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HUMAN:FA8

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) F8 (synonyms: F8C)
Protein Name(s) Coagulation factor VIII

Antihemophilic factor AHF Procoagulant component Factor VIIIa heavy chain, 200 kDa isoform Factor VIIIa heavy chain, 92 kDa isoform Factor VIII B chain Factor VIIIa light chain

External Links
UniProt P00451
EMBL M14113
X01179
M90707
K01740
M88648
M88628
M88629
M88630
M88631
M88632
M88633
M88634
M88635
M88636
M88638
M88639
M88640
M88641
M88642
M88643
M88644
M88645
M88646
M88647
AY769950
AK289947
AK313707
BX470111
AC109993
BX842559
BX842564
BX890586
BX842564
AC109993
BX470111
BX842559
BX890586
BX842559
AC109993
BX470111
BX842564
BX890586
BX890586
AC109993
BX470111
BX842559
BX842564
BX842559
AC109993
CH471172
BC022513
BC064380
BC098389
BC111967
BC111969
U80228
CCDS CCDS35457.1
CCDS44026.1
PIR I54318
RefSeq NP_000123.1
NP_063916.1
UniGene Hs.632836
Hs.654450
PDB 1CFG
1D7P
1FAC
1IQD
2R7E
3CDZ
3HNB
3HNY
3HOB
3J2Q
3J2S
4BDV
4KI5
PDBsum 1CFG
1D7P
1FAC
1IQD
2R7E
3CDZ
3HNB
3HNY
3HOB
3J2Q
3J2S
4BDV
4KI5
ProteinModelPortal P00451
SMR P00451
BioGrid 108455
DIP DIP-29774N
IntAct P00451
MINT MINT-202317
STRING 9606.ENSP00000353393
BindingDB P00451
ChEMBL CHEMBL3143
DrugBank DB00100
DB00055
GuidetoPHARMACOLOGY 2607
Allergome 9868
PhosphoSite P00451
UniCarbKB P00451
DMDM 119767
PaxDb P00451
PRIDE P00451
DNASU 2157
Ensembl ENST00000330287
ENST00000360256
GeneID 2157
KEGG hsa:2157
UCSC uc004fms.3
uc004fmt.3
CTD 2157
GeneCards GC0XM154064
GeneReviews F8
HGNC HGNC:3546
HPA CAB018777
MIM 134500
300841
306700
neXtProt NX_P00451
Orphanet 169808
169805
169802
177926
PharmGKB PA27952
eggNOG NOG151351
GeneTree ENSGT00760000119073
HOGENOM HOG000231686
HOVERGEN HBG106657
InParanoid P00451
KO K03899
OMA WHVIGMG
PhylomeDB P00451
TreeFam TF329807
Reactome REACT_326
EvolutionaryTrace P00451
GeneWiki Factor_VIII
GenomeRNAi 2157
NextBio 8713
PRO PR:P00451
Proteomes UP000005640
Bgee P00451
CleanEx HS_F8
ExpressionAtlas P00451
Genevestigator P00451
GO GO:0005576
GO:0005615
GO:0005886
GO:0031093
GO:0005507
GO:0016491
GO:0004252
GO:0006953
GO:0007596
GO:0007597
GO:0007155
GO:0030168
GO:0002576
Gene3D 2.60.120.260
2.60.40.420
InterPro IPR000421
IPR001117
IPR011706
IPR011707
IPR002355
IPR008972
IPR024715
IPR014707
IPR008979
PANTHER PTHR10127:SF50
Pfam PF00394
PF07731
PF07732
PF00754
PIRSF PIRSF000354
SMART SM00231
SUPFAM SSF49503
SSF49785
PROSITE PS01285
PS01286
PS50022
PS00079

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005576

extracellular region

PMID:14718574[1]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007597

blood coagulation, intrinsic pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000741237
RGD:727845

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000741237
RGD:727845

C

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048208

C

Seeded From UniProt

complete

involved_in

GO:0007597

blood coagulation, intrinsic pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZEB1
ensembl:ENSRNOP00000050792

P

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZEB1
ensembl:ENSRNOP00000050792

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZEB1
ensembl:ENSRNOP00000050792

C

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011706
InterPro:IPR011707

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011706

F

Seeded From UniProt

complete

involved_in

GO:0030168

platelet activation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014707

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001117
InterPro:IPR011706

P

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

PMID:8275087[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048208

COPII vesicle coating

Reactome:R-HSA-204005

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0033116

endoplasmic reticulum-Golgi intermediate compartment membrane

Reactome:R-HSA-5694446

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031093

platelet alpha granule lumen

Reactome:R-HSA-481007

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030134

COPII-coated ER to Golgi transport vesicle

Reactome:R-HSA-5694446
Reactome:R-HSA-5694441
Reactome:R-HSA-5694439
Reactome:R-HSA-5694418
Reactome:R-HSA-5694409
Reactome:R-HSA-203973

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

involved_in

GO:0007597

blood coagulation, intrinsic pathway

Reactome:R-HSA-140837

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006888

endoplasmic reticulum to Golgi vesicle-mediated transport

Reactome:R-HSA-199977

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-5607043
Reactome:R-HSA-158278
Reactome:R-HSA-158164

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

Reactome:R-HSA-5694527
Reactome:R-HSA-5694522
Reactome:R-HSA-5694431
Reactome:R-HSA-5694417
Reactome:R-HSA-204008
Reactome:R-HSA-203973

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-5607043
Reactome:R-HSA-5607002
Reactome:R-HSA-481007
Reactome:R-HSA-158137
Reactome:R-HSA-158118

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

involved_in

GO:0002576

platelet degranulation

Reactome:R-HSA-114608

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006953

acute-phase response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0011

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0094

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0007599

hemostasis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0356

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0112

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
  2. ↑ 2.0 2.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ Lakich, D et al. (1993) Inversions disrupting the factor VIII gene are a common cause of severe haemophilia A. Nat. Genet. 5 236-41 PubMed GONUTS page
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