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HUMAN:FCG3A
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | FCGR3A (synonyms: CD16A, FCG3, FCGR3, IGFR3) | |
| Protein Name(s) | Low affinity immunoglobulin gamma Fc region receptor III-A
CD16a antigen Fc-gamma RIII-alpha Fc-gamma RIII Fc-gamma RIIIa FcRIII FcRIIIa FcR-10 IgG Fc receptor III-2 | |
| External Links | ||
| UniProt | P08637 | |
| EMBL | X52645 AK223268 AK223295 AL590385 BC017865 BC033678 Z46222 S76824 M24853 | |
| CCDS | CCDS44266.1 | |
| PIR | JL0107 | |
| RefSeq | NP_000560.5 NP_001121064.1 NP_001121065.1 NP_001121067.1 NP_001121068.1 | |
| UniGene | Hs.372679 | |
| PDB | 3AY4 3SGJ 3SGK | |
| PDBsum | 3AY4 3SGJ 3SGK | |
| ProteinModelPortal | P08637 | |
| SMR | P08637 | |
| BioGrid | 108508 | |
| IntAct | P08637 | |
| STRING | 9606.ENSP00000356946 | |
| DrugBank | DB00054 DB00051 DB00092 DB00087 DB00074 DB00112 DB00002 DB00111 DB00095 DB00005 DB00056 DB00078 DB00028 DB00075 DB00108 DB00110 DB00073 DB00081 DB00072 | |
| MEROPS | I43.001 | |
| PhosphoSite | P08637 | |
| DMDM | 119876 | |
| PaxDb | P08637 | |
| PRIDE | P08637 | |
| DNASU | 2214 | |
| Ensembl | ENST00000367967 ENST00000436743 ENST00000443193 | |
| GeneID | 2214 | |
| KEGG | hsa:2214 | |
| UCSC | uc001gar.3 | |
| CTD | 2214 | |
| GeneCards | GC01M161511 | |
| HGNC | HGNC:3619 | |
| HPA | CAB032435 HPA055431 | |
| MIM | 146740 615707 | |
| neXtProt | NX_P08637 | |
| PharmGKB | PA28065 | |
| eggNOG | NOG47725 | |
| GeneTree | ENSGT00760000119130 | |
| HOVERGEN | HBG051602 | |
| InParanoid | P08637 | |
| KO | K06463 | |
| PhylomeDB | P08637 | |
| Reactome | REACT_11152 REACT_160086 REACT_160158 REACT_160274 | |
| ChiTaRS | FCGR3A | |
| EvolutionaryTrace | P08637 | |
| GeneWiki | FCGR3A | |
| GenomeRNAi | 2214 | |
| NextBio | 8979 | |
| PRO | PR:P08637 | |
| Proteomes | UP000005640 | |
| Bgee | P08637 | |
| CleanEx | HS_FCGR3A | |
| ExpressionAtlas | P08637 | |
| Genevestigator | P08637 | |
| GO | GO:0009897 GO:0070062 GO:0016021 GO:0005886 GO:0038096 GO:0006955 GO:0045087 GO:0050776 | |
| Gene3D | 2.60.40.10 | |
| InterPro | IPR007110 IPR013783 IPR003599 | |
| SMART | SM00409 | |
| PROSITE | PS50835 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0042269 |
regulation of natural killer cell mediated cytotoxicity |
ECO:0000314 |
P |
Fig. 2 shows the results of a direct assay to show that FcR activates during the process of cytotoxicity. |
complete | |||||
|
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000094) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006955 |
immune response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
PMID:2138330[5] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0050776 |
regulation of immune response |
Reactome:R-HSA-198933 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0038096 |
Fc-gamma receptor signaling pathway involved in phagocytosis |
Reactome:R-HSA-2029480 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019864 |
IgG binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Einspahr, KJ et al. (1991) Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function. Proc. Natl. Acad. Sci. U.S.A. 88 6279-83 PubMed GONUTS page
- ↑ Zhen, A et al. (2014) CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection. J. Virol. 88 9934-46 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Lee, SC et al. (2000) Cutaneous injection of human subjects with macrophage inflammatory protein-1 alpha induces significant recruitment of neutrophils and monocytes. J. Immunol. 164 3392-401 PubMed GONUTS page
- ↑ 5.0 5.1 Anderson, P et al. (1990) Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells. Proc. Natl. Acad. Sci. U.S.A. 87 2274-8 PubMed GONUTS page
