HUMAN:EDN1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	EDN1
Protein Name(s)	Endothelin-1 Preproendothelin-1 PPET1 Endothelin-1 ET-1 Big endothelin-1
External Links
UniProt	P05305
EMBL	Y00749 M25380 M25377 M25378 M25379 J05008 S56805 AY434104 Z98050 BC009720 M25549
CCDS	CCDS4522.1
PIR	A36517
RefSeq	NP_001161791.1 NP_001946.3
UniGene	Hs.511899 Hs.713645
PDB	1EDN 1EDP 1T7H 1V6R
PDBsum	1EDN 1EDP 1T7H 1V6R
ProteinModelPortal	P05305
BioGrid	108228
IntAct	P05305
MINT	MINT-1387120
STRING	9606.ENSP00000368683
PhosphoSite	P05305
DMDM	119610
PaxDb	P05305
PRIDE	P05305
DNASU	1906
Ensembl	ENST00000379375
GeneID	1906
KEGG	hsa:1906
UCSC	uc003nad.3
CTD	1906
GeneCards	GC06P012290
H-InvDB	HIX0033211
HGNC	HGNC:3176
HPA	CAB032500 CAB037291 HPA031976
MIM	131240 612798 615706
neXtProt	NX_P05305
Orphanet	137888
PharmGKB	PA27614
eggNOG	NOG46593
HOGENOM	HOG000231110
HOVERGEN	HBG051441
InParanoid	P05305
KO	K16366
OMA	RCQCASQ
OrthoDB	EOG7PS1H7
PhylomeDB	P05305
TreeFam	TF333184
Reactome	REACT_14819 REACT_18283
EvolutionaryTrace	P05305
GeneWiki	Endothelin_1
GenomeRNAi	1906
NextBio	7757
PMAP-CutDB	P05305
PRO	PR:P05305
Proteomes	UP000005640
Bgee	P05305
CleanEx	HS_EDN1
ExpressionAtlas	P05305
Genevestigator	P05305
GO	GO:0045178 GO:0005737 GO:0005576 GO:0005615 GO:0048237 GO:0033093 GO:0005125 GO:0031707 GO:0031708 GO:0005179 GO:0014824 GO:0007589 GO:0019722 GO:0051216 GO:0016049 GO:0007166 GO:0007267 GO:0071277 GO:0035690 GO:0071398 GO:0071385 GO:0071456 GO:0071346 GO:0071347 GO:0071389 GO:0071375 GO:0071560 GO:0071356 GO:0009953 GO:0042045 GO:0007186 GO:0015758 GO:0007507 GO:0001821 GO:0001701 GO:0048016 GO:0045321 GO:0060137 GO:0051899 GO:0042474 GO:0010259 GO:0030195 GO:0030818 GO:0032269 GO:0046888 GO:0051771 GO:0034392 GO:0000122 GO:0014032 GO:0030185 GO:0001569 GO:0030072 GO:0014065 GO:0031583 GO:0010613 GO:0030335 GO:0008284 GO:0045793 GO:0070101 GO:0007204 GO:0051482 GO:0010595 GO:0010460 GO:0046887 GO:0043507 GO:0043406 GO:0045840 GO:0090023 GO:0045429 GO:0042482 GO:0032308 GO:0060585 GO:0010870 GO:0035815 GO:0060298 GO:0048661 GO:0045987 GO:0045944 GO:0035810 GO:0001516 GO:0042313 GO:0007205 GO:0006885 GO:0051930 GO:0003100 GO:0019229 GO:0007585 GO:0014823 GO:0043200 GO:0071548 GO:0044321 GO:0032496 GO:0035994 GO:0035094 GO:0010193 GO:0034696 GO:1902074 GO:0033574 GO:0043179 GO:0019233 GO:0042554 GO:0042310 GO:0014826
InterPro	IPR020475 IPR019764 IPR001928
Pfam	PF00322
PRINTS	PR00365
SMART	SM00272
PROSITE	PS00270

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24117217^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000746) occurs_in:(UBERON:0007221) regulates_transcription_of:(ENSEMBL:ENSG00000120937)\|occurs_in(CL:0000746) occurs_in:(UBERON:0007221) regulates_transcription_of:(ENSEMBL:ENSG00000175206)	Seeded From UniProt	complete
involved_in	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	PMID:24117217^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0007221)	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:24117217^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(PR:000003112)	Seeded From UniProt	complete
involved_in	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	PMID:24117217^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS000006FDD4_9606,RNAcentral:URS000013D17D_9606	P	occurs_in:(UBERON:0007221)	Seeded From UniProt	complete
enables	GO:0031708	endothelin B receptor binding	PMID:1713452^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P24530	F		Seeded From UniProt	complete
involved_in	GO:0070101	positive regulation of chemokine-mediated signaling pathway	PMID:17178876^[3]	ECO:0000305	curator inference used in manual assertion	GO:0010870	P		Seeded From UniProt	complete
involved_in	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	PMID:9492062^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060298	positive regulation of sarcomere organization	PMID:12847114^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process	PMID:16820593^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:10393673^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	PMID:1917960^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046887	positive regulation of hormone secretion	PMID:10770212^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	PMID:10770212^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045793	positive regulation of cell size	PMID:12847114^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	PMID:12847114^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:12847114^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:10770212^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042313	protein kinase C deactivation	PMID:16820593^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	PMID:2649896^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	PMID:11410113^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032269	negative regulation of cellular protein metabolic process	PMID:19767294^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031708	endothelin B receptor binding	PMID:10770212^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031707	endothelin A receptor binding	PMID:10770212^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
NOT\|involved_in	GO:0030593	neutrophil chemotaxis	PMID:9696419^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:9696419^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030185	nitric oxide transport	PMID:16820593^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030072	peptide hormone secretion	PMID:10770212^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	PMID:1917960^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	PMID:10770212^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014826	vein smooth muscle contraction	PMID:9422810^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014824	artery smooth muscle contraction	PMID:8982507^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:17078114^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010870	positive regulation of receptor biosynthetic process	PMID:17178876^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010613	positive regulation of cardiac muscle hypertrophy	PMID:12847114^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010460	positive regulation of heart rate	PMID:2649896^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:1917960^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:17078114^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:12379507^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:1917960^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:17078114^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:1713452^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12379507^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15691296^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10770212^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16820593^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:2649896^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:10770212^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:19767294^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003100	regulation of systemic arterial blood pressure by endothelin	PMID:2649896^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001516	prostaglandin biosynthetic process	PMID:9492062^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19767294^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:1902074	response to salt	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0090023	positive regulation of neutrophil chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0071559	response to transforming growth factor beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0071548	response to dexamethasone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0071398	cellular response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0071389	cellular response to mineralocorticoid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0071385	cellular response to glucocorticoid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0071375	cellular response to peptide hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0071346	cellular response to interferon-gamma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0060137	maternal process involved in parturition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0051930	regulation of sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0051899	membrane depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
part_of	GO:0048237	rough endoplasmic reticulum lumen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	C		Seeded From UniProt	complete
involved_in	GO:0046888	negative regulation of hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0045987	positive regulation of smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
part_of	GO:0045178	basal part of cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	C		Seeded From UniProt	complete
involved_in	GO:0044321	response to leptin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0042554	superoxide anion generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0042482	positive regulation of odontogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0042045	epithelial fluid transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0035994	response to muscle stretch	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0034696	response to prostaglandin F	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0034392	negative regulation of smooth muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
part_of	GO:0033093	Weibel-Palade body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	C		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0032308	positive regulation of prostaglandin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
enables	GO:0031708	endothelin B receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	F		Seeded From UniProt	complete
enables	GO:0031707	endothelin A receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	F		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0014824	artery smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0010259	multicellular organism aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0010193	response to ozone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	C		Seeded From UniProt	complete
involved_in	GO:0001821	histamine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22388 ensembl:ENSRNOP00000019361	P		Seeded From UniProt	complete
involved_in	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0045987	positive regulation of smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0043179	rhythmic excitation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0042474	middle ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0035815	positive regulation of renal sodium excretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0035810	positive regulation of urine volume	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
enables	GO:0031707	endothelin A receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	F		Seeded From UniProt	complete
involved_in	GO:0031583	phospholipase D-activating G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0014032	neural crest cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0010827	regulation of glucose transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0007589	body fluid secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0007585	respiratory gaseous exchange	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0006885	regulation of pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	F		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22387 ensembl:ENSMUSP00000021796	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001928 InterPro:IPR019764	C		Seeded From UniProt	complete
involved_in	GO:0019229	regulation of vasoconstriction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001928 InterPro:IPR019764	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:8999856^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045321	leukocyte activation	PMID:16820593^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030195	negative regulation of blood coagulation	PMID:16820593^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014824	artery smooth muscle contraction	PMID:1725334^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:8999856^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030133	transport vesicle	Reactome:R-HSA-8877620	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-8876868 Reactome:R-HSA-749452 Reactome:R-HSA-749448 Reactome:R-HSA-388560 Reactome:R-HSA-379048	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0839	P		Seeded From UniProt	complete
involved_in	GO:0050880	regulation of blood vessel size	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0838	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Song, DW et al. (2014) The miR-19a/b family positively regulates cardiomyocyte hypertrophy by targeting atrogin-1 and MuRF-1. Biochem. J. 457 151-62 PubMed GONUTS page
↑ ^2.0 ^2.1 Sakamoto, A et al. (1991) Cloning and functional expression of human cDNA for the ETB endothelin receptor. Biochem. Biophys. Res. Commun. 178 656-63 PubMed GONUTS page
↑ ^3.0 ^3.1 Wilson, JL et al. (2006) Endothelins induce CCR7 expression by breast tumor cells via endothelin receptor A and hypoxia-inducible factor-1. Cancer Res. 66 11802-7 PubMed GONUTS page
↑ ^4.0 ^4.1 Leis, HJ et al. (1998) Prostaglandin endoperoxide synthase-2 contributes to the endothelin/sarafotoxin-induced prostaglandin E2 synthesis in mouse osteoblastic cells (MC3T3-E1): evidence for a protein tyrosine kinase-signaling pathway and involvement of protein kinase C. Endocrinology 139 1268-77 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Koga, A et al. (2003) Adenovirus-mediated overexpression of caveolin-3 inhibits rat cardiomyocyte hypertrophy. Hypertension 42 213-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Ramzy, D et al. (2006) Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway. Circulation 114 I319-26 PubMed GONUTS page
↑ Yang, Z et al. (1999) Endothelin-1 potentiates human smooth muscle cell growth to PDGF: effects of ETA and ETB receptor blockade. Circulation 100 5-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Yada, Y et al. (1991) Effects of endothelins on signal transduction and proliferation in human melanocytes. J. Biol. Chem. 266 18352-7 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 Maggi, M et al. (2000) Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons. J. Clin. Endocrinol. Metab. 85 1658-65 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Inoue, A et al. (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. U.S.A. 86 2863-7 PubMed GONUTS page
↑ Hillier, C et al. (2001) Effect of adrenomedullin on the production of endothelin-1 and on its vasoconstrictor action in resistance arteries: evidence for a receptor-specific functional interaction in patients with heart failure. Clin. Sci. 101 45-51 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Helbing, T et al. (2010) Krüppel-like factor 15 regulates BMPER in endothelial cells. Cardiovasc. Res. 85 551-9 PubMed GONUTS page
↑ ^13.0 ^13.1 Elferink, JG & De Koster, BM (1998) The involvement of protein kinase G in stimulation of neutrophil migration by endothelins. Eur. J. Pharmacol. 350 285-91 PubMed GONUTS page
↑ Maguire, JJ et al. (1997) Endothelin converting enzyme (ECE) activity in human vascular smooth muscle. Br. J. Pharmacol. 122 1647-54 PubMed GONUTS page
↑ Bogoni, G et al. (1996) Characterization of endothelin receptors in the human umbilical artery and vein. Br. J. Pharmacol. 119 1600-4 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Grant, K et al. (2007) Mechanisms of endothelin 1-stimulated proliferation in colorectal cancer cell lines. Br J Surg 94 106-12 PubMed GONUTS page
↑ ^17.0 ^17.1 Evans, JJ et al. (2002) Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells. J. Endocrinol. 175 225-32 PubMed GONUTS page
↑ Dimoulios, P et al. (2005) Ursodeoxycholic acid reduces increased circulating endothelin 2 in primary biliary cirrhosis. Aliment. Pharmacol. Ther. 21 227-34 PubMed GONUTS page
↑ ^19.0 ^19.1 Noiri, E et al. (1997) Permissive role of nitric oxide in endothelin-induced migration of endothelial cells. J. Biol. Chem. 272 1747-52 PubMed GONUTS page
↑ McKay, KO et al. (1991) Functional and autoradiographic studies of endothelin-1 and endothelin-2 in human bronchi, pulmonary arteries, and airway parasympathetic ganglia. J. Cardiovasc. Pharmacol. 17 Suppl 7 S206-9 PubMed GONUTS page

[PMID:24117217-1] 1.0 ^1.1 ^1.2 ^1.3 Song, DW et al. (2014) The miR-19a/b family positively regulates cardiomyocyte hypertrophy by targeting atrogin-1 and MuRF-1. Biochem. J. 457 151-62 PubMed GONUTS page

[PMID:1713452-2] 2.0 ^2.1 Sakamoto, A et al. (1991) Cloning and functional expression of human cDNA for the ETB endothelin receptor. Biochem. Biophys. Res. Commun. 178 656-63 PubMed GONUTS page

[PMID:17178876-3] 3.0 ^3.1 Wilson, JL et al. (2006) Endothelins induce CCR7 expression by breast tumor cells via endothelin receptor A and hypoxia-inducible factor-1. Cancer Res. 66 11802-7 PubMed GONUTS page

[PMID:9492062-4] 4.0 ^4.1 Leis, HJ et al. (1998) Prostaglandin endoperoxide synthase-2 contributes to the endothelin/sarafotoxin-induced prostaglandin E2 synthesis in mouse osteoblastic cells (MC3T3-E1): evidence for a protein tyrosine kinase-signaling pathway and involvement of protein kinase C. Endocrinology 139 1268-77 PubMed GONUTS page

[PMID:12847114-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Koga, A et al. (2003) Adenovirus-mediated overexpression of caveolin-3 inhibits rat cardiomyocyte hypertrophy. Hypertension 42 213-9 PubMed GONUTS page

[PMID:16820593-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Ramzy, D et al. (2006) Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway. Circulation 114 I319-26 PubMed GONUTS page

[PMID:10393673-7] Yang, Z et al. (1999) Endothelin-1 potentiates human smooth muscle cell growth to PDGF: effects of ETA and ETB receptor blockade. Circulation 100 5-8 PubMed GONUTS page

[PMID:1917960-8] 8.0 ^8.1 ^8.2 ^8.3 Yada, Y et al. (1991) Effects of endothelins on signal transduction and proliferation in human melanocytes. J. Biol. Chem. 266 18352-7 PubMed GONUTS page

[PMID:10770212-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 Maggi, M et al. (2000) Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons. J. Clin. Endocrinol. Metab. 85 1658-65 PubMed GONUTS page

[PMID:2649896-10] 10.0 ^10.1 ^10.2 ^10.3 Inoue, A et al. (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. U.S.A. 86 2863-7 PubMed GONUTS page

[PMID:11410113-11] Hillier, C et al. (2001) Effect of adrenomedullin on the production of endothelin-1 and on its vasoconstrictor action in resistance arteries: evidence for a receptor-specific functional interaction in patients with heart failure. Clin. Sci. 101 45-51 PubMed GONUTS page

[PMID:19767294-12] 12.0 ^12.1 ^12.2 Helbing, T et al. (2010) Krüppel-like factor 15 regulates BMPER in endothelial cells. Cardiovasc. Res. 85 551-9 PubMed GONUTS page

[PMID:9696419-13] 13.0 ^13.1 Elferink, JG & De Koster, BM (1998) The involvement of protein kinase G in stimulation of neutrophil migration by endothelins. Eur. J. Pharmacol. 350 285-91 PubMed GONUTS page

[PMID:9422810-14] Maguire, JJ et al. (1997) Endothelin converting enzyme (ECE) activity in human vascular smooth muscle. Br. J. Pharmacol. 122 1647-54 PubMed GONUTS page

[PMID:8982507-15] Bogoni, G et al. (1996) Characterization of endothelin receptors in the human umbilical artery and vein. Br. J. Pharmacol. 119 1600-4 PubMed GONUTS page

[PMID:17078114-16] 16.0 ^16.1 ^16.2 Grant, K et al. (2007) Mechanisms of endothelin 1-stimulated proliferation in colorectal cancer cell lines. Br J Surg 94 106-12 PubMed GONUTS page

[PMID:12379507-17] 17.0 ^17.1 Evans, JJ et al. (2002) Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells. J. Endocrinol. 175 225-32 PubMed GONUTS page

[PMID:15691296-18] Dimoulios, P et al. (2005) Ursodeoxycholic acid reduces increased circulating endothelin 2 in primary biliary cirrhosis. Aliment. Pharmacol. Ther. 21 227-34 PubMed GONUTS page

[PMID:8999856-19] 19.0 ^19.1 Noiri, E et al. (1997) Permissive role of nitric oxide in endothelin-induced migration of endothelial cells. J. Biol. Chem. 272 1747-52 PubMed GONUTS page

[PMID:1725334-20] McKay, KO et al. (1991) Functional and autoradiographic studies of endothelin-1 and endothelin-2 in human bronchi, pulmonary arteries, and airway parasympathetic ganglia. J. Cardiovasc. Pharmacol. 17 Suppl 7 S206-9 PubMed GONUTS page

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