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HUMAN:DSCAM
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | DSCAM | |
| Protein Name(s) | Down syndrome cell adhesion molecule
CHD2 | |
| External Links | ||
| UniProt | O60469 | |
| EMBL | AF023450 AF023449 AF217525 AL163283 AL163282 AL163281 | |
| CCDS | CCDS42929.1 | |
| RefSeq | NP_001258463.1 NP_001380.2 | |
| UniGene | Hs.397800 | |
| ProteinModelPortal | O60469 | |
| SMR | O60469 | |
| BioGrid | 108160 | |
| STRING | 9606.ENSP00000383303 | |
| PhosphoSite | O60469 | |
| PaxDb | O60469 | |
| PRIDE | O60469 | |
| Ensembl | ENST00000400454 | |
| GeneID | 1826 | |
| KEGG | hsa:1826 | |
| UCSC | uc002yyq.1 | |
| CTD | 1826 | |
| GeneCards | GC21M041382 | |
| HGNC | HGNC:3039 | |
| HPA | HPA019324 | |
| MIM | 602523 | |
| neXtProt | NX_O60469 | |
| PharmGKB | PA27491 | |
| eggNOG | NOG12793 | |
| GeneTree | ENSGT00770000120473 | |
| HOVERGEN | HBG051409 | |
| InParanoid | O60469 | |
| KO | K06767 | |
| OMA | WTLDEDP | |
| OrthoDB | EOG7R830M | |
| PhylomeDB | O60469 | |
| TreeFam | TF316846 | |
| Reactome | REACT_25299 | |
| ChiTaRS | DSCAM | |
| GenomeRNAi | 1826 | |
| NextBio | 7449 | |
| PRO | PR:O60469 | |
| Proteomes | UP000005640 | |
| Bgee | O60469 | |
| CleanEx | HS_DSCAM | |
| ExpressionAtlas | O60469 | |
| Genevestigator | O60469 | |
| GO | GO:0030424 GO:0005576 GO:0030426 GO:0005887 GO:0016020 GO:0005886 GO:0007155 GO:0048813 GO:0070593 GO:0007626 GO:0007162 GO:0007399 GO:0048842 GO:0042327 GO:0060060 | |
| Gene3D | 2.60.40.10 | |
| InterPro | IPR003961 IPR007110 IPR013783 IPR013098 IPR003599 IPR003598 | |
| Pfam | PF00041 PF07679 | |
| SMART | SM00060 SM00409 SM00408 | |
| SUPFAM | SSF49265 | |
| PROSITE | PS50853 PS50835 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0007411 |
axon guidance |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:1990890 |
netrin receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060219 |
camera-type eye photoreceptor cell differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010842 |
retina layer formation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007416 |
synapse assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007156 |
homophilic cell adhesion via plasma membrane adhesion molecules |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070593 |
dendrite self-avoidance |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048842 |
positive regulation of axon extension involved in axon guidance |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042327 |
positive regulation of phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030426 |
growth cone |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030424 |
axon |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007162 |
negative regulation of cell adhesion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0098632 |
cell-cell adhesion mediator activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0010473 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070593 |
dendrite self-avoidance |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0010473 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030424 |
axon |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104750 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007411 |
axon guidance |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0010473 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007156 |
homophilic cell adhesion via plasma membrane adhesion molecules |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000635 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000635 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:1990890 |
netrin receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERC8 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:1990782 |
protein tyrosine kinase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERC8 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070593 |
dendrite self-avoidance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERC8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060060 |
post-embryonic retina morphogenesis in camera-type eye |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERC8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048842 |
positive regulation of axon extension involved in axon guidance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERC8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048813 |
dendrite morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERC8 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERC8 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0038007 |
netrin-activated signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERC8 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030426 |
growth cone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERC8 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERC8 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030424 |
axon |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERC8 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007626 |
locomotory behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERC8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007411 |
axon guidance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERC8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007162 |
negative regulation of cell adhesion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERC8 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9ERC8 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
PMID:9426258[5] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030424 |
axon |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030426 |
growth cone |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Purohit, AA et al. (2012) Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. J. Biol. Chem. 287 27126-38 PubMed GONUTS page
- ↑ Ly, A et al. (2008) DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Cell 133 1241-54 PubMed GONUTS page
- ↑ Liu, G et al. (2009) DSCAM functions as a netrin receptor in commissural axon pathfinding. Proc. Natl. Acad. Sci. U.S.A. 106 2951-6 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Yamakawa, K et al. (1998) DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system. Hum. Mol. Genet. 7 227-37 PubMed GONUTS page
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