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HUMAN:ETFD

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ETFDH
Protein Name(s) Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

ETF-QO ETF-ubiquinone oxidoreductase Electron-transferring-flavoprotein dehydrogenase ETF dehydrogenase

External Links
UniProt Q16134
EMBL S69232
AK304838
BX538129
AC107219
BC011890
CCDS CCDS3800.1
CCDS64090.1
PIR S41115
RefSeq NP_001268666.1
NP_004444.2
UniGene Hs.155729
ProteinModelPortal Q16134
SMR Q16134
BioGrid 108411
IntAct Q16134
STRING 9606.ENSP00000303552
PhosphoSite Q16134
DMDM 292495008
MaxQB Q16134
PaxDb Q16134
PRIDE Q16134
Ensembl ENST00000307738
ENST00000511912
GeneID 2110
KEGG hsa:2110
UCSC uc003iqb.3
CTD 2110
GeneCards GC04P159593
H-InvDB HIX0200647
HGNC HGNC:3483
HPA HPA041978
MIM 231675
231680
neXtProt NX_Q16134
Orphanet 394532
394529
PharmGKB PA27899
eggNOG COG0644
GeneTree ENSGT00390000010773
HOGENOM HOG000259450
HOVERGEN HBG005615
InParanoid Q16134
KO K00311
OMA EKDIRVC
OrthoDB EOG7WX07W
PhylomeDB Q16134
TreeFam TF105687
BioCyc MetaCyc:HS10326-MONOMER
BRENDA 1.5.5.1
Reactome REACT_22393
ChiTaRS ETFDH
GeneWiki ETFDH
GenomeRNAi 2110
NextBio 35477610
PRO PR:Q16134
Proteomes UP000005640
Bgee Q16134
CleanEx HS_ETFDH
ExpressionAtlas Q16134
Genevestigator Q16134
GO GO:0031305
GO:0005759
GO:0031966
GO:0051539
GO:0009055
GO:0004174
GO:0050660
GO:0046872
GO:0016491
GO:0043783
GO:0048038
GO:0048039
GO:0044237
GO:0022900
GO:0033539
GO:0022904
GO:0006979
GO:0044281
InterPro IPR017896
IPR007859
IPR000103
Pfam PF05187
PRINTS PR00469
PROSITE PS51379

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004174

electron-transferring-flavoprotein dehydrogenase activity

PMID:12049629[1], PMID:14640977[2], PMID:8306995[3]

ECO:0000314

F

Seeded from UniProt.

complete

GO:0009055

electron carrier activity

PMID:8306995[3], PMID:12049629[1]

ECO:0000314

F

Seeded from UniProt.

complete

GO:0016491

oxidoreductase activity

PMID:14640977[2]

ECO:0000314

F

Seeded from UniProt.

complete

GO:0048038

quinone binding

PMID:14640977[2]

ECO:0000314

F

Seeded from UniProt.

complete

GO:0048039

ubiquinone binding

PMID:14640977[2]

ECO:0000314

F

Seeded from UniProt.

complete

GO:0051539

4 iron, 4 sulfur cluster binding

PMID:18037314[4]

ECO:0000314

F

Seeded from UniProt.

complete

GO:0031305

integral to mitochondrial inner membrane

PMID:8306995[3]

ECO:0000314

C

Seeded from UniProt.

complete

GO:0031966

mitochondrial membrane

PMID:12049629[1]

ECO:0000314

C

Seeded from UniProt.

complete

GO:0022900

electron transport chain

PMID:8306995[3], PMID:12049629[1]

ECO:0000314

P

Seeded from UniProt.

complete

involved_in

GO:0033539

fatty acid beta-oxidation using acyl-CoA dehydrogenase

PMID:17412732[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

PMID:18037314[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

PMID:17050691[6]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55931

F

Seeded From UniProt

complete

enables

GO:0048039

ubiquinone binding

PMID:14640977[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0048038

quinone binding

PMID:14640977[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043783

oxidoreductase activity, oxidizing metal ions with flavin as acceptor

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55931

F

Seeded From UniProt

complete

part_of

GO:0031966

mitochondrial membrane

PMID:12049629[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031305

integral component of mitochondrial inner membrane

PMID:8306995[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0022900

electron transport chain

PMID:8306995[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0022900

electron transport chain

PMID:12049629[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

PMID:14640977[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0009055

electron transfer activity

PMID:8306995[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0009055

electron transfer activity

PMID:12049629[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q921G7

P

Seeded From UniProt

complete

enables

GO:0004174

electron-transferring-flavoprotein dehydrogenase activity

PMID:8306995[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004174

electron-transferring-flavoprotein dehydrogenase activity

PMID:14640977[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004174

electron-transferring-flavoprotein dehydrogenase activity

PMID:12049629[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000835262
UniProtKB:P55931
UniProtKB:Q16134

F

Seeded From UniProt

complete

enables

GO:0048039

ubiquinone binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000835262
UniProtKB:P55931
UniProtKB:Q16134

F

Seeded From UniProt

complete

enables

GO:0043783

oxidoreductase activity, oxidizing metal ions with flavin as acceptor

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000835262
UniProtKB:P55931

F

Seeded From UniProt

complete

part_of

GO:0031305

integral component of mitochondrial inner membrane

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000065332
UniProtKB:Q16134

C

Seeded From UniProt

complete

involved_in

GO:0022904

respiratory electron transport chain

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000835262
ZFIN:ZDB-GENE-040912-168

P

Seeded From UniProt

complete

enables

GO:0009055

electron transfer activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000835262
RGD:735052
UniProtKB:P55931
UniProtKB:Q16134

F

Seeded From UniProt

complete

enables

GO:0004174

electron-transferring-flavoprotein dehydrogenase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0033465
PANTHER:PTN000835262
UniProtKB:P55931
UniProtKB:Q16134

F

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q921G7
ensembl:ENSMUSP00000029386

P

Seeded From UniProt

complete

enables

GO:0004174

electron-transferring-flavoprotein dehydrogenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040156

F

Seeded From UniProt

complete

involved_in

GO:0022900

electron transport chain

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040156

P

Seeded From UniProt

complete

enables

GO:0004174

electron-transferring-flavoprotein dehydrogenase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.5.5.1

F

Seeded From UniProt

complete

involved_in

GO:0022904

respiratory electron transport chain

Reactome:R-HSA-611105

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

Reactome:R-HSA-169270

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004174

electron-transferring-flavoprotein dehydrogenase activity

Reactome:R-HSA-169270

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0051536

iron-sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0411

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0249
UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0004

F

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0999
UniProtKB-SubCell:SL-0168

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Simkovic, M et al. (2002) Expression of human electron transfer flavoprotein-ubiquinone oxidoreductase from a baculovirus vector: kinetic and spectral characterization of the human protein. Biochem. J. 364 659-67 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Simkovic, M & Frerman, FE (2004) Alternative quinone substrates and inhibitors of human electron-transfer flavoprotein-ubiquinone oxidoreductase. Biochem. J. 378 633-40 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Goodman, SI et al. (1994) Molecular cloning and expression of a cDNA encoding human electron transfer flavoprotein-ubiquinone oxidoreductase. Eur. J. Biochem. 219 277-86 PubMed GONUTS page
  4. ↑ 4.0 4.1 Fielding, AJ et al. (2008) Electron spin relaxation enhancement measurements of interspin distances in human, porcine, and Rhodobacter electron transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO). J. Magn. Reson. 190 222-32 PubMed GONUTS page
  5. ↑ Gempel, K et al. (2007) The myopathic form of coenzyme Q10 deficiency is caused by mutations in the electron-transferring-flavoprotein dehydrogenase (ETFDH) gene. Brain 130 2037-44 PubMed GONUTS page
  6. ↑ Zhang, J et al. (2006) Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool. Proc. Natl. Acad. Sci. U.S.A. 103 16212-7 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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