HUMAN:DOPO

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DBH
Protein Name(s)	Dopamine beta-hydroxylase Dopamine beta-monooxygenase Soluble dopamine beta-hydroxylase
External Links
UniProt	P09172
EMBL	AL365494 Y00096 BC017174 X13255 X13256
CCDS	CCDS6977.2
PIR	S03020
RefSeq	NP_000778.3
UniGene	Hs.591890
ProteinModelPortal	P09172
SMR	P09172
BioGrid	107989
IntAct	P09172
MINT	MINT-2843963
STRING	9606.ENSP00000376776
BindingDB	P09172
ChEMBL	CHEMBL3102
DrugBank	DB00822 DB00988 DB00550 DB00126
GuidetoPHARMACOLOGY	2486
PhosphoSite	P09172
DMDM	158517849
PaxDb	P09172
PRIDE	P09172
DNASU	1621
Ensembl	ENST00000393056
GeneID	1621
KEGG	hsa:1621
UCSC	uc004cel.3
CTD	1621
GeneCards	GC09P136501
GeneReviews	DBH
H-InvDB	HIX0008510
HGNC	HGNC:2689
HPA	HPA005960
MIM	223360 609312
neXtProt	NX_P09172
Orphanet	230
PharmGKB	PA136
eggNOG	NOG286384
GeneTree	ENSGT00530000063085
HOGENOM	HOG000063669
HOVERGEN	HBG005519
InParanoid	P09172
KO	K00503
OMA	SYFGDAW
OrthoDB	EOG78WKR4
PhylomeDB	P09172
TreeFam	TF320698
BioCyc	MetaCyc:MONOMER66-381
Reactome	REACT_15551
SignaLink	P09172
UniPathway	UPA00748
GeneWiki	Dopamine_beta_hydroxylase
GenomeRNAi	1621
NextBio	6654
PRO	PR:P09172
Proteomes	UP000005640
Bgee	P09172
CleanEx	HS_DBH
ExpressionAtlas	P09172
Genevestigator	P09172
GO	GO:0034466 GO:0042584 GO:0005737 GO:0005576 GO:0016021 GO:0016020 GO:0034774 GO:0030658 GO:0003824 GO:0005507 GO:0004500 GO:0031418 GO:0048149 GO:0001974 GO:0042423 GO:0034641 GO:0001816 GO:0042420 GO:0042596 GO:0042593 GO:0042309 GO:0002443 GO:0050900 GO:0007626 GO:0042711 GO:0007613 GO:0042421 GO:0045907 GO:0042127 GO:2001236 GO:0001975 GO:0048265 GO:0044281 GO:0007268 GO:0008542
Gene3D	2.60.120.230 2.60.120.310
InterPro	IPR014784 IPR020611 IPR014783 IPR000323 IPR000945 IPR005018 IPR008977 IPR028460
PANTHER	PTHR10157 PTHR10157:SF4
Pfam	PF01082 PF03351
PRINTS	PR00767
SMART	SM00664
SUPFAM	SSF49742
PROSITE	PS00084 PS00085 PS50836

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:9139828^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64237	P	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:27152332^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004500	dopamine beta-monooxygenase activity	PMID:3443096^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042420	dopamine catabolic process	PMID:3443096^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004500	dopamine beta-monooxygenase activity	PMID:7961964^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042420	dopamine catabolic process	PMID:7961964^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:7961964^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:7961964^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0034774	secretory granule lumen	PMID:7961964^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	PMID:7961964^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042421	norepinephrine biosynthetic process	PMID:27148966^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:14718574^[6]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042421	norepinephrine biosynthetic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94864 PANTHER:PTN000806665 RGD:2489 UniProtKB:P09172	P	Seeded From UniProt	complete
involved_in	GO:0042420	dopamine catabolic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94864 PANTHER:PTN000806665 UniProtKB:P09172 UniProtKB:P15101	P	Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94864 PANTHER:PTN000806665 UniProtKB:P09172	C	Seeded From UniProt	complete
enables	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010329 PANTHER:PTN001605435	F	Seeded From UniProt	complete
involved_in	GO:0006589	octopamine biosynthetic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000806665 WB:WBGene00006541	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001605435 RGD:2489	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000806665 UniProtKB:P09172 UniProtKB:P15101	C	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001605435 RGD:2489 UniProtKB:P09172 UniProtKB:P15101	F	Seeded From UniProt	complete
enables	GO:0004500	dopamine beta-monooxygenase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000806665 RGD:2489 UniProtKB:P09172 UniProtKB:P15101	F	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:2001236	regulation of extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0048265	response to pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0048149	behavioral response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0042711	maternal behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0042596	fear response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0042421	norepinephrine biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0042420	dopamine catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0042309	homoiothermy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
part_of	GO:0034774	secretory granule lumen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	C	Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	C	Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0008306	associative learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0002443	leukocyte mediated immunity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
involved_in	GO:0001816	cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64237 ensembl:ENSMUSP00000000910	P	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008977	F	Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000323 InterPro:IPR036939	F	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000323 InterPro:IPR036939	F	Seeded From UniProt	complete
enables	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000323 InterPro:IPR014783 InterPro:IPR014784 InterPro:IPR020611 InterPro:IPR036939	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000323 InterPro:IPR014783 InterPro:IPR014784 InterPro:IPR020611 InterPro:IPR028460 InterPro:IPR036939	P	Seeded From UniProt	complete
enables	GO:0004500	dopamine beta-monooxygenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.17.1	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:3443096^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:2880016^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:3443096^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	PMID:3443096^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042423	catecholamine biosynthetic process	Reactome:R-HSA-209905	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0034774	secretory granule lumen	Reactome:R-HSA-209891	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
enables	GO:0031418	L-ascorbic acid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0847	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0503	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0042423	catecholamine biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0127	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0042584	chromaffin granule membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0062	C	Seeded From UniProt	complete
part_of	GO:0034466	chromaffin granule lumen	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0349	C	Seeded From UniProt	complete
part_of	GO:0030658	transport vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0245	C	Seeded From UniProt	complete
involved_in	GO:0042421	norepinephrine biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00748	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Thomas, SA & Palmiter, RD (1997) Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline. Nature 387 94-7 PubMed GONUTS page
↑ Vendelboe, TV et al. (2016) The crystal structure of human dopamine β-hydroxylase at 2.9 Å resolution. Sci Adv 2 e1500980 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Lamouroux, A et al. (1987) The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme. EMBO J. 6 3931-7 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Kobayashi, K et al. (1994) Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice. J. Biol. Chem. 269 29725-31 PubMed GONUTS page
↑ Cubells, JF et al. (2016) Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice. PLoS ONE 11 e0154864 PubMed GONUTS page
↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Man in 't Veld, AJ et al. (1987) Congenital dopamine-beta-hydroxylase deficiency. A novel orthostatic syndrome. Lancet 1 183-8 PubMed GONUTS page

[PMID:9139828-1] Thomas, SA & Palmiter, RD (1997) Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline. Nature 387 94-7 PubMed GONUTS page

[PMID:27152332-2] Vendelboe, TV et al. (2016) The crystal structure of human dopamine β-hydroxylase at 2.9 Å resolution. Sci Adv 2 e1500980 PubMed GONUTS page

[PMID:3443096-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Lamouroux, A et al. (1987) The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme. EMBO J. 6 3931-7 PubMed GONUTS page

[PMID:7961964-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Kobayashi, K et al. (1994) Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice. J. Biol. Chem. 269 29725-31 PubMed GONUTS page

[PMID:27148966-5] Cubells, JF et al. (2016) Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice. PLoS ONE 11 e0154864 PubMed GONUTS page

[PMID:14718574-6] Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2880016-8] Man in 't Veld, AJ et al. (1987) Congenital dopamine-beta-hydroxylase deficiency. A novel orthostatic syndrome. Lancet 1 183-8 PubMed GONUTS page

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HUMAN:DOPO

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