GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:DPTOR

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DEPTOR (synonyms: DEPDC6)
Protein Name(s) DEP domain-containing mTOR-interacting protein

DEP domain-containing protein 6

External Links
UniProt Q8TB45
EMBL AL136678
AK022490
AK023916
AK297822
AK315175
AC091563
AP005717
CH471060
BC012040
BC024746
CCDS CCDS6331.1
CCDS64960.1
RefSeq NP_001269941.1
NP_073620.2
UniGene Hs.112981
ProteinModelPortal Q8TB45
SMR Q8TB45
BioGrid 122304
IntAct Q8TB45
MINT MINT-4712528
PhosphoSite Q8TB45
DMDM 251757257
MaxQB Q8TB45
PaxDb Q8TB45
PRIDE Q8TB45
DNASU 64798
Ensembl ENST00000286234
ENST00000523492
GeneID 64798
KEGG hsa:64798
UCSC uc003yow.4
CTD 64798
GeneCards GC08P120886
H-InvDB HIX0017353
HIX0025586
HGNC HGNC:22953
HPA CAB020841
HPA023938
HPA023945
HPA024011
MIM 612974
neXtProt NX_Q8TB45
PharmGKB PA134897957
eggNOG NOG125414
GeneTree ENSGT00520000055667
HOVERGEN HBG056008
InParanoid Q8TB45
OMA RIYEKLM
PhylomeDB Q8TB45
ChiTaRS DEPTOR
GeneWiki DEPTOR
GenomeRNAi 64798
NextBio 35473550
PRO PR:Q8TB45
Proteomes UP000005640
Bgee Q8TB45
CleanEx HS_DEPDC6
Genevestigator Q8TB45
GO GO:0005622
GO:0035556
GO:0045792
GO:0006469
GO:0032007
GO:2001236
Gene3D 1.10.10.10
2.30.42.10
InterPro IPR000591
IPR001478
IPR011991
Pfam PF00610
SMART SM00049
SM00228
SUPFAM SSF50156
PROSITE PS50186
PS50106

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005622

intracellular

GO_REF:0000054

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:2001236

regulation of extrinsic apoptotic signaling pathway

PMID:19446321[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045792

negative regulation of cell size

PMID:19446321[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032007

negative regulation of TOR signaling

PMID:19446321[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006469

negative regulation of protein kinase activity

PMID:19446321[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006469

negative regulation of protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037589

P

Seeded From UniProt

complete

involved_in

GO:0032007

negative regulation of TOR signaling

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037335
InterPro:IPR037336
InterPro:IPR037589

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000591

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Peterson, TR et al. (2009) DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137 873-86 PubMed GONUTS page