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HUMAN:FABPH

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FABP3 (synonyms: FABP11, MDGI)
Protein Name(s) Fatty acid-binding protein, heart

Fatty acid-binding protein 3 Heart-type fatty acid-binding protein H-FABP Mammary-derived growth inhibitor MDGI Muscle fatty acid-binding protein M-FABP

External Links
UniProt P05413
EMBL X56549
Y10255
U57623
AK314122
U17081
S67314
BT006727
AL451070
CH471059
BC007021
CCDS CCDS342.1
PIR S15432
RefSeq NP_004093.1
UniGene Hs.657242
PDB 1G5W
1HMR
1HMS
1HMT
2HMB
3RSW
3WBG
3WXQ
PDBsum 1G5W
1HMR
1HMS
1HMT
2HMB
3RSW
3WBG
3WXQ
ProteinModelPortal P05413
SMR P05413
BioGrid 108468
IntAct P05413
MINT MINT-1432076
STRING 9606.ENSP00000362817
BindingDB P05413
ChEMBL CHEMBL3344
PhosphoSite P05413
DMDM 119802
REPRODUCTION-2DPAGE IPI00219684
UCD-2DPAGE P05413
MaxQB P05413
PaxDb P05413
PeptideAtlas P05413
PRIDE P05413
DNASU 2170
Ensembl ENST00000373713
GeneID 2170
KEGG hsa:2170
UCSC uc001bss.1
CTD 2170
GeneCards GC01M031838
HGNC HGNC:3557
HPA CAB017830
HPA055754
MIM 134651
neXtProt NX_P05413
PharmGKB PA27958
eggNOG NOG281572
GeneTree ENSGT00760000118898
HOGENOM HOG000004829
HOVERGEN HBG005633
InParanoid P05413
KO K08752
OMA CTRRYEK
OrthoDB EOG7NW6BZ
PhylomeDB P05413
TreeFam TF316894
ChiTaRS FABP3
EvolutionaryTrace P05413
GeneWiki Heart-type_fatty_acid_binding_protein
GenomeRNAi 2170
NextBio 8763
PRO PR:P05413
Proteomes UP000005640
Bgee P05413
CleanEx HS_FABP3
ExpressionAtlas P05413
Genevestigator P05413
GO GO:0005829
GO:0005615
GO:0070062
GO:0016528
GO:0008092
GO:0050543
GO:0036041
GO:0005324
GO:0070538
GO:0042632
GO:0006631
GO:0044539
GO:0008285
GO:0055091
GO:0071073
GO:0046320
GO:0042493
GO:0070542
GO:0032868
Gene3D 2.40.128.20
InterPro IPR012674
IPR011038
IPR000463
IPR000566
Pfam PF00061
PRINTS PR00178
SUPFAM SSF50814
PROSITE PS00214

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005324

long-chain fatty acid transporter activity

PMID:10567233[1]

ECO:0000315

F

Table 2 shows that mutations in the amino acid sequence of FABH decreases binding affinity for long chain fatty acid oleic acid.

complete
CACAO 9953

involved_in

GO:0140214

positive regulation of long-chain fatty acid import into cell

PMID:10224224[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P11404

P

occurs_in:(UBERON:0000948)

Seeded From UniProt

complete

involved_in

GO:0015909

long-chain fatty acid transport

PMID:10224224[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P11404

P

occurs_in:(UBERON:0000948)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:23141496[3]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001969)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071073

positive regulation of phospholipid biosynthetic process

PMID:3421901[5]

ECO:0000305

curator inference used in manual assertion

GO:0036041

P

Seeded From UniProt

complete

enables

GO:0070538

oleic acid binding

PMID:3421901[5]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(CHEBI:30823)

Seeded From UniProt

complete

involved_in

GO:0055091

phospholipid homeostasis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P11404

P

occurs_in:(UBERON:0000955)

Seeded From UniProt

complete

involved_in

GO:0046320

regulation of fatty acid oxidation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P11404

P

occurs_in:(CL:0000746)

Seeded From UniProt

complete

involved_in

GO:0032365

intracellular lipid transport

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P11404

P

  • occurs_in:(UBERON:0000948)
  • transports_or_maintains_localization_of:(CHEBI:15904)

Seeded From UniProt

complete

involved_in

GO:0042632

cholesterol homeostasis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P11404

P

occurs_in:(UBERON:0000955)

Seeded From UniProt

complete

enables

GO:0036041

long-chain fatty acid binding

PMID:3421901[5]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(CHEBI:7896)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:16502470[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001914)

Seeded From UniProt

complete

enables

GO:0008092

cytoskeletal protein binding

PMID:17987659[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O76041

F

Seeded From UniProt

complete

involved_in

GO:0070542

response to fatty acid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07483
ensembl:ENSRNOP00000017325

P

Seeded From UniProt

complete

enables

GO:0050543

icosatetraenoic acid binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07483
ensembl:ENSRNOP00000017325

F

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07483
ensembl:ENSRNOP00000017325

P

Seeded From UniProt

complete

involved_in

GO:0032868

response to insulin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07483
ensembl:ENSRNOP00000017325

P

Seeded From UniProt

complete

part_of

GO:0016528

sarcoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07483
ensembl:ENSRNOP00000017325

C

Seeded From UniProt

complete

involved_in

GO:0015909

long-chain fatty acid transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07483
ensembl:ENSRNOP00000017325

P

Seeded From UniProt

complete

involved_in

GO:0006631

fatty acid metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07483
ensembl:ENSRNOP00000017325

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07483
ensembl:ENSRNOP00000017325

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07483
ensembl:ENSRNOP00000017325

C

Seeded From UniProt

complete

enables

GO:0005504

fatty acid binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07483
ensembl:ENSRNOP00000017325

F

Seeded From UniProt

complete

enables

GO:0005324

long-chain fatty acid transporter activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07483
ensembl:ENSRNOP00000017325

F

Seeded From UniProt

complete

involved_in

GO:2001245

regulation of phosphatidylcholine biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11404
ensembl:ENSMUSP00000070709

P

Seeded From UniProt

complete

involved_in

GO:0140214

positive regulation of long-chain fatty acid import into cell

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11404
ensembl:ENSMUSP00000070709

P

Seeded From UniProt

complete

involved_in

GO:0055091

phospholipid homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11404
ensembl:ENSMUSP00000070709

P

Seeded From UniProt

complete

involved_in

GO:0046320

regulation of fatty acid oxidation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11404
ensembl:ENSMUSP00000070709

P

Seeded From UniProt

complete

involved_in

GO:0042632

cholesterol homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11404
ensembl:ENSMUSP00000070709

P

Seeded From UniProt

complete

involved_in

GO:0032365

intracellular lipid transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11404
ensembl:ENSMUSP00000070709

P

Seeded From UniProt

complete

involved_in

GO:0015909

long-chain fatty acid transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11404
ensembl:ENSMUSP00000070709

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11404
ensembl:ENSMUSP00000070709

C

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000463
InterPro:IPR031259

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:23873799[9]
Reactome:R-HSA-5334794

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:7962070[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019433

triglyceride catabolic process

Reactome:R-HSA-163560

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0446

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Zimmerman, AW et al. (1999) Functional and conformational characterization of new mutants of heart fatty acid-binding protein. Biochem. J. 344 Pt 2 495-501 PubMed GONUTS page
  2. ↑ 2.0 2.1 Binas, B et al. (1999) Requirement for the heart-type fatty acid binding protein in cardiac fatty acid utilization. FASEB J. 13 805-12 PubMed GONUTS page
  3. ↑ Varrone, F et al. (2013) The circulating level of FABP3 is an indirect biomarker of microRNA-1. J. Am. Coll. Cardiol. 61 88-95 PubMed GONUTS page
  4. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Offner, GD et al. (1988) Characterization and amino acid sequence of a fatty acid-binding protein from human heart. Biochem. J. 252 191-8 PubMed GONUTS page
  6. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  7. ↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
  8. ↑ Holmes, WB & Moncman, CL (2008) Nebulette interacts with filamin C. Cell Motil. Cytoskeleton 65 130-42 PubMed GONUTS page
  9. ↑ Uitterdijk, A et al. (2013) Serial measurement of hFABP and high-sensitivity troponin I post-PCI in STEMI: how fast and accurate can myocardial infarct size and no-reflow be predicted? Am. J. Physiol. Heart Circ. Physiol. 305 H1104-10 PubMed GONUTS page
  10. ↑ Yang, Y et al. (1994) Members of the fatty acid binding protein family are differentiation factors for the mammary gland. J. Cell Biol. 127 1097-109 PubMed GONUTS page
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