HUMAN:DLG4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DLG4 (synonyms: PSD95)
Protein Name(s)	Disks large homolog 4 Postsynaptic density protein 95 PSD-95 Synapse-associated protein 90 SAP-90 SAP90
External Links
UniProt	P78352
EMBL	U83192 AF156495 AK293835 AC120057 CH471108 U68138
CCDS	CCDS45599.1 CCDS45600.1
PIR	T09599
RefSeq	NP_001122299.1 NP_001356.1 XP_005256549.1
UniGene	Hs.463928
PDB	1KEF 3I4W 3K82 3ZRT
PDBsum	1KEF 3I4W 3K82 3ZRT
ProteinModelPortal	P78352
SMR	P78352
BioGrid	108086
DIP	DIP-30919N
IntAct	P78352
MINT	MINT-199061
STRING	9606.ENSP00000293813
BindingDB	P78352
ChEMBL	CHEMBL5666
DrugBank	DB00536
PhosphoSite	P78352
DMDM	71658825
MaxQB	P78352
PaxDb	P78352
PRIDE	P78352
Ensembl	ENST00000302955 ENST00000399506 ENST00000399510
GeneID	1742
KEGG	hsa:1742
UCSC	uc002get.4 uc010cly.3 uc010vtn.2
CTD	1742
GeneCards	GC17M007094
HGNC	HGNC:2903
HPA	CAB001999 CAB002000 HPA010122
MIM	602887
neXtProt	NX_P78352
PharmGKB	PA27359
eggNOG	COG0194
GeneTree	ENSGT00760000118866
HOGENOM	HOG000232102
HOVERGEN	HBG107814
InParanoid	P78352
KO	K11828
OMA	CLEDVMH
PhylomeDB	P78352
TreeFam	TF323171
Reactome	REACT_18307 REACT_20546 REACT_20594 REACT_20642 REACT_21346 REACT_22329
SignaLink	P78352
ChiTaRS	DLG4
EvolutionaryTrace	P78352
GeneWiki	DLG4
GenomeRNAi	1742
NextBio	7067
PRO	PR:P78352
Proteomes	UP000005640
Bgee	P78352
CleanEx	HS_DLG4
ExpressionAtlas	P78352
Genevestigator	P78352
GO	GO:0032281 GO:0030054 GO:0044300 GO:0030863 GO:0005737 GO:0032839 GO:0043197 GO:0030666 GO:0005783 GO:0060076 GO:0031234 GO:0044224 GO:0044306 GO:0044309 GO:0097481 GO:0005886 GO:0014069 GO:0045211 GO:0045202 GO:0008021 GO:0033130 GO:0031697 GO:0031748 GO:0035255 GO:0031812 GO:0030165 GO:0008022 GO:0032403 GO:0019903 GO:0097110 GO:0097113 GO:0007411 GO:0060997 GO:0045184 GO:0007612 GO:0035641 GO:0002091 GO:0007399 GO:0050885 GO:0007204 GO:2000463 GO:0050806 GO:0006461 GO:0035418 GO:0097120 GO:2000821 GO:0048169 GO:2000310 GO:0007165 GO:0035176 GO:0007268 GO:0016188 GO:0071625
Gene3D	2.30.42.10 3.40.50.300
InterPro	IPR016313 IPR008145 IPR008144 IPR020590 IPR019590 IPR027417 IPR001478 IPR019583 IPR001452
PANTHER	PTHR23119
Pfam	PF00625 PF10608 PF00595 PF10600 PF00018
PIRSF	PIRSF001741
SMART	SM00072 SM00228 SM00326
SUPFAM	SSF50044 SSF50156 SSF52540
PROSITE	PS00856 PS50052 PS50106 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0097060	synaptic membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C	part_of:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:17526495^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6AYP5	C		Seeded From UniProt	complete
involved_in	GO:0150012	positive regulation of neuron projection arborization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
enables	GO:0097109	neuroligin family protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	F		Seeded From UniProt	complete
colocalizes_with	GO:0008076	voltage-gated potassium channel complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C	part_of:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0035865	cellular response to potassium ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	P		Seeded From UniProt	complete
involved_in	GO:0097120	receptor localization to synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	F		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	P		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	C		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
involved_in	GO:0050806	positive regulation of synaptic transmission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	P		Seeded From UniProt	complete
involved_in	GO:0048169	regulation of long-term neuronal synaptic plasticity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:15496675^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	PMID:15496675^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0044309	neuron spine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
part_of	GO:0044306	neuron projection terminus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
part_of	GO:0044224	juxtaparanode region of axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	C		Seeded From UniProt	complete
part_of	GO:0044224	juxtaparanode region of axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
involved_in	GO:0035418	protein localization to synapse	PMID:15496675^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	F		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	F		Seeded From UniProt	complete
enables	GO:0033130	acetylcholine receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	F		Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	F		Seeded From UniProt	complete
part_of	GO:0032281	AMPA glutamate receptor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
enables	GO:0031812	P2Y1 nucleotide receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	F		Seeded From UniProt	complete
enables	GO:0031748	D1 dopamine receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	F		Seeded From UniProt	complete
enables	GO:0031697	beta-1 adrenergic receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	F		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	F		Seeded From UniProt	complete
involved_in	GO:0016188	synaptic vesicle maturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	C		Seeded From UniProt	complete
colocalizes_with	GO:0008328	ionotropic glutamate receptor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	PMID:15496675^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
involved_in	GO:0002091	negative regulation of receptor internalization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:12151521^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030863	cortical cytoskeleton	PMID:12151521^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31016	C		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:7477295^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22459	F		Seeded From UniProt	complete
involved_in	GO:0098970	postsynaptic neurotransmitter receptor diffusion trapping	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002508435 RGD:68424	P		Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1277959 PANTHER:PTN000563569	C		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001501163 UniProtKB:Q12959 UniProtKB:Q14160	P		Seeded From UniProt	complete
involved_in	GO:0097120	receptor localization to synapse	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001501163 RGD:68424	P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001501209 RGD:68424	P		Seeded From UniProt	complete
involved_in	GO:0043113	receptor clustering	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001501163 RGD:619895	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000563569 RGD:2505	C		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1277959 PANTHER:PTN001501163 RGD:2505 RGD:68423 RGD:68424	F		Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001624 FB:FBgn0029830 MGI:MGI:107231 PANTHER:PTN000563569	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107231 MGI:MGI:1277959 MGI:MGI:1344351 PANTHER:PTN001501163 UniProtKB:Q12959 UniProtKB:Q14160	C		Seeded From UniProt	complete
colocalizes_with	GO:0008328	ionotropic glutamate receptor complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1277959 PANTHER:PTN001501163	C		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001624 MGI:MGI:1344351 PANTHER:PTN000563569	P		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	PMID:21119615^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000821	regulation of grooming behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	P		Seeded From UniProt	complete
involved_in	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	F		Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
involved_in	GO:0071625	vocalization behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	P		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
involved_in	GO:0050885	neuromuscular process controlling balance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	P		Seeded From UniProt	complete
involved_in	GO:0048169	regulation of long-term neuronal synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0044309	neuron spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0044306	neuron projection terminus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0044300	cerebellar mossy fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0044224	juxtaparanode region of axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
involved_in	GO:0035865	cellular response to potassium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	P		Seeded From UniProt	complete
involved_in	GO:0035641	locomotory exploration behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	P		Seeded From UniProt	complete
involved_in	GO:0035418	protein localization to synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	P		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	F		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	P		Seeded From UniProt	complete
part_of	GO:0032281	AMPA glutamate receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
involved_in	GO:0016188	synaptic vesicle maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0008328	ionotropic glutamate receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62108 ensembl:ENSMUSP00000104229	C		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:17526495^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:P06241) causally_upstream_of:(GO:2000310)	Seeded From UniProt	complete
involved_in	GO:0007612	learning	PMID:9853749^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:9286702^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:9853749^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10364559^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	PMID:19914352^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	Reactome:R-HSA-438066	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	Reactome:R-HSA-416320	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8849906 Reactome:R-HSA-8849891 Reactome:R-HSA-8849878 Reactome:R-HSA-5682794 Reactome:R-HSA-5672965 Reactome:R-HSA-5671993 Reactome:R-HSA-451311 Reactome:R-HSA-451283 Reactome:R-HSA-432164 Reactome:R-HSA-416320	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-6797554	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Wu, HY et al. (2007) Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. J. Biol. Chem. 282 20075-87 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Romorini, S et al. (2004) A functional role of postsynaptic density-95-guanylate kinase-associated protein complex in regulating Shank assembly and stability to synapses. J. Neurosci. 24 9391-404 PubMed GONUTS page
↑ ^3.0 ^3.1 Chetkovich, DM et al. (2002) Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms. J. Neurosci. 22 6415-25 PubMed GONUTS page
↑ Kim, E et al. (1995) Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Nature 378 85-8 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Yang, J et al. (2011) DGKι regulates presynaptic release during mGluR-dependent LTD. EMBO J. 30 165-80 PubMed GONUTS page
↑ ^7.0 ^7.1 Migaud, M et al. (1998) Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein. Nature 396 433-9 PubMed GONUTS page
↑ Stathakis, DG et al. (1997) Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues. Genomics 44 71-82 PubMed GONUTS page
↑ Sattler, R et al. (1999) Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science 284 1845-8 PubMed GONUTS page
↑ Levinson, JN et al. (2010) Postsynaptic scaffolding molecules modulate the localization of neuroligins. Neuroscience 165 782-93 PubMed GONUTS page

[PMID:17526495-1] 1.0 ^1.1 Wu, HY et al. (2007) Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. J. Biol. Chem. 282 20075-87 PubMed GONUTS page

[PMID:15496675-2] 2.0 ^2.1 ^2.2 ^2.3 Romorini, S et al. (2004) A functional role of postsynaptic density-95-guanylate kinase-associated protein complex in regulating Shank assembly and stability to synapses. J. Neurosci. 24 9391-404 PubMed GONUTS page

[PMID:12151521-3] 3.0 ^3.1 Chetkovich, DM et al. (2002) Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms. J. Neurosci. 22 6415-25 PubMed GONUTS page

[PMID:7477295-4] Kim, E et al. (1995) Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Nature 378 85-8 PubMed GONUTS page

[PMID:21873635-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21119615-6] Yang, J et al. (2011) DGKι regulates presynaptic release during mGluR-dependent LTD. EMBO J. 30 165-80 PubMed GONUTS page

[PMID:9853749-7] 7.0 ^7.1 Migaud, M et al. (1998) Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein. Nature 396 433-9 PubMed GONUTS page

[PMID:9286702-8] Stathakis, DG et al. (1997) Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues. Genomics 44 71-82 PubMed GONUTS page

[PMID:10364559-9] Sattler, R et al. (1999) Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science 284 1845-8 PubMed GONUTS page

[PMID:19914352-10] Levinson, JN et al. (2010) Postsynaptic scaffolding molecules modulate the localization of neuroligins. Neuroscience 165 782-93 PubMed GONUTS page

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