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HUMAN:EST2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CES2 (synonyms: ICE) | |
| Protein Name(s) | Cocaine esterase
Carboxylesterase 2 CE-2 hCE-2 Methylumbelliferyl-acetate deacetylase 2 | |
| External Links | ||
| UniProt | O00748 | |
| EMBL | Y09616 D50579 U60553 AL713761 AK290482 BX538086 AY851164 AC009084 BC032095 | |
| PIR | JC5408 | |
| RefSeq | NP_003860.2 NP_932327.1 | |
| UniGene | Hs.282975 | |
| ProteinModelPortal | O00748 | |
| SMR | O00748 | |
| IntAct | O00748 | |
| STRING | 9606.ENSP00000317842 | |
| BindingDB | O00748 | |
| ChEMBL | CHEMBL3180 | |
| DrugBank | DB06695 DB00762 DB00688 DB06209 | |
| MEROPS | S09.984 | |
| PhosphoSite | O00748 | |
| MaxQB | O00748 | |
| PaxDb | O00748 | |
| PRIDE | O00748 | |
| DNASU | 8824 | |
| Ensembl | ENST00000417689 | |
| GeneID | 8824 | |
| KEGG | hsa:8824 | |
| UCSC | uc002eqs.3 | |
| CTD | 8824 | |
| GeneCards | GC16P066969 | |
| HGNC | HGNC:1864 | |
| HPA | HPA018897 | |
| MIM | 605278 | |
| neXtProt | NX_O00748 | |
| PharmGKB | PA377 | |
| eggNOG | COG2272 | |
| GeneTree | ENSGT00760000118946 | |
| HOVERGEN | HBG008839 | |
| InParanoid | O00748 | |
| KO | K03927 | |
| OrthoDB | EOG7RBZ7R | |
| PhylomeDB | O00748 | |
| TreeFam | TF315470 | |
| BRENDA | 3.1.1.1 | |
| SABIO-RK | O00748 | |
| ChiTaRS | CES2 | |
| GeneWiki | Carboxylesterase_2 | |
| GenomeRNAi | 8824 | |
| NextBio | 33104 | |
| PRO | PR:O00748 | |
| Proteomes | UP000005640 | |
| Bgee | O00748 | |
| CleanEx | HS_CES2 | |
| ExpressionAtlas | O00748 | |
| Genevestigator | O00748 | |
| GO | GO:0005783 GO:0005788 GO:0052689 GO:0047374 GO:0009056 | |
| Gene3D | 3.40.50.1820 | |
| InterPro | IPR029058 IPR002018 IPR019826 IPR019819 | |
| Pfam | PF00135 | |
| SUPFAM | SSF53474 | |
| PROSITE | PS00122 PS00941 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004091 |
carboxylesterase activity |
ECO:0000315 |
F |
This paper describes how the importance of Cocaine esterase and how it can have a positive effect on individuals with an addiction to Cocaine. From this, Figures 1-4 provide necessary information about the annotation. |
complete | |||||
|
enables |
GO:0052689 |
carboxylic ester hydrolase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
part_of:(GO:0006693) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006693 |
prostaglandin metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052689 |
carboxylic ester hydrolase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000592 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95420 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0047374 |
methylumbelliferyl-acetate deacetylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052689 |
carboxylic ester hydrolase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0080030 |
methyl indole-3-acetate esterase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052689 |
carboxylic ester hydrolase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009056 |
catabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006805 |
xenobiotic metabolic process |
Reactome:R-HSA-211945 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
Reactome:R-HSA-5693691 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052689 |
carboxylic ester hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Narasimhan, D et al. (2012) Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addiction. Future Med Chem 4 137-50 PubMed GONUTS page
- ↑ 2.0 2.1 Xie, S et al. (2010) Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2. Chem. Res. Toxicol. 23 1890-904 PubMed GONUTS page
- ↑ 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 Pindel, EV et al. (1997) Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin. J. Biol. Chem. 272 14769-75 PubMed GONUTS page
- ↑ Schwer, H et al. (1997) Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver. Biochem. Biophys. Res. Commun. 233 117-20 PubMed GONUTS page
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