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HUMAN:EDN3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | EDN3 | |
| Protein Name(s) | Endothelin-3
ET-3 Preproendothelin-3 PPET3 | |
| External Links | ||
| UniProt | P14138 | |
| EMBL | J05081 X52001 BT007085 AY444503 AL035250 AL035250 AL035250 CH471077 CH471077 CH471077 BC008876 BC053866 | |
| CCDS | CCDS13477.1 CCDS13478.1 CCDS13479.1 | |
| PIR | A34378 | |
| RefSeq | NP_001289384.1 NP_001289385.1 NP_996915.1 NP_996916.1 NP_996917.1 | |
| UniGene | Hs.1408 | |
| ProteinModelPortal | P14138 | |
| BioGrid | 108230 | |
| STRING | 9606.ENSP00000337128 | |
| DMDM | 119618 | |
| PaxDb | P14138 | |
| PRIDE | P14138 | |
| DNASU | 1908 | |
| Ensembl | ENST00000311585 ENST00000337938 ENST00000371028 ENST00000395654 | |
| GeneID | 1908 | |
| KEGG | hsa:1908 | |
| UCSC | uc002yap.3 uc002yar.3 uc002yas.3 | |
| CTD | 1908 | |
| GeneCards | GC20P057875 | |
| GeneReviews | EDN3 | |
| HGNC | HGNC:3178 | |
| HPA | HPA057987 | |
| MIM | 131242 209880 613265 613712 | |
| neXtProt | NX_P14138 | |
| Orphanet | 388 661 897 | |
| PharmGKB | PA27616 | |
| eggNOG | NOG41573 | |
| GeneTree | ENSGT00530000063310 | |
| HOGENOM | HOG000231110 | |
| HOVERGEN | HBG051442 | |
| InParanoid | P14138 | |
| KO | K05227 | |
| OMA | HHRSRRC | |
| OrthoDB | EOG7PCJHP | |
| PhylomeDB | P14138 | |
| TreeFam | TF333184 | |
| Reactome | REACT_14819 REACT_18283 | |
| GeneWiki | Endothelin_3 | |
| GenomeRNAi | 1908 | |
| NextBio | 7765 | |
| PMAP-CutDB | P14138 | |
| PRO | PR:P14138 | |
| Proteomes | UP000005640 | |
| Bgee | P14138 | |
| CleanEx | HS_EDN3 | |
| ExpressionAtlas | P14138 | |
| Genevestigator | P14138 | |
| GO | GO:0005576 GO:0005615 GO:0005179 GO:0005102 GO:0008015 GO:0007166 GO:0007267 GO:0048016 GO:0030318 GO:0007275 GO:0001755 GO:0030182 GO:0030593 GO:0030072 GO:0008284 GO:0010460 GO:0046887 GO:0002690 GO:0043406 GO:0045840 GO:0048070 GO:0003100 GO:0019229 GO:0007165 GO:0042310 GO:0014826 | |
| InterPro | IPR020475 IPR019764 IPR001928 | |
| Pfam | PF00322 | |
| PRINTS | PR00365 | |
| SMART | SM00272 | |
| PROSITE | PS00270 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0031708 |
endothelin B receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048016 |
inositol phosphate-mediated signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046887 |
positive regulation of hormone secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045840 |
positive regulation of mitotic nuclear division |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043406 |
positive regulation of MAP kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042310 |
vasoconstriction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042310 |
vasoconstriction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030593 |
neutrophil chemotaxis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030072 |
peptide hormone secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0014826 |
vein smooth muscle contraction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
NOT|involved_in |
GO:0014824 |
artery smooth muscle contraction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010460 |
positive regulation of heart rate |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007166 |
cell surface receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005179 |
hormone activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005179 |
hormone activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0003100 |
regulation of systemic arterial blood pressure by endothelin |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002690 |
positive regulation of leukocyte chemotaxis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045597 |
positive regulation of cell differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010468 |
regulation of gene expression |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005623 |
cell |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0010961 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901381 |
positive regulation of potassium ion transmembrane transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48299 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048070 |
regulation of developmental pigmentation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48299 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030334 |
regulation of cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48299 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030318 |
melanocyte differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48299 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48299 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010961 |
cellular magnesium ion homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48299 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48299 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006874 |
cellular calcium ion homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48299 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001755 |
neural crest cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48299 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019229 |
regulation of vasoconstriction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008015 |
blood circulation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007267 |
cell-cell signaling |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
Reactome:R-HSA-388396 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-749452 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042310 |
vasoconstriction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050880 |
regulation of blood vessel size |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Sakamoto, A et al. (1991) Cloning and functional expression of human cDNA for the ETB endothelin receptor. Biochem. Biophys. Res. Commun. 178 656-63 PubMed GONUTS page
- ↑ Yada, Y et al. (1991) Effects of endothelins on signal transduction and proliferation in human melanocytes. J. Biol. Chem. 266 18352-7 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Maggi, M et al. (2000) Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons. J. Clin. Endocrinol. Metab. 85 1658-65 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Inoue, A et al. (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. U.S.A. 86 2863-7 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Bogoni, G et al. (1996) Characterization of endothelin receptors in the human umbilical artery and vein. Br. J. Pharmacol. 119 1600-4 PubMed GONUTS page
- ↑ 6.0 6.1 Elferink, JG & De Koster, BM (1998) The involvement of protein kinase G in stimulation of neutrophil migration by endothelins. Eur. J. Pharmacol. 350 285-91 PubMed GONUTS page
- ↑ Dimoulios, P et al. (2005) Ursodeoxycholic acid reduces increased circulating endothelin 2 in primary biliary cirrhosis. Aliment. Pharmacol. Ther. 21 227-34 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Evangelisti, C et al. (2012) Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways. Neurogastroenterol. Motil. 24 e497-508 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Calderone, RA (1993) Molecular interactions at the interface of Candida albicans and host cells. Arch. Med. Res. 24 275-9 PubMed GONUTS page
- ↑ Edery, P et al. (1996) Mutation of the endothelin-3 gene in the Waardenburg-Hirschsprung disease (Shah-Waardenburg syndrome). Nat. Genet. 12 442-4 PubMed GONUTS page
c
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i
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p
- GO:0030072 ! peptide hormone secretion
- GO:0002690 ! positive regulation of leukocyte chemotaxis
- GO:1901381 ! positive regulation of potassium ion transmembrane transport
- GO:0046887 ! positive regulation of hormone secretion
- GO:0045840 ! positive regulation of mitotic nuclear division
- GO:0043406 ! positive regulation of MAP kinase activity
- GO:0010460 ! positive regulation of heart rate
- GO:0045597 ! positive regulation of cell differentiation
- GO:0008284 ! positive regulation of cell population proliferation
- Primates
r
- GO:0003100 ! regulation of systemic arterial blood pressure by endothelin
- GO:0030334 ! regulation of cell migration
- GO:0048070 ! regulation of developmental pigmentation
- GO:0010468 ! regulation of gene expression
- GO:0050880 ! regulation of blood vessel size
- GO:0010469 ! regulation of signaling receptor activity
- GO:0019229 ! regulation of vasoconstriction
