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HUMAN:DOPD
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | DDT | |
| Protein Name(s) | D-dopachrome decarboxylase
D-dopachrome tautomerase Phenylpyruvate tautomerase II | |
| External Links | ||
| UniProt | P30046 | |
| EMBL | U49785 U84143 Y11151 AF012434 AF012432 AF012433 AF058293 CR456431 AK298326 AP000351 Z84718 CH471095 BC005971 BC015508 | |
| CCDS | CCDS13820.1 | |
| PIR | G02438 JE0162 | |
| RefSeq | NP_001077861.1 NP_001346.1 XP_005261356.1 | |
| UniGene | Hs.656723 Hs.744172 | |
| PDB | 1DPT 3KAN 4Q3F | |
| PDBsum | 1DPT 3KAN 4Q3F | |
| ProteinModelPortal | P30046 | |
| SMR | P30046 | |
| BioGrid | 108018 | |
| IntAct | P30046 | |
| MINT | MINT-5000166 | |
| STRING | 9606.ENSP00000215773 | |
| PhosphoSite | P30046 | |
| DMDM | 2828192 | |
| SWISS-2DPAGE | P30046 | |
| UCD-2DPAGE | P30046 | |
| PaxDb | P30046 | |
| PeptideAtlas | P30046 | |
| PRIDE | P30046 | |
| DNASU | 1652 | |
| Ensembl | ENST00000350608 ENST00000398344 ENST00000430101 ENST00000615721 | |
| GeneID | 100037417 1652 | |
| KEGG | hsa:100037417 hsa:1652 | |
| UCSC | uc002zyz.4 | |
| CTD | 1652 | |
| GeneCards | GC22M024313 | |
| HGNC | HGNC:2732 | |
| HPA | HPA049871 | |
| MIM | 602750 | |
| neXtProt | NX_P30046 | |
| PharmGKB | PA27197 | |
| eggNOG | NOG284179 | |
| GeneTree | ENSGT00730000111233 | |
| HOGENOM | HOG000112325 | |
| HOVERGEN | HBG003240 | |
| InParanoid | P30046 | |
| KO | K10028 | |
| OrthoDB | EOG7GXPDN | |
| PhylomeDB | P30046 | |
| TreeFam | TF313853 | |
| BRENDA | 4.1.1.84 | |
| ChiTaRS | DDT | |
| EvolutionaryTrace | P30046 | |
| GeneWiki | DDT_(gene) | |
| GenomeRNAi | 1652 | |
| NextBio | 35479618 | |
| PRO | PR:P30046 | |
| Proteomes | UP000005640 UP000005640 | |
| Bgee | P30046 | |
| CleanEx | HS_DDT | |
| ExpressionAtlas | P30046 | |
| Genevestigator | P30046 | |
| GO | GO:0005737 GO:0070062 GO:0033981 GO:0004167 GO:0042438 | |
| InterPro | IPR001398 IPR019829 IPR014347 | |
| PANTHER | PTHR11954 | |
| Pfam | PF01187 | |
| ProDom | PD004816 | |
| SUPFAM | SSF55331 | |
| PROSITE | PS01158 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0032760 |
positive regulation of tumor necrosis factor production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010760 |
negative regulation of macrophage chemotaxis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
part_of:(GO:1990869) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
occurs_in:(CL:0000235) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005126 |
cytokine receptor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050178 |
phenylpyruvate tautomerase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(CHEBI:15999) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000305 |
curator inference used in manual assertion |
GO:0032760 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001969) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0033981 |
D-dopachrome decarboxylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004167 |
dopachrome isomerase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016829 |
lyase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042438 |
melanin biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Merk, M et al. (2011) The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF). Proc. Natl. Acad. Sci. U.S.A. 108 E577-85 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Nishihira, J et al. (1998) Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation. Biochem. Biophys. Res. Commun. 243 538-44 PubMed GONUTS page
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