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q61851

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:18187602[6]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q03142

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:18187602[6]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P21803

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:18187602[6]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P16092

P

Seeded From UniProt

complete

enables

GO:0005104

fibroblast growth factor receptor binding

PMID:10525310[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P22455

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

enables

GO:0005104

fibroblast growth factor receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028303
InterPro:IPR035444

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028303
InterPro:IPR035444

C

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002209

F

Seeded From UniProt

complete

involved_in

GO:0008543

fibroblast growth factor receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028303
InterPro:IPR035444

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

PMID:9931477[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051897

positive regulation of protein kinase B signaling

Reactome:R-HSA-2316434

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008543

fibroblast growth factor receptor signaling pathway

Reactome:R-HSA-5654743
Reactome:R-HSA-190322

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-5672965
Reactome:R-HSA-5654734
Reactome:R-HSA-5654717
Reactome:R-HSA-5654714
Reactome:R-HSA-5654684
Reactome:R-HSA-5654669
Reactome:R-HSA-5654667
Reactome:R-HSA-5654664
Reactome:R-HSA-5654663
Reactome:R-HSA-5654662
Reactome:R-HSA-5654659
Reactome:R-HSA-5654658
Reactome:R-HSA-5654655
Reactome:R-HSA-5654653
Reactome:R-HSA-5654651
Reactome:R-HSA-5654566
Reactome:R-HSA-5654428
Reactome:R-HSA-5654426
Reactome:R-HSA-5654425
Reactome:R-HSA-5654423
Reactome:R-HSA-5654422
Reactome:R-HSA-5654418
Reactome:R-HSA-5654169
Reactome:R-HSA-5654163
Reactome:R-HSA-5654151
Reactome:R-HSA-2400009
Reactome:R-HSA-2316434
Reactome:R-HSA-190326
Reactome:R-HSA-190265
Reactome:R-HSA-1307963
Reactome:R-HSA-1307955
Reactome:R-HSA-109699

ECO:0000304

author statement supported by traceable reference used in manual assertion
































C

Seeded From UniProt

complete

involved_in

GO:0000165

MAPK cascade

Reactome:R-HSA-5673001

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Song, KH et al. (2009) Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. Hepatology 49 297-305 PubMed GONUTS page
  2. ↑ 2.0 2.1 Lin, BC et al. (2007) Liver-specific activities of FGF19 require Klotho beta. J. Biol. Chem. 282 27277-84 PubMed GONUTS page
  3. ↑ 3.0 3.1 Holt, JA et al. (2003) Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev. 17 1581-91 PubMed GONUTS page
  4. ↑ 4.0 4.1 Kurosu, H et al. (2007) Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J. Biol. Chem. 282 26687-95 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Xie, MH et al. (1999) FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. Cytokine 11 729-35 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Suzuki, M et al. (2008) betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol. Endocrinol. 22 1006-14 PubMed GONUTS page
  7. ↑ Nishimura, T et al. (1999) Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. Biochim. Biophys. Acta 1444 148-51 PubMed GONUTS page
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